Results 181 to 190 of about 4,677,373 (388)

Genetic vectors as a tool in association studies: definitions and application for study of rheumatoid arthritis. [PDF]

Int J Genomics, 2015
Sandalov I, Padyukov L.
europepmc   +1 more source

Biochemical genetics of blackfly isozymes : II. Genetic variability and differentiation among natural populations of Simulium ochraceum, the vector of onchocerciasis, in Guatemala

, 1987
Takeshi Agatsuma, Kiichi UEMOTO, A. J. Onofre OCHOA   +2 more
openalex   +2 more sources

Novel Design Architecture for Genetic Stability of Recombinant Poliovirus: the Manipulation of G/C Contents and Their Distribution Patterns Increases the Genetic Stability of Inserts in a Poliovirus-Based RPS-Vax Vector System [PDF]

, 2002
Sang‐Gu Lee, Dae-You Kim, Byung‐Hwa Hyun, Yong‐Soo Bae   +3 more
openalex   +1 more source

An efficient strategy for producing RNA‐free Nucleocapsid protein of SARS‐CoV‐2 for biochemical and structural investigations

FEBS Open Bio, EarlyView.
Cleavable N‐terminal Thioredoxin fusion enabled soluble expression and purification of otherwise insoluble SARS‐CoV‐2 Nucleocapsid (N) protein. A four‐step purification strategy yielded highly homogeneous, RNA‐free N protein. Binding assays showed high RNA affinity (Kd ~ 28 nm). The study will facilitate high‐resolution structural studies of N protein,
Shweta Singh, Gagan D. Gupta
wiley   +1 more source

Regulation of transgene expression in genetic immunization

Brazilian Journal of Medical and Biological Research, 1999
The use of mammalian gene expression vectors has become increasingly important for genetic immunization and gene therapy as well as basic research. Essential for the success of these vectors in genetic immunization is the proper choice of a promoter ...
Harms J.S., Oliveira S.C., Splitter G.A.
doaj  

Co‐overexpression of the caloric restriction‐induced mitochondrial factors PGC‐1α and MIPEP upregulates Phospho1 expression in adipocytes

FEBS Open Bio, EarlyView.
Caloric restriction that extends lifespan induces the expression of PGC‐1α and MIPEP in white adipose tissue. In this study, co‐overexpression of Pgc‐1α and Mipep upregulated the gene expression of PHOSPHO1. These findings provide new insights into mitochondria‐related mechanisms underlying the effects of caloric restriction in adipocytes.
Mamiko Ishimatsu, Kanari Taki, Asuka Hayami, Komachi Kato, Yuka Nozaki, Yuhei Mizunoe, Takumi Narita, Ryoichi Mori, Yoshikazu Higami, Masaki Kobayashi   +9 more
wiley   +1 more source

Genetic stability of gene targeted immunoglobulin loci. I. Heavy chain isotype exchange induced by a universal gene replacement vector

, 1996
Christian Kardinal, Michael Selmayr, Ralph Mocikat   +2 more
openalex   +2 more sources

Vector for Positive Selection of In-Frame Genetic Sequences [PDF]

BioTechniques, 1997
Hawke, Noel A., Strong, Scott J., Haire, Robert N., Litman, Gary W.   +3 more
openaire   +4 more sources

The E3 ubiquitin ligase, RNF219, suppresses CNOT6L expression to exhibit antiproliferative activity

FEBS Open Bio, EarlyView.
We identified RNF219 as a CCR4‐NOT complex‐interacting E3 ubiquitin ligase that targets the CCR4‐NOT subunit CNOT6L for ubiquitination. RNF219 directly binds to the DUF3819 domain of CNOT1 through its putative α‐helix spanning amino acids 521–542. Our findings also suggest that antiproliferative activity of RNF219 is at least partially mediated by ...
Shou Soeda, Melissa Montrose, Akinori Takahashi, Risa Ishida, Sandrine Burriel, Nao Ohmine, Tohru Natsume, Shungo Adachi, Minsoo Kim, Tadashi Yamamoto   +9 more
wiley   +1 more source

Intracerebral Transplantation and Successful Integration of Astrocytes following Genetic Modification with a High-Capacity Adenoviral Vector [PDF]

, 2002
Stefan Arnhold, Florian Kreppel, S. Kandirali, Doris Lenartz, Franz‐Josef Klinz, Volker Sturm, Stefan Kochanek, Christian Andressen, Klaus Addicks   +8 more
openalex   +1 more source