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Genetic modification of lymphocytes by retrovirus-based vectors
Current Opinion in Immunology, 2012The genetic modification of lymphocytes is an important topic in the emerging field of gene therapy. Many clinical trials targeting immunodeficiency syndromes or cancer have shown therapeutic benefit; further applications address inflammatory and infectious disorders.
Christopher Baum +2 more
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The biogeography and population genetics of neotropical vector species
Heredity, 2007Phylogenetic and population genetic data support the Pliocene or Pleistocene divergences of the co-distributed hematophagous insect vectors, the sand fly Lutzomyia longipalpis s.l., the mosquitoes Anopheles darlingi and A. albitarsis s.l., and the triatomines Rhodnius prolixus and R. robustus.
Jan E. Conn, Jan E. Conn, L Mirabello
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Plasmid RP4 as a vector replicon in genetic engineering
Nature, 1975THERE is now considerable interest in the construction of plasmids containing DNA fragments from a variety of bacterial genera, for purposes of studying the expression of the genetic potentialities of the incorporated bacterial DNA in different bacterial hosts.
A. E. Jacob, N. J. Grinter
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Entrapment Vectors: A New Tool for Mammalian Genetics
Nature Biotechnology, 1990The use of mouse embryonic stem (ES) cells has facilitated the creation of mouse strains carrying desired genetic alterations. Recently, "entrapment" vectors have been developed to identify and mutate genes active during embryogenesis. These vectors in combination with ES cells may provide an efficient screening strategy to find genes that control ...
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Vector quantization based on genetic simulated annealing
Signal Processing, 2001zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Hsueh-Ming Hang +4 more
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PiggyBac transposon vectors: the tools of the human gene encoding.
Translational Lung Cancer Research, 2016A transposon is a DNA segment, which is able to change its relative position within the entire genome of a cell. The piggyBac (PB) transposon is a movable genetic element that efficiently transposes between vectors and chromosomes through a "cut-and ...
Shuang Zhao +7 more
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FPGA implementation of genetic vector quantizers
Neurocomputing, 2010This paper presents a novel hardware architecture for genetic vector quantizer (VQ) design. It is based on steady-state genetic algorithm (GA) and adopts shift registers for accelerating mutation and crossover operations while reducing area cost. It also uses a pipeline for fitness evaluation.
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Synthetic Vectors for Genetic Drug Delivery
2006Gene therapy is a new approach in the treatment of numerous diseases caused by damage to or lack of certain genes. Its application seems to be very effective, especially in the case of cancer diseases, where genetic drugs can be designed to selectively eliminate damaged cells. Due to the chemical properties of nucleic acids, their introduction into the
Katarzyna Stebelska +3 more
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Genetic Engineering with Plant Viruses, and Their Potential as Vectors
1983Publisher Summary The chapter discusses the potential of plant viruses as vectors for introducing foreign genes into plants. Understanding how viruses function and interact with their hosts may lead to means of controlling some economically important plant diseases; inserting foreign genes may enable a means of improving economically important crops.
J.W. Davies, Roger Hull
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Engineering adeno-associated virus vectors for gene therapy
Nature reviews genetics, 2020Chengwen Li, R. Samulski
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