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Genetically Engineered Microorganisms and Their Impact on Human Health [PDF]
International Journal of Clinical PracticeThe emergence of antibiotic-resistant strains, the decreased effectiveness of conventional therapies, and the side effects have led researchers to seek a safer, more cost-effective, patient-friendly, and effective method that does not develop antibiotic ...
Marzie Mahdizade Ari +4 more
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CAR Macrophages for SARS-CoV-2 Immunotherapy
Frontiers in Immunology, 2021 Targeted therapeutics for the treatment of coronavirus disease 2019 (COVID-19), especially severe cases, are currently lacking. As macrophages have unique effector functions as a first-line defense against invading pathogens, we genetically armed human ...
Wenyan Fu +11 more
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Cells, 2022 Diabetic retinopathy (DR), the leading cause of blindness in working-age adults, is one of the most common complications of diabetes mellitus (DM) featured by metabolic disorders. With the global prevalence of diabetes, the incidence of DR is expected to
Qizhi Jian, Yingjie Wu, Fang Zhang
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TIGIT-Fc as a Potential Therapeutic Agent for Fetomaternal Tolerance
Frontiers in Immunology, 2021 The perfect synchronization of maternal immune-endocrine mechanisms and those of the fetus is necessary for a successful pregnancy. In this report, decidual immune cells at the maternal-fetal interface were detected that expressed TIGIT (T cell ...
Wenyan Fu +9 more
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miR-146a-5p Plays an Oncogenic Role in NSCLC via Suppression of TRAF6
Frontiers in Cell and Developmental Biology, 2020 Non-small cell lung cancer (NSCLC) is the most deadly cancer in the world due to its often delayed diagnosis. Identification of biomarkers with high sensitivity, specificity, and accessibility for early detection, such as circulating microRNAs, is ...
Xiangdong Liu +46 more
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Frontiers in Microbiology, 2020 Porcine hemagglutinating encephalomyelitis virus (PHEV) is a single-stranded RNA coronavirus that causes nervous dysfunction in the infected hosts and leads to widespread alterations in the host transcriptome by modulating specific microRNA (miRNA ...
Shiyu Hu +9 more
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Biocontainment of Genetically Engineered Algae
Frontiers in Plant Science, 2022 Algae (including eukaryotic microalgae and cyanobacteria) have been genetically engineered to convert light and carbon dioxide to many industrially and commercially relevant chemicals including biofuels, materials, and nutritional products. At industrial
Jacob Sebesta +3 more
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The Scientific World Journal, 2014 Background. Ex vivo culture of intact embryonic kidney has become a powerful system for studying renal development. However, few methods have been available for gene manipulation and have impeded the identification and investigation of genes in this ...
Tie-Lin Chen +7 more
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Encapsulated and ‘free’ pig islet xenotransplantation: recent experience and clinical progress* [PDF]
CellR4, 2019 Genetically-engineered pigs offer a possible alternative to deceased human donors as a source of isolated islets for transplantation into patients with life-threatening diabetes.
D. Cooper, R. Bottino
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Plants, 2021 Plant viruses cause yield losses to crops of agronomic and economic significance and are a challenge to the achievement of global food security. Although conventional plant breeding has played an important role in managing plant viral diseases, it will ...
Prakash M. Niraula, Vincent N. Fondong
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