Results 1 to 10 of about 143,498 (285)

CAR Macrophages for SARS-CoV-2 Immunotherapy

Frontiers in Immunology, 2021
Targeted therapeutics for the treatment of coronavirus disease 2019 (COVID-19), especially severe cases, are currently lacking. As macrophages have unique effector functions as a first-line defense against invading pathogens, we genetically armed human ...
Wenyan Fu, Wenyan Fu, Wenyan Fu, Changhai Lei, Changhai Lei, Zetong Ma, Kewen Qian, Tian Li, Tian Li, Jian Zhao, Shi Hu, Shi Hu   +11 more
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Metabolomics in Diabetic Retinopathy: From Potential Biomarkers to Molecular Basis of Oxidative Stress

Cells, 2022
Diabetic retinopathy (DR), the leading cause of blindness in working-age adults, is one of the most common complications of diabetes mellitus (DM) featured by metabolic disorders. With the global prevalence of diabetes, the incidence of DR is expected to
Qizhi Jian, Yingjie Wu, Fang Zhang
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TIGIT-Fc as a Potential Therapeutic Agent for Fetomaternal Tolerance

Frontiers in Immunology, 2021
The perfect synchronization of maternal immune-endocrine mechanisms and those of the fetus is necessary for a successful pregnancy. In this report, decidual immune cells at the maternal-fetal interface were detected that expressed TIGIT (T cell ...
Wenyan Fu, Renfei Cai, Zetong Ma, Zetong Ma, Tian Li, Changhai Lei, Changhai Lei, Jian Zhao, Shi Hu, Shi Hu   +9 more
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Photothermal Genetic Engineering [PDF]

ACS Nano, 2012
Optical methods for manipulation of cellular function have enabled deconstruction of genetic and neural circuits in vitro and in vivo. Plasmonic gold nanomaterials provide an alternative platform for external optical manipulation of genetic circuits.
Deisseroth, Karl, Anikeeva, Polina Olegovna   +1 more
openaire   +3 more sources

miR-146a-5p Plays an Oncogenic Role in NSCLC via Suppression of TRAF6

Frontiers in Cell and Developmental Biology, 2020
Non-small cell lung cancer (NSCLC) is the most deadly cancer in the world due to its often delayed diagnosis. Identification of biomarkers with high sensitivity, specificity, and accessibility for early detection, such as circulating microRNAs, is ...
Xiangdong Liu, Xiangdong Liu, Xiangdong Liu, Bo Liu, Bo Liu, Bo Liu, Ruihua Li, Fei Wang, Fei Wang, Fei Wang, Ning Wang, Ning Wang, Ning Wang, Maihe Zhang, Maihe Zhang, Maihe Zhang, Yang Bai, Yang Bai, Yang Bai, Jin Wu, Jin Wu, Jin Wu, Liping Liu, Liping Liu, Liping Liu, Dongyu Han, Dongyu Han, Dongyu Han, Zhiguang Li, Bin Feng, Guangbiao Zhou, Shujing Wang, Shujing Wang, Li Zeng, Li Zeng, Li Zeng, Jian Miao, Yiqun Yao, Bin Liang, Lin Huang, Lin Huang, Qi Wang, Yingjie Wu, Yingjie Wu, Yingjie Wu, Yingjie Wu, Yingjie Wu   +46 more
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Genetically engineering milk [PDF]

Journal of Dairy Research, 2016
It has been thirty years since the first genetically engineered animal with altered milk composition was reported. During the intervening years, the world population has increased from 5bn to 7bn people. An increasing demand for protein in the human diet has followed this population expansion, putting huge stress on the food supply chain.
Whitelaw, C Bruce A, Joshi, Akshay, Kumar, Satish, Lillico, Simon G, Proudfoot, Christopher   +4 more
openaire   +2 more sources

Loss of Adipose Growth Hormone Receptor in Mice Enhances Local Fatty Acid Trapping and Impairs Brown Adipose Tissue Thermogenesis

iScience, 2019
Summary: Growth hormone (GH) binds to its receptor (growth hormone receptor [GHR]) to exert its pleiotropic effects on growth and metabolism. Disrupted GH/GHR actions not only fail growth but also are involved in many metabolic disorders, as shown in ...
Liyuan Ran, Xiaoshuang Wang, Ai Mi, Yanshuang Liu, Jin Wu, Haoan Wang, Meihua Guo, Jie Sun, Bo Liu, Youwei Li, Dan Wang, Rujiao Jiang, Ning Wang, Wenting Gao, Li Zeng, Lin Huang, Xiaoli Chen, Derek LeRoith, Bin Liang, Xin Li, Yingjie Wu   +20 more
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Biocontainment of Genetically Engineered Algae

Frontiers in Plant Science, 2022
Algae (including eukaryotic microalgae and cyanobacteria) have been genetically engineered to convert light and carbon dioxide to many industrially and commercially relevant chemicals including biofuels, materials, and nutritional products. At industrial
Jacob Sebesta, Wei Xiong, Michael T. Guarnieri, Jianping Yu   +3 more
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A method for Absolute Protein Expression Quantity Measurement Employing Insulator RiboJ

Engineering, 2018
Measuring the absolute protein expression quantity for a specific promoter is necessary in the fields of both molecular biology and synthetic biology. The strength of a promoter is traditionally characterized by measuring the fluorescent intensity of the
Hongbin Yu, Zheng Wang, Hanyue Xu, Jiusi Guo, Qingge Ma, Xiangxu Mu, Yunzi Luo   +6 more
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MiR-10a-5p-Mediated Syndecan 1 Suppression Restricts Porcine Hemagglutinating Encephalomyelitis Virus Replication

Frontiers in Microbiology, 2020
Porcine hemagglutinating encephalomyelitis virus (PHEV) is a single-stranded RNA coronavirus that causes nervous dysfunction in the infected hosts and leads to widespread alterations in the host transcriptome by modulating specific microRNA (miRNA ...
Shiyu Hu, Zi Li, Yungang Lan, Jiyu Guan, Kui Zhao, Dianfeng Chu, Gencheng Fan, Yuguang Guo, Feng Gao, Wenqi He   +9 more
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