Results 11 to 20 of about 125,314 (293)
Genetic engineering in organoids [PDF]
Journal of Molecular Medicine, 2021 AbstractThree-dimensional organoids have been widely used for developmental and disease modeling. Organoids are derived from both adult and pluripotent stem cells. Various types are available for mimicking almost all major organs and tissues in the mouse and human.
Isaree Teriyapirom +2 more
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The arrival of genetic engineering [PDF]
IEEE Engineering in Medicine and Biology Magazine, 2009 The purpose of this article is to review the different strategies for the delivery of plasmid DNA (pDNA)-based gene therapy. Plasmids are extrachromosomal DNA capable of being transmitted from cell to cell. They are supercoiled, circular covalently closed (ccc) strands of DNA capable of replication independently of host DNA and ranging from 5 to 400 ...
Arulmuthu, E. +2 more
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Principles of Genetic Engineering [PDF]
Genes, 2020 Genetic engineering is the use of molecular biology technology to modify DNA sequence(s) in genomes, using a variety of approaches. For example, homologous recombination can be used to target specific sequences in mouse embryonic stem (ES) cell genomes or other cultured cells, but it is cumbersome, poorly efficient, and relies on drug positive/negative
Thomas M. Lanigan +2 more
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Genetically engineering milk [PDF]
Journal of Dairy Research, 2016 It has been thirty years since the first genetically engineered animal with altered milk composition was reported. During the intervening years, the world population has increased from 5bn to 7bn people. An increasing demand for protein in the human diet has followed this population expansion, putting huge stress on the food supply chain.
Whitelaw, C Bruce A +4 more
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Engineering Switches, Genetically [PDF]
Chemistry & Biology, 2004 Ostermeier, Guntas, and Mitchel describe a new approach to design enzymes that are allosterically regulated by an unrelated ligand . The resulting protein, constructed by nonhomologous recombination and genetic screens, displays switch-like behavior.
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Journal of Microbiology & Biology Education, 2018 Genetic analysis in model systems can provide a rich context for conceptual understanding of gene structure, regulation, and function. With an intent to create a rich learning experience in molecular genetics, we developed a semester-long course-based ...
Jay M. Bhatt, Anil Kumar Challa
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CAR exosomes derived from effector CAR-T cells have potent antitumour effects and low toxicity
Nature Communications, 2019 Genetically engineered T cells expressing a chimeric antigen receptor (CAR-T cells) are a promising new treatment for cancer, but are associated with unique toxicities. Here, the authors test CAR-T-cell-derived exosomes as a surrogate for CAR-T cells and
Wenyan Fu +14 more
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مجلة مركز بحوث التقنيات الاحيائية, 2014 Thediosgenin compound was separated, one of the secondary metabolic product in Trigonella foenum-graecum L. plants. Hairy roots cultures transformed by Agrobacterium rhizogenes R1601, and their spontaneously formed callus contained "diosgenin".
M. M. Al-Mahdawe +2 more
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Forecasting SARS-CoV-2 spike protein evolution from small data by deep learning and regression
Frontiers in Systems BiologyThe emergence of SARS-CoV-2 variants during the COVID-19 pandemic caused frequent global outbreaks that confounded public health efforts across many jurisdictions, highlighting the need for better understanding and prediction of viral evolution ...
Samuel King +39 more
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