Results 61 to 70 of about 125,314 (293)

K27-linked RORγt ubiquitination by Nedd4 potentiates Th17-mediated autoimmunity

Journal of Biomedical Science
Background The HECT E3 ubiquitin ligase Nedd4 has been shown to positively regulate T cell responses, but its role in T helper (Th) cell differentiation and autoimmunity is unknown.
Qiuming Zeng, Hui Guo, Na Tang, Pranav S. Renavikar, Nitin J. Karandikar, Amy E. Lovett-Racke, Michael K. Racke, Chengkai Yan, Rong Tang, Sushmita Sinha, Krishnendu Ghosh, Jeremy P. Ryal, Song Ouyang, Min Chen, Foued Amari, Coppola Vincenzo, R. Marshall Pope, Yalan Li, Huan Yang, Wallace Y. Langdon, Jian Zhang   +20 more
doaj   +1 more source

Current trends in single‐cell RNA sequencing applications in diabetes mellitus

FEBS Open Bio, EarlyView.
Single‐cell RNA sequencing is a powerful approach to decipher the cellular and molecular landscape at a single‐cell resolution. The rapid development of this technology has led to a wide range of applications, including the detection of cellular and molecular mechanisms and the identification and introduction of novel potential diagnostic and ...
Seyed Sajjad Zadian, Khodakaram Jahanbin, Shekoofeh Nikooei, Marzieh Rostaminejad, Arezoo Rahimi, Pedram Abdizadeh, Behnam Alipoor   +6 more
wiley   +1 more source

Insulin receptor isoform B is required for efficient proinsulin processing in pancreatic β cells

iScience
Summary: The insulin receptor (INSR, IR) has two isoforms, IRA and IRB, through alternative splicing. However, their distinct functions in vivo remain unclear. Here we generated β cell-specific IRB knockout (KO) mice (βIRBKO).
Mingchao Jiang, Ning Wang, Yuqin Zhang, Jinjin Zhang, Youwei Li, Xiu Yan, Honghao Zhang, Chengbin Li, Youfei Guan, Bin Liang, Weiping Zhang, Yingjie Wu   +11 more
doaj  

Microfluidic electro‐viscoelastic manipulation of extracellular vesicles

FEBS Open Bio, EarlyView.
The electro‐viscoelastic manipulation as a potential method for separation of particles based on size. The particles introduced as a sheath flow migrate to the channel center under the influence of simultaneously applied electric field and pressure driven flow.
Seyedamirhosein Abdorahimzadeh, Éva Bozó, Zikrullah Bölükkaya, Artem Zhyvolozhnyi, Anatoliy Samoylenko, Henrikki Liimatainen, Seppo J. Vainio, Caglar Elbuken   +7 more
wiley   +1 more source

Genetically engineered nanocarriers for drug delivery

International Journal of Nanomedicine, 2014
Pu Shi, Joshua A Gustafson, J Andrew MacKayDepartment of Pharmacology and Pharmaceutical Sciences, University of Southern California, Los Angeles, CA, USAAbstract: Cytotoxicity, low water solubility, rapid clearance from circulation, and off-target side ...
Shi P, Gustafson JA, MacKay JA
doaj  

Construction strategies of genetically engineered bacteria for environment bioremediation

浙江大学学报. 农业与生命科学版, 2002
Genetically engineered bacteria hold promising potential in the future applications of bioremediation. This paper presents several construction strategies of genetically engineered bacteria for the bioremediation purpose through analyzing the ...
LIU He, CHEN Ying-xu
doaj   +1 more source

Mitochondrial DNA disorders in neuromuscular diseases in diverse populations

Annals of Clinical and Translational Neurology, EarlyView.
Abstract Neuromuscular features are common in mitochondrial DNA (mtDNA) disorders. The genetic architecture of mtDNA disorders in diverse populations is poorly understood. We analysed mtDNA variants from whole‐exome sequencing data in neuromuscular patients from South Africa, Brazil, India, Turkey and Zambia. In 998 individuals, there were two definite
Fei Gao, Katherine R Schon, Jana Vandrovcova, Özlem Yayıcı Köken, Sharika Raga, Kireshnee Naidu, Maryke Schoonen, Nimita Rani, Pedro Tomaselli, Dipti Baskar, Musambo Kapapa, Ipek Polat, Lindsay A Wilson, Kumarasamy Thangaraj, Uluç Yiş, Bevinahalli N Nandeesh, David Bearden, Michelle Kvalsund, Franclo Henning, Seena Vengalil, Atchayaram Nalini, Claudia F. R. Sobreira, Wilson Marques, Haluk Topoloğlu, Michael G Hanna, Sireesha Yareeda, Venugopalan Y Vishnu, Francois H van der Westhuizen, Izelle Smuts, Surita Meldau, Jo Wilmshurst, Büşranur Çavdarlı, Jeannine Heckmann, Patrick F Chinnery, Rita Horvath   +34 more
wiley   +1 more source

Efgartigimod Combined With Steroid Treatment for HAM/TSP: A Case Report

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT HTLV‐1‐associated myelopathy/tropical spastic paraparesis (HAM/TSP) is a progressive neurological disorder with limited treatment options. We report a 54‐year‐old female with decade‐long, progressive HAM/TSP, previously refractory to rituximab, who experienced worsening spastic paraparesis and neurogenic bladder dysfunction.
Jiahui Zeng, Wotu Tian, Jingran Yang, Yanping Yang, Li Cao, Xinghua Luan   +5 more
wiley   +1 more source

Pegylation, as method of production prolonged forms of biopharmaceutical drugs (pegylated granulocyte colony-stimulating factor as case of study)

Тонкие химические технологии, 2014
By now the pegylation of biologically active molecules including proteins with an inert hydrophilic polymer polyethylene glycol (PEG) is an important area in the new generation of prolonged-action pharmaceutical preparations.
I. А. Puchkov, D. I. Bairamashvili, V. I. Shvets   +2 more
doaj  

RNAi‐based genetically engineered rice resistant to black‐streaked dwarf virus does not show adverse genetic effects: A multi‐omics analysis

Plants, People, Planet
Societal Impact Statement Advancements in science and technology enable us to address the challenges of the times: hunger, malnutrition, climate change, and dwindling natural resources.
Chunmeng Huang, Zhi Wang, Pengyu Zhu, Wenjie Xu, Zhixin Du, Yike Qian, Wei Fu   +6 more
doaj   +1 more source