Results 41 to 50 of about 93,674 (295)
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Different applications for genetically modified crops [PDF]
, 2005 65 pages.Congressional hearing on the various uses of biotechnology, with testimonies and prepared statements from producers in the pharmaceutical, forestry, cotton, and papaya ...
United States. Congress. House. Committee on Small Business. Subcommittee on Rural Enterprises, Agriculture, and Technology
core
GMOs, International Law and Indigenous Peoples [PDF]
, 2018 This Article sprung from a desire to discover why—despite scientific uncertainty and the oft-cited precautionary principle in international law—genetically modified organisms are still allowed to spread via international trade and natural ecological ...
Bellevue, Casandia
core +2 more sources
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
A rice exocyst subunit gene SEC3A is required for anther dehiscence
Crop JournalAnther dehiscence controls optimal interaction between pollen and stigma, thereby determining the successful sexual reproduction. The regulators or mechanisms of this process remain elusive.
Ranran Tu +7 more
doaj +1 more source
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Why genetically modified crops? [PDF]
Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences, 2011 This paper is intended to convey the message of the talk I gave at the Theo Murphy meeting at the Kavli Centre in July 2010. It, like the talk, is polemical, and conveys the exasperation felt by a practitioner of genetically modified (GM) plant science at its widespread misrepresentation.
openaire +2 more sources
, 2006 Transgenic Crops describes the basics of genetic modification for agricultural purposes and a brief history of the technology and the governing policies surrounding it.
Jeff Schahczenski, Katherine Adam
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The spatial impact of genetically modified crops [PDF]
, 2008 Although genetically modified (GM) organisms have attracted a great deal of public attention, analysis of their economic impacts has been less common. It is, perhaps, spatial externalities where the divergence between efficient and unregulated outcomes ...
MUNRO Alistair
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