Results 81 to 90 of about 93,674 (295)

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

Screening and Validation of Stable Reference Genes for qRT-PCR Analysis in Epicauta gorhami (Coleoptera: Meloidae)

Insects
Epicauta gorhami is a hypermetamorphic insect that mainly forage soybeans during the adult stage. However, the lack of appropriate references hinders our studying of the gene function in E. gorhami.
Guofeng Yang, Xuetao Yu, Yan Zhang, Jinhua Luo, Xiaofei Li, Li Zhu, Huanhuan Zhang, Lin Jin, Gang Wu, Xiaohong Yan, Chenhui Shen   +10 more
doaj   +1 more source

Effects of the GM Controversy on Iowa Corn-Soybean Farmers' Acreage Allocation Decisions [PDF]

Prior to the 2000 planting season, some industry observers predicted acreage of genetically modified crops would decline dramatically. However, actual 2000 plantings presented a puzzle.
Alexander, Corinne E., Fernandez-Cornejo, Jorge, Goodhue, Rachael E.   +2 more
core   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Biosafety Concerns Involving Genetically Modified Mosquitoes to Combat Malaria and Dengue in Developing Countries [PDF]

, 2011
Malaria and dengue are the most prevalent mosquito-borne infections worldwide. Because traditional vector control methods have proven to be insufficient to control mosquito populations in endemic areas, scientists are actively working in the design of ...
Gostin, Lawrence O., Ostera, Graciela R.
core   +2 more sources

A Depolarizing Leak in Sodium Bicarbonate Cotransporter NBCe1 Causes Brain Edema

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives SLC4A4 encodes electrogenic sodium bicarbonate cotransporter NBCe1, prominently expressed in kidney and brain. Recessive loss‐of‐function variants in SLC4A4 cause proximal renal tubular acidosis, no brain edema. In the brain, NBCe1 is expressed by astrocytes, where it regulates pH and mediates astrocyte volume changes.
Quinty Bisseling, Mark D. Parker, Sven Kerst, Richard A. Pasternack, Jacob Tondreau, Marjolein Breur, Gemma M. van Rooijen‐van Leeuwen, Davide Tonduti, Ettore Salsano, Alejandra Darling, Joanna A. E. van Wijk, Susanna Törnroth‐Horsefield, Marianna Bugiani, Petra J. W. Pouwels, Quinten Waisfisz, Marjo S. van der Knaap, Rogier Min   +16 more
wiley   +1 more source

Biotechnology for Sustainable Crop Production and Protection: Challenges and Opportunities [PDF]

Electronic Journal of Plant Breeding, 2010
In 2009, transgenic crops were grown on 134 million hectares in 25 countries, including India, in six continents by about 14million farmers, marking an 80-fold increase in the area since their first commercialization on 1.7 m ha in the USA and fiveother ...
T. M. Manjunath
doaj  

The StarLink Case: Issues for the Future [PDF]

The disclosure in September 2000 that StarLink corn had been found in the human food supply putfood biotechnology in the public spotlight and caused concern among consumers and food systemstakeholders alike that a product approved only for animal use ...
Taylor, Michael, Tick, Jody
core  

Environmental risk assessment of genetically modified plants - concepts and controversies [PDF]

, 2011
Background and purpose: In Europe, the EU Directive 2001/18/EC lays out the main provisions of environmental risk assessment (ERA) of genetically modified (GM) organisms that are interpreted very differently by different stakeholders. The purpose of this
A Hilbeck, A Hilbeck, A Hilbeck, A Hilbeck, A Hilbeck, A Hilbeck, A Lang, A Raps, A Raybould, A Raybould, AL Cerdeira, ANE Birch, B Lutz, C Hawes, C Zwahlen, C Zwahlen, CB Blackwood, CBD, Council of the European Union, D Saxena, DA Andow, DA Andow, DA Andow, DJ Baird, EC, EC, EFSA, EJ Rosi-Marshall, Environmental Protection Agency (EPA), EP Millstone, EPA Environmental Protection Agency OPPTS 7501P, EurActive, FAO/WHO, J Romeis, J Romeis, J Romeis, J Scheirs, JD Harwood, JD Harwood, KC Nelson, KC Nelson, KR Hayes, KR Hayes, LB Obrist, M Dolezel, M Douville, M Garcia-Alonso, M Mendelsohn, MC Arregui, MR Berenbaum, National Research Council (NRC), OECD, OECD (Organisation for Economic Cooperation and Development), PM Chapman, Royal Society of Canada, T Bøhn, VE Forbes, W Freese   +57 more
core   +1 more source

RNA Sequencing Resolves Cryptic Pathogenic Variants in Mitochondrial Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Mitochondrial diseases are the most common inherited metabolic disorders, characterized by pronounced clinical and genetic heterogeneity that complicates molecular diagnosis. Although DNA‐based sequencing approaches have become standard in genetic testing, up to half of patients remain without a definitive diagnosis.
Zhimei Liu, Xin Duan, Fatemeh Peymani, Jia Wang, Chengjia Bao, Chaolong Xu, Ying Zou, Zixuan Zhang, Yunxi Zhang, Tongyue Li, Martin Pavlov, Junling Wang, Minhan Song, Tianyu Song, Xiaodi Han, Mingxi Sun, Danmin Shen, Ruoyu Duan, Huafang Jiang, Manting Xu, Holger Prokisch, Fang Fang   +21 more
wiley   +1 more source