Results 91 to 100 of about 277,970 (322)

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Specific transfection of inflamed brain by macrophages: a new therapeutic strategy for neurodegenerative diseases. [PDF]

PLoS ONE, 2013
The ability to precisely upregulate genes in inflamed brain holds great therapeutic promise. Here we report a novel class of vectors, genetically modified macrophages that carry reporter and therapeutic genes to neural cells.
Matthew J Haney, Yuling Zhao, Emily B Harrison, Vivek Mahajan, Shaheen Ahmed, Zhijian He, Poornima Suresh, Shawn D Hingtgen, Natalia L Klyachko, R Lee Mosley, Howard E Gendelman, Alexander V Kabanov, Elena V Batrakova   +12 more
doaj   +1 more source

Approaches for timeline reductions in pathogenesis studies using genetically modified mice

Microbiology Spectrum, 2023
Although genetically modified mouse models have long been a powerful tool for microbiology research, the manipulation of the mouse genome is expensive, time consuming, and has historically remained the domain of dedicated animal facilities.
Samantha Skavicus, Nicholas S. Heaton
doaj   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

1st INCF Workshop on Genetic Animal Models for Brain Diseases [PDF]

, 2011
The INCF Secretariat organized a workshop to focus on the “role of neuroinformatics in the processes of building, evaluating, and using genetic animal models for brain diseases” in Stockholm, December 13–14, 2009.
Holm Graessner, Olaf Riess
core   +2 more sources

Translational outcomes in a full gene deletion of ubiquitin protein ligase E3A rat model of Angelman syndrome. [PDF]

, 2020
Angelman syndrome (AS) is a rare neurodevelopmental disorder characterized by developmental delay, impaired communication, motor deficits and ataxia, intellectual disabilities, microcephaly, and seizures. The genetic cause of AS is the loss of expression
Adhikari, A, Anderson, AE, Beitnere, U, Berg, EL, Born, HA, Cameron, DL, Copping, NA, Deng, P, Dindot, SV, Ellegood, J, Fenton, TA, Fink, KD, Harris, S, Lee, RD, Lerch, JP, Nash, KR, Nieman, BJ, Noakes, LS, O'Geen, H, Pedersen, LR, Peters, MM, Petkova, SP, Pride, MC, Segal, DJ, Shen, Y, Silverman, JL, Weeber, EJ, Wöhr, M   +27 more
core   +2 more sources

Simultaneous Detection of Multiple Transgenes for Genetically-Modified Mouse Strains

Experimental Animals, 2009
Recent advances in the genetic manipulation of mice have enabled us to generate transgenic and knockout mice. However, it is not easy to maintain these genetically-modified mice with the high-quality necessary to meet both scientific and legal requirements. RIKEN BRC has collected various transgenic, knockout, and conditional knockout mice.
Hatsumi, Nakata, Tomomi, Hashimoto, Yukiko, Seki, Kazuyuki, Mekada, Yuichi, Obata, Atsushi, Yoshiki   +5 more
openaire   +3 more sources

Sharpened cochlear tuning in a mouse with a genetically modified tectorial membrane [PDF]

Nature Neuroscience, 2007
Frequency tuning in the cochlea is determined by the passive mechanical properties of the basilar membrane and active feedback from the outer hair cells, sensory-effector cells that detect and amplify sound-induced basilar membrane motions. The sensory hair bundles of the outer hair cells are imbedded in the tectorial membrane, a sheet of extracellular
Russell, Ian, Lukashkina, Victoria, Lukashkin, Andrei, Legan, P.K., Goodyear, R.J., Richardson, G.P.   +5 more
openaire   +2 more sources

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source

A Case Study of Using Assisted Reproductive Technology to Rescue Genetically Modified Mice with Reproductive Disorder Phenotypes

Shiyan dongwu yu bijiao yixue
ObjectiveThe utilization of assisted reproductive technology to rescue genetically modified mouse strains with reproductive disorders provides a reference for improving techniques to preserve valuable experimental mouse strains.MethodsIn vitro ...
WANG Qianqian, TAO Sijue, WEI Zhen, JIN Huihui, LIU Ping, WANG Lie   +5 more
doaj   +1 more source