Results 161 to 170 of about 226,675 (297)

Current and Future Cornea Chip Models for Advancing Ophthalmic Research and Therapeutics

Advanced Biology, EarlyView.
This review analyzes cornea chip technology as an innovative solution to corneal blindness and tissue scarcity. The examination encompasses recent developments in biomaterial design and fabrication methods replicating corneal architecture, highlighting applications in drug screening and disease modeling while addressing key challenges in mimicking ...
Minju Kim, Kanghoon Choi, Amy Lin, Jungkyu Kim   +3 more
wiley   +1 more source

Can a genetically-modified organism-containing diet influence embryo development? A preliminary study on pre-implantation mouse embryos

, 2009
Barbara Cisterna, F Flach, L. Vecchio, SML Barabino, Serafina Battistelli, TE Martin, Manuela Malatesta, Marco Biggiogera   +7 more
openalex   +2 more sources

Activation of SIRT1 Reduces Renal Tubular Epithelial Cells Fibrosis in Hypoxia Through SIRT1‐FoxO1‐FoxO3‐Autophagy Pathway

Advanced Biology, EarlyView.
Hypoxia promotes the epithelial‐mesenchymal transition (EMT) of renal tubular epithelial cells via the SIRT1‐FoxO1‐FoxO3‐autophagy pathway, thereby resulting in the fibrosis of renal tubular epithelial cells. Activation of SIRT1 or induction of autophagy inhibits this process, alleviating hypoxia‐induced fibrosis.
Guangyu Wang, Lijuan Zhang, Jiaorong Tan, Fei Li, Yishan Jin, Limei He, Xin Yang   +6 more
wiley   +1 more source

Lipoprotein Size and Susceptibility to Atherosclerosis — Insights from Genetically Modified Mouse Models [PDF]

, 2008
Murielle M. Véniant, Anne P. Beigneux, André Bensadoun, Loren G. Fong, Stephen G. Young   +4 more
openalex   +1 more source

The Potential for Extracellular Vesicles in Nanomedicine: A Review of Recent Advancements and Challenges Ahead

Advanced Biology, EarlyView.
Extracellular vesicles (EVs) play a dual role in diagnostics and therapeutics, offering innovative solutions for treating cancer, cardiovascular, neurodegenerative, and orthopedic diseases. This review highlights EVs’ potential to revolutionize personalized medicine through specific applications in disease detection and treatment.
Farbod Ebrahimi, Anjali Kumari, Samaneh Ghadami, Saqer Al Abdullah, Kristen Dellinger   +4 more
wiley   +1 more source

Murine Models and Human Cell Line Models to Study Altered Dynamics of Ovarian Follicles in Polycystic Ovary Syndrome

Advanced Biology, EarlyView.
The manuscript examines preclinical murine and human models to study polycystic ovary syndrome (PCOS), delving into the cellular and molecular mechanisms underlying altered ovarian follicular dynamics. It explores the cellular interactions involved in normal and PCOS ovaries and outlines the current and novel strategies in the search for preclinical ...
Arturo Bevilacqua, Cristiano Giuliani, Giovanna Di Emidio, Samuel H Myers, Vittorio Unfer, Carla Tatone   +5 more
wiley   +1 more source

Host genetics maps to behaviour and brain structure in developmental mice

Behavioral and Brain Functions
Gene-environment interactions in the postnatal period have a long-term impact on neurodevelopment. To effectively assess neurodevelopment in the mouse, we developed a behavioural pipeline that incorporates several validated behavioural tests to measure ...
Sarah Asbury, Jonathan K. Y. Lai, Kelly C. Rilett, Zeeshan Haqqee, Benjamin C. Darwin, Jacob Ellegood, Jason P. Lerch, Jane A. Foster   +7 more
doaj   +1 more source

HMGB1 Derived from the Pyroptotic Microenvironment Promotes Macrophage Extracellular Traps in Hirschsprung‐Associated Enterocolitis

Advanced Biology, EarlyView.
HMGB1 derived from the pyroptotic environment in Hirschsprung‐associated enterocolitis mediates the formation of macrophage extracellular traps through TLR4 ‐p38 MAPK/p65 NF‐kB signaling pathways. Macrophage extracellular traps induce increased ROS production and pyroptosis of colonic epithelial cells.
Rui Zhang, Jing Li, Lili Song, Liya Pan, Chengchen Zhang, Zhiyan Zhan, Li Hong   +6 more
wiley   +1 more source

Determination of Sulfotransferase Forms Involved in the Metabolic Activation of the Genotoxicant 1-Hydroxymethylpyrene Using Bacterially Expressed Enzymes and Genetically Modified Mouse Models

, 2014
Carolin Bendadani, Walter Meinl, Bernhard H. Monien, Gisela Dobbernack, Simone Florian, Wolfram Engst, Tobias Nolden, Heinz Himmelbauer, Hansruedi Glatt   +8 more
openalex   +1 more source

354. Genetically Modified Human Mesenchymal Stromal Cell (MSC) Delivery Improved Glucose Tolerance in Diet Induced Obese (DIO) Mouse Models [PDF]

, 2016
Cleyton C. Domingues, Nabanita Kundu, Neeki Ahmadi, Sabyasachi Sen   +3 more
openalex   +1 more source