Results 261 to 270 of about 279,987 (320)

Perfusion Bioreactor Culture Incorporating Mechanical Confinement Enhances Mesenchymal Stem Cell Extracellular Vesicle Production and Wound Healing Potential

Advanced Materials Technologies, EarlyView.
Scalable manufacturing challenges and limited potency remain two of the most intransigent issues limiting clinical translation of EV therapeutics. Mechanical cues can induce phenotypic changes and increased vesiculation in EV source cells without the use of extraneous reagents, chemicals, and/or cargo, thereby potentially drastically improving the ...
Emily H. Powsner, Raith Nowak, Stephanie M. Kronstadt, Nicholas H. Pirolli, Talia J. Solomon, Kristin Nikolov, William Pieper Holeman, Ian M. Smith, Kimberly M. Stroka, John P. Fisher, Steven M. Jay   +10 more
wiley   +1 more source

MDISCO: A High-Throughput Tissue-Clearing Protocol for Preservation of Endogenous Fluorescence in Whole Mouse Brains. [PDF]

Bio Protoc
Martinez M, Thornberry J, Ozawa A, Toll L.   +3 more
europepmc   +1 more source

High‐Throughput 3D Matrigel‐based Droplet Microfluidics for Single‐Cell Function‐to‐Omics Analysis of Cytotoxic Immune Cells in Solid Tumor Interactions

Advanced Materials Technologies, EarlyView.
A 3D Matrigel‐based droplet microfluidics platform that allows physiologically relevant analysis of single immune‐tumor interactions in solid tumors. By integrating real‐time functional imaging with fluorescence‐activated droplet sorting and RNA sequencing, the system links immune cytotoxic behavior to transcriptomic profiles, providing a scalable ...
Christina Sharkey, Harry Akligoh, Michael Finocchiaro, Abhishek Srihari Rampelli, Zongwei Wang, Aria F. Olumi, Tania Konry   +6 more
wiley   +1 more source

Engineered bacteria: a novel era for metabolic, cardiovascular and cerebrovascular diseases therapy. [PDF]

Front Cardiovasc Med
Wu Y, Sang R, Chen X, Wang S.
europepmc   +1 more source

A novel carcinogenic mouse model by site-directed insertion of tandem human HRAS large DNA fragment into 15E1 site. [PDF]

Animal Model Exp Med
Liu S, Yang Y, Huo G, Yang Zhao H, Ling C, Wang Y, Zhai S, Sun X, Gu W, Cao Y, Gong W, Wang S, Fan C.   +12 more
europepmc   +1 more source

Consideration of sex as a biological variable over the history of the 5xFAD Alzheimer's Disease mouse model. [PDF]

Biol Sex Differ
Neuharth JI, Hernandez KS, Bernholtz J, Edwards H, Stewart A.   +4 more
europepmc   +1 more source

Exogenous CD55 Expression on Membrane-Wrapped Nanoparticles Unexpectedly Increases Spleen Tropism and Immune Cell Uptake <i>In Vivo</i>. [PDF]

ACS Nano Med
Sterin EH, Kramarenko GC, Roy Chowdhury C, Tendulkar SP, Li K, Chaya T, Muscat-Rivera J, Melamed JR, Day ES.   +8 more
europepmc   +1 more source

Proof-of-principle of NF1 gene therapy in plexiform neurofibroma xenograft mouse models. [PDF]

Commun Biol
Hewa Bostanthirige D, Plante C, Caron M, Gascon S, Lévesque M, Poirier C, Deschenes M, Sabo Vatasescu JP, Chabot B, Geha S, Laurent B, Brosseau JP.   +11 more
europepmc   +1 more source

The Scientific Case for Animal Models: A Perspective From Musculoskeletal Researchers. [PDF]

FASEB Bioadv
Hadjiargyrou M, Hildreth BE, Ko F, Sankar U, Yang T.   +4 more
europepmc   +1 more source