Results 291 to 300 of about 279,987 (320)

Genetic and Environmental Modifiers of Alzheimers Disease Phenotypes in the Mouse

Current Alzheimer Research, 2006
As a group, strains of laboratory mice carrying Alzheimer's disease (AD)-related transgenes are currently the most widely studied animal models of AD. Many AD mouse models carrying the same or similar transgene constructs demonstrate strikingly different phenotypic responses to transgene expression, mimicking the apparent genetic complexity of AD ...
Davis, Ryman, Bruce T, Lamb
openaire   +2 more sources

Genetic Modifiers of Cardiac Development 22q11DS Mouse Models

The FASEB Journal, 2016
Over 70% of patients with 22q11.2 Deletion Syndrome (22q11DS) have congenital heart defects. The prevalence and severity of these defects make it critical for us to strive to understand the underlying mechanism of the syndrome by elucidating the gene pathways that are involved in heart development, as their disruption may lead to ...
openaire   +1 more source

Genetically modified mouse models to investigate thyroid development, function and growth

Best Practice & Research Clinical Endocrinology & Metabolism, 2018
The thyroid gland produces thyroid hormones (TH), which are essential regulators for growth, development and metabolism. The thyroid is mainly controlled by the thyroid-stimulating hormone (TSH) that binds to its receptor (TSHR) on thyrocytes and mediates its action via different G protein-mediated signaling pathways.
Kero Andreina, Löf Christoffer, Kero Jukka, Patyra Konrad, Kero Andreina, Kero Jukka   +5 more
openaire   +4 more sources

Genetic modifiers that aggravate the neurological phenotype of the wobbler mouse

Neuroreport, 2002
The autosomal recessive mutation wobbler of the mouse (phenotype WR; genotype wr/wr) causes muscular atrophy due to motoneuron degeneration with 100% penetrance on the standard Mus musculus laboratorius C57BL/6J background. In inter- and backcrosses with M. m.
Ulbrich, Michael, Schmidt, Volker, Ronsiek, Melanie, Mussmann, Anke, Bartsch, Jörg, Augustin, Martin, Jockusch, Harald, Schmitt-John, Thomas   +7 more
openaire   +3 more sources

Genetically Modified Mouse Models for Biomarker Discovery and Preclinical Drug Testing

Clinical Cancer Research, 2012
Abstract The ability to grow pluripotent mouse embryonic stem cells in culture, and to introduce precise genetic modifications into those cells through gene targeting, has greatly facilitated the generation of mouse models of human disease. This technology is playing a particularly important role in cancer research.
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Probability Learning In Genetically Modified Mouse Lines

Laboratornye Zhivotnye dlya nauchnych issledovanii (Laboratory Animals for Science), 2018
A.A. Tkachenko, S.V. Ranneva, L.V. Loskutova, T.V. Lipina   +3 more
openaire   +1 more source

Genetically Modified NAT Mouse Models

2018
Kim S. Sugamori, Denis M. Grant
openaire   +1 more source

Genetically modified mouse as an experimental model in biomedicine

2001
no ...
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The mighty mouse: genetically engineered mouse models in cancer drug development

Nature Reviews Drug Discovery, 2006
Norman Sharpless, Ronald A Depinho
exaly  

The ascent of mouse: advances in modelling human depression and anxiety

Nature Reviews Drug Discovery, 2005
John Cryan, Andrew Holmes
exaly