Results 71 to 80 of about 6,970,054 (353)

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Lifestyle and psychosocial associations with cognition at the cusp of midlife using twins and siblings

Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring
INTRODUCTION This study investigates the relationship between cognitive functioning and 59 modifiable and intrinsic factors at the cusp of midlife. METHODS We analyzed data from 1221 participants in the Colorado Adoption/Twin Study of Lifespan behavioral
Anqing Zheng, Naomi P. Friedman, Daniel E. Gustavson, Robin P. Corley, Sally J. Wadsworth, Chandra A. Reynolds   +5 more
doaj   +1 more source

A Review on the Cognitive Neuroscience of Autism [PDF]

, 2005
With increased recognition in the media, heightened prevalence, and advances in research technologies, investigation into the causes of autism has broadened in recent years.
Koyama, Alain
core  

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Pergola: Boosting Visualization and Analysis of Longitudinal Data by Unlocking Genomic Analysis Tools

iScience, 2018
Summary: The growing appetite of behavioral neuroscience for automated data production is prompting the need for new computational standards allowing improved interoperability, reproducibility, and shareability.
Jose Espinosa-Carrasco, Ionas Erb, Toni Hermoso Pulido, Julia Ponomarenko, Mara Dierssen, Cedric Notredame   +5 more
doaj   +1 more source

Heritability of pain catastrophizing and associations with experimental pain outcomes: a twin study [PDF]

, 2015
This study used a twin paradigm to examine genetic and environmental contributions to pain catastrophizing and the observed association between pain Catastrophizing and cold-pressor task (CPT) outcomes. Male and female monozygotic (n = 206) and dizygotic
Afari, Afari, Angst, Belfer, Boomsma, Busjahn, Crombez, Diatchenko, Finan, Gatchel, George, Goubert, Goubert, Horsham, Hur, Jensen, Karsdorp, Kato, Keefe, Kendler, Kozak, Kraljevic, Leeuw, McGue, Mogil, Nielsen, Norbury, Osman, Pavlakovic, Quartana, Rijsdijk, Seminowicz, Smeets, Stein, Strachan, Sullivan, Sullivan, Sullivan, Sullivan, Sullivan, Sullivan, Trost, Trost, Turk, Turner, Van Damme, Van Damme, Van Damme, Vassend, Verhoeven, Vervoort, Vervoort, Vervoort, Weissman-Fogel, Wilson   +54 more
core   +2 more sources

Beyond Biodiversity: Can Environmental DNA (eDNA) Cut It as a Population Genetics Tool?

Genes, 2019
Population genetic data underpin many studies of behavioral, ecological, and evolutionary processes in wild populations and contribute to effective conservation management.
Clare M. Adams, M. Knapp, N. Gemmell, Gert‐Jan Jeunen, M. Bunce, M. Lamare, H. Taylor   +6 more
semanticscholar   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Moving from information and collaboration to action: report from the 3rd International Dog Health Workshop, Paris in April 2017 [PDF]

, 2017
Background Breed-related health problems in dogs have received increased focus over the last decade. Responsibility for causing and/or solving these problems has been variously directed towards dog breeders and kennel clubs, the veterinary profession ...
A Bartels, AIDAP, AJ Clarke, APGAW, APGAW, APGAW, C Greko, C Mellersh, D O'Neill, DG O'Neill, DG O'Neill, DG O’Neill, FW Nicholas, G Leroy, German Kennel Club (VDH), International Partnership for Dogs (IPFD), J Donner, J Serpell, JE Simmering, JG Scott, JP Scott, JY Kwan, K Arman, L Asher, L Beever, L Farrell, L Lilja-Maula, LM Collins, LM Collins, N Couto, NJ Beausoleil, O Ljungquist, P Bateson, P Sandøe, PC Bartlett, PD McGreevy, PD McGreevy, R Packer, R Proctor, R Ryan, RMA Packer, RMA Packer, RMA Packer, RMA Packer, S Ghirlanda, S Ghirlanda, T Pires dos Santos, The Swedish Kennel Club, VJ Adams, ÅA Hedhammar, ÅA Hedhammar   +50 more
core   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source