Results 81 to 90 of about 6,970,054 (353)
Scientific ReportsThe study of partner resemblance has widespread implications in the social and natural sciences. To date, the vast majority of such research has focused on opposite-sex couples.
Tanya B. Horwitz +2 more
doaj +1 more source
Multi-omic and multi-species meta-analyses of nicotine consumption
Translational Psychiatry, 2021 Cross-species translational approaches to human genomic analyses are lacking. The present study uses an integrative framework to investigate how genes associated with nicotine use in model organisms contribute to the genetic architecture of human tobacco
Rohan H. C. Palmer +11 more
doaj +1 more source
The expression and assessment of emotions and internal states in individuals with severe or profound intellectual disabilities [PDF]
, 2011 The expression of emotions and internal states by individuals with severe or profound intellectual disabilities is a comparatively under-researched area. Comprehensive or standardised methods of assessing or understanding the emotions and internal states
Adams, Dawn, Christopher, Oliver
core +1 more source
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
F1000Research, 2012 Precise spatial and temporal manipulation of neural activity in specific genetically defined cell populations is now possible with the advent of optogenetics.
Shinya Nakamura +4 more
doaj +1 more source
Early intervention combined with targeted treatment promotes cognitive and behavioral improvements in young children with fragile x syndrome. [PDF]
, 2012 Fragile X syndrome (FXS) is the most common inherited cause of intellectual disability due to an expansion in the full mutation range (>200 CGG repeats) of the promoter region of the FMR1 gene leading to gene silencing.
Borodyanskara, Mariya +3 more
core +3 more sources
FEBS Letters, EarlyView.Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson +7 more
wiley +1 more source
Nature Communications, 2020 People differ in their susceptibility to stressors, but it is difficult to know a priori who has a higher vulnerability. Here, the authors show that machine learning algorithms applied to locomotor data from people’s exploration of virtual reality ...
João Rodrigues +4 more
doaj +1 more source
The hippocampus encodes delay and value information during delay-discounting decision making
eLife, 2020 The hippocampus, a region critical for memory and spatial navigation, has been implicated in delay discounting, the decline in subjective reward value when a delay is imposed.
Akira Masuda +6 more
doaj +1 more source
Structural biology of ferritin nanocages
FEBS Letters, EarlyView.Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley +1 more source