Results 121 to 130 of about 5,647,381 (313)

RELAGH - the challenge of having a scientific network in Latin America: an account from the presidents

Genetics and Molecular Biology, 2014
Latin America and the Caribbean region make up one of the largest areas of the world, and this region is characterized by a complex mixture of ethnic groups sharing Iberian languages.
Augusto Rojas-Martínez, Alejandro Giraldo-Ríos, Gerardo Jiménez-Arce, Aída Falcón de Vargas, Roberto Giugliani   +4 more
doaj   +1 more source

Structural insights into lacto‐N‐biose I recognition by a family 32 carbohydrate‐binding module from Bifidobacterium bifidum

FEBS Letters, EarlyView.
Bifidobacterium bifidum establishes symbiosis with infants by metabolizing lacto‐N‐biose I (LNB) from human milk oligosaccharides (HMOs). The extracellular multidomain enzyme LnbB drives this process, releasing LNB via its catalytic glycoside hydrolase family 20 (GH20) lacto‐N‐biosidase domain.
Xinzhe Zhang, Naoki Sunagawa, Toma Kashima, Kiyohiko Igarashi, Akimasa Miyanaga, Shinya Fushinobu   +5 more
wiley   +1 more source

Human and medical genetics in Brazil

Genetics and Molecular Biology, 2000
The present paper intends to be a brief historical analysis of the conditions for the development of Human and Medical Genetics in Brazil.
Beiguelman Bernardo
doaj  

Recommendations for reporting of secondary findings in clinical exome and genome sequencing, 2021 update: a policy statement of the American College of Medical Genetics and Genomics (ACMG)

Genetics in Medicine, 2021
David T. Miller, Kristy Lee, A. Gordon, L. Amendola, Kathy Adelman, S. Bale, W. Chung, M. Gollob, S. Harrison, G. Herman, R. E. Hershberger, T. Klein, K. Mckelvey, C. Richards, C. Vlangos, D. Stewart, M. Watson, C. Martin   +17 more
semanticscholar   +1 more source

Molecular bases of circadian magnesium rhythms across eukaryotes

FEBS Letters, EarlyView.
Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley   +1 more source

Human Genetic Variation: A Flipped Classroom Exercise in Cultural Competency

MedEdPORTAL, 2013
Introduction Our understanding of human genetic variation has deepened through the Human Genome and International HapMap projects, which gave us a high-resolution view of human genetic variation and ancestry.
Shoumita Dasgupta, Katherine Tuttle
doaj   +1 more source

An open resource of structural variation for medical and population genetics

, 2019
Structural variants (SVs) rearrange the linear and three-dimensional organization of the genome, which can have profound consequences in evolution, diversity, and disease.
Ryan L. Collins, H. Brand, K. Karczewski, Xuefang Zhao, Jessica Alföldi, A. Khera, L. Francioli, L. Gauthier, Harold Wang, N. Watts, M. Solomonson, A. O’Donnell-Luria, Alexander Baumann, Ruchi Munshi, Chelsea Lowther, Mark Walker, Christopher W. Whelan, Yongqing Huang, Ted Brookings, Ted Sharpe, M. Stone, E. Valkanas, Jack M. Fu, G. Tiao, Kristen M. Laricchia, C. Stevens, N. Gupta, L. Margolin, J. Spertus, K. Taylor, Henry J. Lin, S. Rich, W. Post, Y. Ida Chen, J. Rotter, C. Nusbaum, A. Philippakis, E. Lander, S. Gabriel, B. Neale, S. Kathiresan, M. Daly, E. Banks, D. MacArthur, M. Talkowski   +44 more
semanticscholar   +1 more source

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

Multi-ancestry study of blood lipid levels identifies four loci interacting with physical activity. [PDF]

, 2019
Many genetic loci affect circulating lipid levels, but it remains unknown whether lifestyle factors, such as physical activity, modify these genetic effects.
Alver, Maris, Amin, Najaf, Amini, Marzyeh, Arnett, Donna K, Aschard, Hugues, Aslibekyan, Stella, Bartz, Traci M, Bentley, Amy R, Bielak, Lawrence F, Boerwinkle, Eric, Boissel, Mathilde, Brown, Michael R, Brumat, Marco, Cade, Brian, Campbell, Archie, Canouil, Mickaël, Chai, Jin Fang, Chasman, Daniel I, Chen, Xu, Chen, Yii-Der Ida, Concas, Maria Pina, Connell, John, de Las Fuentes, Lisa, de Mutsert, Renée, de Silva, H Janaka, de Vries, Paul S, Demirkan, Ayşe, Ding, Jingzhong, Divers, Jasmin, Dorajoo, Rajkumar, Eaton, Charles B, Evangelou, Evangelos, Faul, Jessica D, Feitosa, Mary F, Fisher, Virginia, Franceschini, Nora, Friedlander, Yechiel, Gabriel, Kelley P, Gao, Chuan, Ghanbari, Mohsen, Giulianini, Franco, Graff, Mariaelisa, Gu, Chi Charles, Gu, Dongfeng, Guo, Xiuqing, Harris, Sarah E, Harris, Tamara B, Hartwig, Fernando P, He, Jiang, He, Meian, Heikkinen, Sami, Heng, Chew-Kiat, Horimoto, Andrea RVR, Hsu, Fang-Chi, Hunt, Steven C, Ikram, M Arfan, Jackson, Anne U, Jakupović, Hermina, Jonas, Jost B, Kho, Minjung, Kilpeläinen, Tuomas O, Koh, Woon-Puay, Komulainen, Pirjo, Kraja, Aldi T, Krieger, Jose E, Kühnel, Brigitte, Laguzzi, Federica, Li, Changwei, Li, Xiaoyin, Lohman, Kurt K, Lyytikäinen, Leo-Pekka, Manning, Alisa, Marten, Jonathan, Musani, Solomon K, Nolte, Ilja M, Noordam, Raymond, Ntalla, Ioanna, Rauramaa, Rainer, Riaz, Muhammad, Richard, Melissa, Robino, Antonietta, Rueedi, Rico, Schwander, Karen, Sim, Xueling, Smith, Albert V, Stringham, Heather M, Sung, Yun Ju, Tajuddin, Salman M, Takeuchi, Fumihiko, van der Most, Peter J, Varga, Tibor V, Verweij, Niek, Vojinovic, Dina, Wang, Heming, Wang, Zhe, Ware, Erin B, Wen, Wanqing, Winkler, Thomas W, Yanek, Lisa R, Zhao, Jing Hua   +99 more
core  

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source