Results 71 to 80 of about 5,512,004 (328)

ERBIN limits epithelial cell plasticity via suppression of TGF‐β signaling

FEBS Letters, EarlyView.
In breast and lung cancer patients, low ERBIN expression correlates with poor clinical outcomes. Here, we show that ERBIN inhibits TGF‐β‐induced epithelial‐to‐mesenchymal transition in NMuMG breast and A549 lung adenocarcinoma cell lines. ERBIN suppresses TGF‐β/SMAD signaling and reduces TGF‐β‐induced ERK phosphorylation.
Chao Li, Gerard van der Zon, Peter ten Dijke, Tong Shen   +3 more
wiley   +1 more source

The Design and Consideration of Medical Genetics Training Courses for Clinical Physicians Specializing in Rare Diseases

罕见病研究
The diagnosis and treatment of rare diseases have long been significant challenges in the medical practice. With the rapid development of genomics and genetics, medical genetics has been widely applied in the diagnosis and treatment of rare diseases ...
LIU Yaping, SHEN Min, ZHANG Shuyang
doaj   +1 more source

Texas Physicians\u27 Awareness and Utilization of Genetic Services [PDF]

, 2015
The number of disorders for which genetic testing is available has increased nearly 500% in the past 15 years. Access to the majority of genetic tests and services hinges on physicians’ ability to identify patients at risk for genetic disease and provide
Jenevein, Callie L
core   +1 more source

Evaluation of a candidate breast cancer associated SNP in ERCC4 as a risk modifier in BRCA1 and BRCA2 mutation carriers. Results from the Consortium of Investigators of Modifiers of BRCA1/BRCA2 (CIMBA) [PDF]

, 2009
Background: In this study we aimed to evaluate the role of a SNP in intron 1 of the ERCC4 gene (rs744154), previously reported to be associated with a reduced risk of breast cancer in the general population, as a breast cancer risk modifier in BRCA1 and ...
A Allavena, A Antoniou, A B Spurdle, A C Antoniou, A E Toland, A K Godwin, A Meindl, A Miron, A Osorio, A Osorio, A van den Ouweland, A Viel, A-C Spiess, A-M Gerdes, AC Antoniou, AC Antoniou, B Arver, B Fiebig, B Kaufman, B Malmer, B Versmold, C Casella, C Cassini, C Engel, C F Singer, C I Szabo, C Kiyohara, C Luccarini, C T Oliver, D F Easton, D Ford, D Frost, D G Cruger, D G Evans, D Goldgar, D Gschwantler-Kaulich, D Muller, D Niederacher, D Schaefer, D Stoppa-Lyonnet, D Yannoukakos, DF Easton, DF Easton, E Dagan, E Friedman, E M John, E N Imyanitov, EB Gómez García, F B L Hogervorst, F Douglas, F J Couch, F Lalloo, F Lejbkowicz, F Révillion, G C Rodriguez, G Chenevix-Trench, G Chenevix-Trench, G Pfeiler, G Pichert, G Pita, G Rennert, H Deißler, H Jernström, H Nevanlinna, H Ozcelik, H T Lynch, I L Andrulis, J Basil, J Beesley, J Benítez, J Brunet, J Cook, J F Boggess, J L Hopper, J Simard, J T Wijnen, J-P Fricker, J-P Peyrat, K Claes, K Kosarin, K L Nathanson, K Lange, K Offit, K Wakeley, L Barjhoux, L Foretova, L McGuffog, L Olivier-Faivre, L Tizzoni, LE Mechanic, M A Caligo, M B Terry, M Barile, M Cook, M Daly, M de la Hoya, M Garcia-Closas, M H Greene, M Montagna, M Piedmonte, M S Askmalm, M Thomassen, M Zikan, MM Gaudet, N Arnold, N Ditsch, N Lindor, N Weerasooriya, O Barnett-Griness, O M Sinilnikova, O T Johannsson, P E Schwartz, P J Morrison, P Mai, P Peterlongo, P Radice, R Eeles, R Gershoni-Baruch, R K Schmutzler, R L Milne, R Varon-Mateeva, RL Milne, RL Milne, S Buys, S Chen, S Cohen, S Giraud, S Healey, S Hodgson, S Hooker, S L Neuhausen, S M Domchek, S Manoukian, S Peock, S V Blank, S Verhoef, T Caldes, T Heikkinen, T Kirchhoff, T Kontorovich, T Ramón y Cajal, Thomas v O Hansen, TR Smith, U G Froster, U Hamann, V Moncoutier, V Moreno, X Chen, X Wang, Y C Ding, Y Laitman, Y Yassin   +151 more
core   +4 more sources

Medical genetics education in the midst of the COVID‐19 pandemic: Shared resources

American Journal of Medical Genetics. Part A, 2020
In the midst of the COVID‐19 pandemic, it is appropriate that our focus is on patient care and preparation. However, the genetics community is well poised to fill in the educational gap created by medical students transitioning to limiting patient ...
D. Regier, Wendy E Smith, H. M. Byers
semanticscholar   +1 more source

Exploring lipid diversity and minimalism to define membrane requirements for synthetic cells

FEBS Letters, EarlyView.
Designing the lipid membrane of synthetic cells is a complex task, in which its various roles (among them solute transport, membrane protein support, and self‐replication) should all be integrated. In this review, we report the latest top‐down and bottom‐up advances and discuss compatibility and complexity issues of current engineering approaches ...
Sergiy Gan, Victoria Scarpelli, Marten Exterkate   +2 more
wiley   +1 more source

The Growth and Development of Genetics at MCV [PDF]

, 1977
Genetics was well established at the Medical College of Virginia by the time I joined the faculty in 1960. At least one course in genetics was required of students in the Schools of Medicine, Dentistry, Pharmacy, and Nursing.
Townsend, J. Ives
core   +1 more source

Ergothioneine supplementation improves pup phenotype and survival in a murine model of spinal muscular atrophy

FEBS Letters, EarlyView.
Spinal muscular atrophy (SMA) is a genetic disease affecting motor neurons. Individuals with SMA experience mitochondrial dysfunction and oxidative stress. The aim of the study was to investigate the effect of an antioxidant and neuroprotective substance, ergothioneine (ERGO), on an SMNΔ7 mouse model of SMA.
Francesca Cadile, Daniela Ratto, Giorgia Rastelli, Ottavia Eleonora Ferraro, Caterina Temporini, Sunil Kumar, Simona Boncompagni, Paola Rossi, Monica Canepari   +8 more
wiley   +1 more source

Medical genetics teaching in Iranian medical schools, especially Ahvaz, south of Iran

Journal of Advances in Medical Education and Professionalism, 2014
Introduction: Physicians have to visit, diagnose and refer patients with genetic disorders, so they need to be familiar with the basics and indications of genetic tests.
MAHDI BIJANZADEH
doaj  

Human brain harbors single nucleotide somatic variations in functionally relevant genes possibly mediated by oxidative stress [version 3; referees: 2 approved]

F1000Research, 2017
Somatic variation in DNA can cause cells to deviate from the preordained genomic path in both disease and healthy conditions. Here, using exome sequencing of paired tissue samples, we show that the normal human brain harbors somatic single base ...
Anchal Sharma, Asgar Hussain Ansari, Renu Kumari, Rajesh Pandey, Rakhshinda Rehman, Bharati Mehani, Binuja Varma, Bapu K. Desiraju, Ulaganathan Mabalirajan, Anurag Agrawal, Arijit Mukhopadhyay   +10 more
doaj   +1 more source