Results 161 to 170 of about 6,951,992 (282)

HSP70 governs permeability and mechanotransduction in primary human endothelial cells

FEBS Open Bio, EarlyView.
HSP70 chemical inhibition reduces endothelial cell proliferation and increases permeability, the latter supported by normal interendothelial junctional protein distribution. HSP70 also plays a role in shear stress response, a hemodynamic force naturally present in blood vessels and correlated with vessel protection.
Andrea Pinto‐Martinez, Everton G. Melo, Isadora C. B. Pavan, Percíllia V. S. Oliveira, Luiza B. C. T. Coimbra, Thaís L. S. Araujo   +5 more
wiley   +1 more source

Impact of erroneous marker data on the accuracy of narrow-sense heritability. [PDF]

Genetics
Sagariya C, Bittner V, Pook T, Roy A, Lstibůrek M.   +4 more
europepmc   +1 more source

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

No association of Alzheimer disease with the joint effect of <i>HFE</i> and <i>TF</i> in the mid-western Amish. [PDF]

J Med Genet
Liu Y, Song YE, Lynn A, Wang W, Miskimen K, Fuzzell SL, Hochstetler SD, Laux RA, Caywood LJ, Clouse JE, Herington SD, Wang P, Gulyayev AV, Dorfsman DA, Moore NC, Main LR, Prough MB, Zaman AF, Adams LD, Whitehead P, Ogrocki P, Lerner AJ, Vance J, Cuccaro ML, Scott WK, Pericak-Vance MA, Haines JL.   +26 more
europepmc   +1 more source

Molecular determinants of signal transduction in tropomyosin receptor kinases

FEBS Open Bio, EarlyView.
Tropomyosin receptor kinases control critical neuronal functions, but how do the same receptors produce diverse cellular responses? This review explores the structural mechanisms behind Trk signaling diversity, focusing on allosteric modulation and ligand bias.
Giray Enkavi
wiley   +1 more source

Genetic mapping and candidate gene identification for key physiological traits associated with heat tolerance in wheat (Triticum aestivum L.) using a MAGIC population. [PDF]

PLoS One
Bag A, Krishna H, Kumar P N V, Meena S, Devate NB, Kumar S, Patil R, Reddy UG, Singh AK, Singh B, Jain N, Singh PK, Singh GP.   +12 more
europepmc   +1 more source

Long‐term culture of skin biopsies: maintenance of fibroblast production and competency of reprogramming

FEBS Open Bio, EarlyView.
Skin biopsies taken from a patient with an ultra‐rare disorder as well as controls were cultured for up to 473 days. The chunks of skin were serially transferred to a new culture plate when confluent with fibroblasts. Different generations of fibroblasts were analyzed for cell and molecular properties, proliferation, and competence for reprogramming to
Sudiksha Rathan‐Kumar, Michael A. Ripperger, Grant M. Westlake, Kevin C. Ess   +3 more
wiley   +1 more source

Diabetes‐induced vascular calcification is associated with low pyrophosphate and its oral supplementation prevents calcification in diabetic mice

FEBS Open Bio, EarlyView.
Induction of diabetes in three different mouse strains uniformly resulted in an increase in TNAP activity and a reduction in pyrophosphate (PPi) in the circulation. Inhibition of TNAP restored plasma PPi. Diabetes‐induced calcification in the media layer of the aorta was detected only in the Abcc6−/− strain, which is predisposed to ectopic ...
Krisztina Fülöp, Eszter Kozák, Natália Tőkési, Lilian Kocsis, Anikó Kelemen, Zsuzsanna Geszti, Adriána Kutás, Mariann Harangi, Ágnes Diószegi, Zsolt Rapi, József Balla, Olivier Le Saux, András Váradi, Viola Pomozi   +13 more
wiley   +1 more source

Correction: Carrying APOL1 G1 allele is associated with cardiovascular complications during COVID-19 in an admixed population. [PDF]

Hum Genomics
Cadore NA, Fam BSO, Giudicelli GC, Kowalski TW, Sbruzzi RC, Castro E Silva MA, Feira MF, de Souza CMB, da Silva DR, Artigalás O, Lemes RB, Rodrigues MR, Nunes K, Pereira AC, Pereira LV, Hünemeier T, Vianna FSL.   +16 more
europepmc   +1 more source

diveRsity: An R package for the estimation and exploration of population genetics parameters and their associated errors

, 2013
K. Keenan, P. McGinnity, T. Cross, W. Crozier, P. Prodöhl   +4 more
semanticscholar   +1 more source