Results 201 to 210 of about 1,352,174 (294)

The effect of long-range linkage disequilibrium on allele-frequency dynamics under stabilizing selection. [PDF]

PLoS Genet
Negm S, Veller C.
europepmc   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Genetic diversity and population structure of pearl millet in the Senegalese germplasm. [PDF]

PLoS One
Ba A, Odong TL, Edema R, Badji A, Diack O, Obua T, Ochwo-Semakula M, Gibson P, Kane NA, Tukamuhabwa P.   +9 more
europepmc   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Human population genetics of the Mediterranean

Annals of Human Biology, 2018
David Comas, Donata Luiselli, Olga Rickards   +2 more
doaj   +1 more source

Population genetics models of apomixis [PDF]

, 1973
Pernès, Jean
core  

Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment

Aging and Cancer, EarlyView.
Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey, Murilo Ramos Rocha, Cheyenne Palm, Vania Wang, Denys Balandin, Ethan Black, Kevin Y. Zhang, Fan Huang, Daniel J. Zabransky, Yash Chhabra, Mareike Peters, Gabriel Ghiaur, Ashani Weeraratna   +12 more
wiley   +1 more source

A Beginner's How-To Guide to Urban Population Genetics and Genomics. [PDF]

Ecol Evol
Carlen EJ, Miles LS, Aviles-Rodriguez K, Booth W.   +3 more
europepmc   +1 more source

Prognostic Impact of European LeukemiaNet Genetic Risk Stratification System in Adult Patients With Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
This study aimed to evaluate the prognostic value of ELN2017 in predicting survival outcomes and to assess the impact of clinical and molecular factors such as age, FLT3 and NPM1 mutations, and allogeneic hematopoietic stem cell transplantation (allo‐HSCT).
Mobina Shrestha, Bishwas Mandal, Vishal Mandal, Asis Shrestha, Amir Babu Shrestha   +4 more
wiley   +1 more source

Without Borders? The Impact of Political Barriers and Land Use on the Animal Health Dynamics and Genetic Structures of Large Game Species in the Carpathian Basin and Surrounding Regions-A Systematic Review. [PDF]

Vet Sci
Bagi Z, Knop R, Tulcan C, Tripon R, Marinaș R, Kusza S.   +5 more
europepmc   +1 more source