Results 91 to 100 of about 3,105,692 (378)

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Genetics and clinical correlation of Dravet syndrome and its mimics – experience of a tertiary center in Taiwan

, 2021
Yi-Hsuan Liu, Yi-Ting Cheng, Meng‐Han Tsai, I‐Jun Chou, Po‐Cheng Hung, Meng‐Ying Hsieh, Yishan Wang, Yun‐Ju Chen, Cheng‐Yen Kuo, Jainn‐Jim Lin, Huei-Shyong Wang, Kuang‐Lin Lin   +11 more
openalex   +1 more source

Liquid Hydroxyurea (Xromi) for Children With Sickle Cell Anemia: A New Solution Compounding Existing Problems

Pediatric Blood &Cancer, EarlyView.
Alexandra Power‐Hays, Charles T. Quinn
wiley   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Genetic modification and genetic determinism.

Philosophy, ethics, and humanities in medicine : PEHM, 2006
In this article we examine four objections to the genetic modification of human beings: the freedom argument, the giftedness argument, the authenticity argument, and the uniqueness argument. We then demonstrate that each of these arguments against genetic modification assumes a strong version of genetic determinism.
Vorhaus Daniel B, Resnik David B
openaire   +3 more sources

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Correction: The Chromatin Remodelling Enzymes SNF2H and SNF2L Position Nucleosomes adjacent to CTCF and Other Transcription Factors.

PLoS Genetics, 2016
[This corrects the article DOI: 10.1371/journal.pgen.1005940.].
PLOS Genetics Staff
doaj   +1 more source

Population genetics in compressible flows

, 2011
We study competition between two biological species advected by a compressible velocity field. Individuals are treated as discrete Lagrangian particles that reproduce or die in a density-dependent fashion.
A. Kolmogorov, B. A. Whitton, C. Gardiner, David R. Nelson, J. F. Crow, M. Kimura, Mogens H. Jensen, N. G. van Kampen, Roberto Benzi, Simone Pigolotti, T. Bohr   +10 more
core   +1 more source

Using fine‐scale spatial genetics of Norway rats to improve control efforts and reduce leptospirosis risk in urban slum environments [PDF]

, 2016
Jonathan Richardson, Mary K. Burak, Christian Hernandez, James M. Shirvell, Carol Mariani, Ticiana S. A. Carvalho‐Pereira, Arsinoê Cristina Pertile, Jesús Alonso Panti–May, Gabriel Pedra, Soledad Serrano, J. E. Taylor, Mayara Carvalho, Gorete Rodrigues, Federico Costa, James E. Childs, Albert I. Ko, Adalgisa Caccone   +16 more
openalex   +1 more source

The anti‐CRISPR protein AcrIE8.1 inhibits the type I‐E CRISPR‐Cas system by directly binding to the Cascade subunit Cas11

FEBS Letters, EarlyView.
In this study, we present the structure of AcrIE8.1, a previously uncharacterized anti‐CRISPR protein that inhibits the type I‐E CRISPR‐Cas system. Through a combination of structural and biochemical analyses, we demonstrate that AcrIE8.1 directly binds to the Cas11 subunit of the Cascade complex to inhibit the CRISPR‐Cas system.
Young Woo Kang, Hyun Ho Park
wiley   +1 more source