Results 101 to 110 of about 2,771,911 (398)

Stochastic tunneling and metastable states during the somatic evolution of cancer

, 2015
Tumors initiate when a population of proliferating cells accumulates a certain number and type of genetic and/or epigenetic alterations. The population dynamics of such sequential acquisition of (epi)genetic alterations has been the topic of much ...
Ashcroft, Peter, Galla, Tobias, Michor, Franziska   +2 more
core   +1 more source

Increasing confidence and changing behaviors in primary care providers engaged in genetic counselling. [PDF]

, 2017
BackgroundScreening and counseling for genetic conditions is an increasingly important part of primary care practice, particularly given the paucity of genetic counselors in the United States.
A Cull, A Schwartz, AO Berg, CA Bellcross, CA Bellcross, CE Franz, CS Skinner, D Kegelaers, DK Sokol, EJ Houwink, EJ Houwink, Erik Lehman, Frank C. Day, FS Collins, Haley McDermott, HJ Baer, J Mancini, JC Carroll, KF Trivers, M Paneque, M Srinivasan, MD Schwartz, Michael J. Green, Michael S. Wilkes, MJ Green, MJ Novak, ML Rinke, NA Mikat-Stevens, PO Ozuah, R Grol, RA Bell, RM Epstein, RM Hoffman, Robert A. Bell, S Appleton, T Pal, TJ Leonarczyk, Tonya L. Fancher, V Rahimzadeh, VA Moyer, W Burke, W Burke, YR Cukier   +42 more
core   +1 more source

Characterization of fungal carbonyl sulfide hydrolase belonging to clade D β‐carbonic anhydrase

FEBS Letters, EarlyView.
Here, we performed a functional analysis of the fungal enzymes belonging to clade D of the β‐class carbonic anhydrase family (β‐D‐CA). The β‐D‐CAs in the basidiomycete Gloeophyllum trabeum and the ascomycete Trichoderma harzianum showed very low activity in the hydration of CO2 but exhibited high activity in the hydrolysis of carbonyl sulfide (COS ...
Ryuka Iizuka, Takahiro Ogawa, Rikako Tsukida, Keiichi Noguchi, David Hibbett, Yoko Katayama, Makoto Yoshida   +6 more
wiley   +1 more source

Correction: RBPJ, the Major Transcriptional Effector of Notch Signaling, Remains Associated with Chromatin throughout Mitosis, Suggesting a Role in Mitotic Bookmarking.

PLoS Genetics, 2016
[This corrects the article DOI: 10.1371/journal.pgen.1004204.].
PLOS Genetics Staff
doaj   +1 more source

Genes Classical And Genes Developmental: The Different Uses Of The Gene In Evolutionary Synthesis [PDF]

, 2000
Dobzhansky (1964) stated that “Nothing in biology makes sense except in the light of evolution,” and the function of the gene is no exception. The use of genes in population genetics and developmental genetics differs significantly.
Gilbert, Scott F.
core   +2 more sources

A histidine‐rich extension of the mitochondrial F0 subunit ATP6 from the ice worm Mesenchytraeus solifugus increases ATP synthase activity in bacteria

FEBS Letters, EarlyView.
The glacier ice worm Mesenchytraeus solifugus survives year‐round at 0 °C. Its ATP6 subunit, which forms a regulatory component of the proton pore in mitochondrial ATP synthase, has a carboxy‐terminal extension not found in any other organism examined to date. Here, we show that fusion of this extension to the homologous AtpB protein in E. coli results
Truman Dunkley, Daniel H. Shain, Eric A. Klein   +2 more
wiley   +1 more source

Stroke Risk Factors, Genetics, and Prevention

Circulation Research, 2017
Stroke is a heterogeneous syndrome, and determining risk factors and treatment depends on the specific pathogenesis of stroke. Risk factors for stroke can be categorized as modifiable and nonmodifiable. Age, sex, and race/ethnicity are nonmodifiable risk
A. Boehme, Charles C. Esenwa, M. Elkind
semanticscholar   +1 more source

Two-Locus Likelihoods under Variable Population Size and Fine-Scale Recombination Rate Estimation

, 2016
Two-locus sampling probabilities have played a central role in devising an efficient composite likelihood method for estimating fine-scale recombination rates.
Chan, Jeffrey, Kamm, John A., Song, Yun S., Spence, Jeffrey P.   +3 more
core   +1 more source

Summaries of plenary, symposia, and oral sessions at the XXII World Congress of Psychiatric Genetics, Copenhagen, Denmark, 12-16 October 2014 [PDF]

, 2016
The XXII World Congress of Psychiatric Genetics, sponsored by the International Society of Psychiatric Genetics, took place in Copenhagen, Denmark, on 12-16 October 2014.
Aas, Monica, Blokland, Gabriëlla A.M., Chawner, Samuel J.R.A., Choi, Shing-Wan, Cormack, Freida K., DeLisi, Lynn, Estrada, Jose, Forsingdal, Annika, Friedrich, Maximilian, Ganesham, Suhas, Hall, Lynsey, Haslinger, Denise, Huckins, Laura, Loken, Erik, Malan-Müller, Stefanie, Martin, Joanna, Misiewicz, Zuzanna, Pagliaroli, Luca, Pardiñas, Antonio F., Pisanu, Claudia, Quadri, Giorgia, Ranlund, Siri, Santoro, Marcos L., Shaw, Alex D., Song, Jie, Tesli, Martin, Tropeano, Maria, van der Voet, Monique, Wolfe, Kate   +28 more
core   +2 more sources

Elucidation of interface interactions between a dehydratase domain and an acyl carrier protein in cremimycin polyketide synthase

FEBS Letters, EarlyView.
In modular polyketide synthases, the dehydratase (DH) domain catalyzes the dehydration reaction of the β‐hydroxyacyl unit attached to the cognate acyl carrier protein (ACP) domain. However, it is unclear how DH interacts with ACP during the reaction. In this study, we identified DH–ACP interface residues, providing the first detailed insights into DH ...
Kaede Kotagiri, Haruka Tachibana, Daisuke Kawasaki, Taichi Chisuga, Toma Kashima, Shinya Fushinobu, Fumitaka Kudo, Tadashi Eguchi, Akimasa Miyanaga   +8 more
wiley   +1 more source