Results 311 to 320 of about 2,983,560 (395)

Integrating molecular genetics with plant breeding to deliver impact. [PDF]

Plant Physiol
Sharma R, Yang CJ, Rossi N, Irving E, Tuffin A, Aliki H, Powell W, Dawson IK.   +7 more
europepmc   +1 more source

Genetics of Platypoecilus maculatus. V. Heterogametic sex-determing mechanism in females of a domesticated stock originally from British Honduras

, 1951
Myron Gordon
openalex   +1 more source

The critical role of DNA damage‐inducible transcript 4 (DDIT4) in stemness character of leukemia cells and leukemia initiation

Molecular Oncology, EarlyView.
Stemness properties, including quiescence, self‐renewal, and chemoresistance, are closely associated with leukemia relapse. Here, we demonstrate that DNA damage‐inducible transcript 4 (DDIT4) is induced in the hypoxic bone marrow niche and is essential for maintaining the stemness of AML1‐ETO9a leukemia cells.
Yishuang Li, Zhijie Cao, Haiyan Xing, Zhenya Xue, Wenbing Liu, Jiayuan Chen, Yihan Mei, Runxia Gu, Hui Wei, Shaowei Qiu, Min Wang, Qing Rao, Jianxiang Wang   +12 more
wiley   +1 more source

View of healthcare professionals on ultra-rapid genome sequencing and its future implementation in clinical practice for critically ill children. [PDF]

Eur J Hum Genet
Caillot C, Javouhey E, Hays S, Gouy E, Monin P, Lesca G, Sanlaville D, Chatron N.   +7 more
europepmc   +1 more source

Unveiling unique protein and phosphorylation signatures in lung adenocarcinomas with and without ALK, EGFR, and KRAS genetic alterations

Molecular Oncology, EarlyView.
Proteomic and phosphoproteomic analyses were performed on lung adenocarcinoma (LUAD) tumors with EGFR, KRAS, or EML4–ALK alterations and wild‐type cases. Distinct protein expression and phosphorylation patterns were identified, especially in EGFR‐mutated tumors. Key altered pathways included vesicle transport and RNA splicing.
Fanni Bugyi, Mirjam Balbisi, Simon Sugár, Lóránd Váncza, Eszter Regős, Ilona Kovalszky, Ibolya Laczó, Tünde Harkó, Gábor Kecskeméti, Zoltán Szabó, Judit Moldvay, László Drahos, Lilla Turiák   +12 more
wiley   +1 more source

Association of Polygenic-Based Breast Cancer Risk Prediction With Patient Management. [PDF]

JCO Precis Oncol
Johansen Taber K, Hughes E, Gutin A, DeHart WB, Becker L, Jasper J, Ratzel S, Miller DC, Chawla D, Morin P, Certa J, Kurian AW.   +11 more
europepmc   +1 more source

Targeting of PTP4A3 overexpression sensitises HGSOC cells towards chemotherapeutic drugs

Molecular Oncology, EarlyView.
In HGSOC with normal KRAS expression, high PTP4A3 expression regulates autophagy activation. Conversely, in HGSOC with high KRAS expression, KRAS dictates autophagy control, and PTP4A3 is not required. When high PTP4A3 expression is inhibited, HGSOC cells are preferentially sensitised towards DNA‐damaging agents.
Ana López‐Garza, David James, Emma Creagh, James T. Murray   +3 more
wiley   +1 more source

Genetics Evaluation Outcomes From an Academic Multidisciplinary Atypical Diabetes Program. [PDF]

J Endocr Soc
Chase CL, Accardo ML, Greve V, Ames EG, Quinonez SC, Scott A, Hipp L, Damon J, Uhlmann WR, Broome DT, Foss-Freitas MC, Akinci B, Neidert AH, Narla G, Oral EA, Lee KN.   +15 more
europepmc   +1 more source

Olaparib synergy screen reveals Exemestane induces replication stress in triple‐negative breast cancer

Molecular Oncology, EarlyView.
Screening 166 FDA‐approved anticancer drugs identifies the aromatase inhibitor Exemestane as a synergistic partner of PARP inhibitor Olaparib in BRCA‐proficient triple‐negative breast cancer. Exemestane induces ROS‐mediated replication stress, enhancing DNA damage and apoptosis alongside Olaparib.
Nur Aininie Yusoh, Liping Su, Suet Lin Chia, Xiaohe Tian, Haslina Ahmad, Martin R. Gill   +5 more
wiley   +1 more source