Results 151 to 160 of about 640,355 (344)

Advances in Cotton Genomics, Genetics and Breeding

Plants
The cotton is an industrial crop of global significance, providing its fibers for the predominant textile material and its seed accumulating abundant oil and protein for other utilizations [...]
Tianxu Zhang, Shuhui Wang, Jinhong Chen, Shuijin Zhu, Qianhao Zhu, Tianlun Zhao   +5 more
doaj   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

Recommendations for reporting of secondary findings in clinical exome and genome sequencing, 2016 update (ACMG SF v2.0): a policy statement of the American College of Medical Genetics and Genomics

Genetics in Medicine, 2016
Sarah S. Kalia, Kathy Adelman, Sherri Bale, Wendy K Chung, Christine M. Eng, James P. Evans, Gail E. Herman, Sophia B. Hufnagel, Teri E. Klein, Bruce R. Korf, Kent D. McKelvey, K. Ormond, C. Richards, C. Vlangos, Michael S. Watson, Christa L. Martin, David T. Miller   +16 more
semanticscholar   +1 more source

Insights into a long life without cancer: The case of the bowhead whale

Molecular Oncology, EarlyView.
Long‐lived, large‐bodied organisms have evolved powerful anticancer mechanisms that preserve cellular and tissue integrity across extended lifespans. A recent study by Firsanov et al. shows that greater genome stability is a key factor underlying the remarkable longevity and cancer resistance of one such species, the bowhead whale.
Inés Paniagua, Johanna A. Joyce
wiley   +1 more source

The HUGO Clinical Genomics & Genomic Medicine Education Survey: clinicians globally need and want genomic medicine training

Human Genomics
Background The Clinical Genomics & Genomic Medicine Education subcommittee of the Human Genome Organization (HUGO) reports on the results of an exploratory genomic medicine survey of healthcare providers (clinicians) in low- and middle-income countries ...
Charles Wray, Edward S. Tobias, Dhavendra Kumar, Qasim Ayub, Ada Hamosh, Iscia Lopes-Cendes, Luz Berenice Lopez Hernandez, Sherifa Ahmed Hamed   +7 more
doaj   +1 more source

Communication between distinct subunit interfaces of the cohesin complex promotes its topological entrapment of DNA. [PDF]

, 2019
Cohesin mediates higher order chromosome structure. Its biological activities require topological entrapment of DNA within a lumen(s) formed by cohesin subunits.
Chatterjee, Fiona, Guacci, Vincent, Koshland, Douglas, Robison, Brett   +3 more
core   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Mainstreaming genetics and genomics: a systematic review of the barriers and facilitators for nurses and physicians in secondary and tertiary care

Genetics in Medicine, 2020
S. White, C. Jacobs, J. Phillips
semanticscholar   +1 more source

Medicago truncatula functional genomics: an invaluable resource for studies on agriculture sustainability [PDF]

, 2012
Legume functional genomics has moved many steps forward in the last two decades thanks to the improvement of genomics technologies and to the efforts of the research community.
Calderini, Ornella, Panara, Francesco, Porceddu, Andrea   +2 more
core  

Molecular cancer prevention: Intercepting disease

Molecular Oncology, EarlyView.
Oncological practice must evolve, from treating established tumours to proactive cancer interception before clinical manifestation. This will require mechanistic insight into tumour initiation, validated biomarkers of early disease development and redesigned clinical trials, enabling cancer interception to become a core pillar of oncology with the ...
Charlotte Grieco, Tej Pandya, Charles Swanton   +2 more
wiley   +1 more source