Results 71 to 80 of about 343,001 (303)
DNA ligase LigE increases bacterial transformation with damaged extracellular DNA
FEBS Letters, EarlyView.The DNA ligase LigE from the naturally competent Gram‐negative bacterium Neisseria gonorrhoaea increases transformation with cut extracellular DNA. This process is ATP‐dependent and relies on the catalytic activity of LigE; it also requires that LigE contains an intact periplasmic localisation sequence, indicating that ligE functions in the periplasm ...
Jolyn Pan +4 more
wiley +1 more source
Journal of Medical Education and Curricular Development, 2019 Background: As pharmacogenomics (PGx), a component of genetics/genomics and precision medicine, gains traction in the clinical setting, education of health care providers and health professions students must be made broadly available to improve ...
David F Kisor, Christopher L Farrell
doaj +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
GENETICS AND GENOMICS IN NURSING PRACTICE: ASSESSING BARRIERS, FACILITATORS, AND TAILORING IMPLEMENTATION STRATEGIES [PDF]
, 2022 The Essential Nursing Competencies and Curricula Guidelines for Genetics and Genomics were published in 2006. These guidelines define the minimal competency in genetics expected of all nurses regardless of role, specialty, or level of education. However,
Guillory, JaAnna
core +1 more source
Advances in faba bean genetics and genomics
Frontiers in Genetics, 2016 Vicia faba L, is a globally important grain legume whose main centres of diversity are the Fertile Crescent and Mediterranean basin. Because of its small number (six) of exceptionally large and easily observed chromosomes it became a model species for ...
Donal Martin O'Sullivan, Deepti Angra
doaj +1 more source
Circulation, 2008 Since its development almost 2 decades ago, gene expression microarray technology has generated excitement and raised expectations for dramatic discoveries of underlying disease mechanisms. The general concept of a gene expression microarray is relatively straightforward. Messenger RNA is extracted from a biospecimen.
openaire +2 more sources
Citizens’ Literacy in Genomics: A Delphi Survey of Multidisciplinary Experts in the Field
, 2022 Introduction: Citizens’ literacy in the field of genomics represents one of the cornerstones of proper implementation of genomics in healthcare services.
Giovanna Elisa Calabrò +2 more
core +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Edible Mushrooms: Genetics, Genomics, and Breeding
HorticulturaeEdible mushrooms deliver valuable food supplies, bioactive metabolites, and critical income streams for human populations [...]
Jie Chen, Mingwen Zhao, Junjie Yan
doaj +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source