Results 81 to 90 of about 640,355 (344)

Integrative Genomics Reveals the Genetics and Evolution of the Honey Bee’s Social Immune System [PDF]

, 2019
Social organisms combat pathogens through individual innate immune responses or through social immunity—behaviors among individuals that limit pathogen transmission within groups.
Currie, Rob, Desai, Suresh, Foster, Leonard, Guarna, Maria Marta, Harpur, Brock, Higo, Heather, Hoover, Shelley, Huxter, Elizabeth, Ibrahim, Abdullah, Melathopoulos, Andony, Moon, Kyung-Mee, Pernal, Stephen, Zayed, Amro   +12 more
core   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Genetic Error and Genome Design

Cold Spring Harbor Symposia on Quantitative Biology, 1986
Abstract The level of noise in the copier systems of the most ancient genes was probably seven to eight orders of magnitude higher than that found in the high-fidelity copiers of contemporary cells. The design of the genetic machinery in all forms of life has been fundamentally shaped by the need to minimize the harmful effects of high error rates.
openaire   +2 more sources

Gac two-component system in Pseudomonas syringae pv. tabaci is required for virulence but not for hypersensitive reaction [PDF]

, 2008
Pseudomonas syringae pv. tabaci 6605 causes wildfire disease on host tobacco plants. To investigate the regulatory mechanism of the expression of virulence, Gac two-Component system-defective mutants, Delta gacA and Delta gacS, and a double mutant, Delta
A Bultreys, A Chatterjee, A Schaefer, A Stintzi, B Quinones, B Quinones, C Fuqua, DK Willis, EO King, F Taguchi, F Taguchi, Fumiko Taguchi, J Yu, JW Costerton, Kazuhiro Toyoda, KH McClean, LM Keith, M Castaneda, M Elasri, M Marutani, MD Parkins, Md. Mijan Hossain, MF Alexeyev, Mizuri Marutani, NT Keen, PD Shaw, S Heeb, SL Lopez-Garcia, SM Kirov, ST Chancey, T Kitten, TG Kinscherf, TM Barta, Tomonori Shiraishi, WF Fett, Y Ishiga, Yoshishige Inagaki, Yujiro Ogawa, Yuki Ichinose   +38 more
core   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Genetics and Genomics [PDF]

JAMA, 2007
The October 15, 1997, issue of JAMA1 was devoted to genetics and featured articles on genomic screening in late-onset familial Alzheimer disease, BRCA1 sequence analysis, hereditary prostate cancer 1 locus, chromosome 19 single locus, and multilocus haplotype associations with multiple sclerosis, cancer incidence after retinoblastoma, prenatal genetic ...
Catherine D, DeAngelis, Phil B, Fontanarosa, Mary-Claire, King, Boris, Pasche   +3 more
openaire   +2 more sources

From genetical genomics to systems genetics: potential applications in quantitative genomics and animal breeding [PDF]

, 2018
This article reviews methods of integration of transcriptomics (and equally proteomics and metabolomics), genetics, and genomics in the form of systems genetics into existing genome analyses and their potential use in animal breeding and quantitative ...
Janss, Luc, Kadarmideen, Haja, von Rohr, Peter   +2 more
core  

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Facilitating faculty competency to integrate genomics into nursing curriculum within a private US University

Nursing: Research and Reviews, 2018
Lisa M Bashore, Glenda Daniels, Lori Borchers, Lynette L Howington, Dennis J Cheek Harris College of Nursing and Health Sciences, Texas Christian University, Fort Worth, TX, USA Background: This quasi-experimental study explored full-time nurse faculty ...
Bashore LM, Daniels G, Borchers L, Howington LL, Cheek DJ   +4 more
doaj