Results 141 to 150 of about 1,217,828 (289)

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira, Anna Skwarska, Karolina Chwialkowska, Agnieszka Ostrowska, Gabriela Sokolowska, Anna Zeller, Anna Erol, Andrzej Eljaszewicz, Bartosz Hanczaruk, Anna Michalska‐Falkowska, Agnieszka Tarasik, Joanna Reszec‐Gielazyn, Pawel Knapp, Marcin Moniuszko, Adam Kretowski   +14 more
wiley   +1 more source

Clinical genetics of melanoma

Hereditary Cancer in Clinical Practice, 2011
Debniak T
doaj   +1 more source

Caloric restriction modifies small RNA profiles and engages age-related molecular pathways in the CALERIE trial

iScience
Summary: Caloric restriction (CR) extends lifespan and enhances healthspan across species. In humans, the CALERIE Phase 2 trial demonstrated that CR improves inflammation, cardiometabolic health, and molecular aging.
Melissa C. Orenduff, Kim M. Huffman, Daniel W. Belsky, Carl F. Pieper, William E. Kraus, Virginia B. Kraus   +5 more
doaj   +1 more source

Interplay of host genetics and gut microbiota underlying the onset and clinical presentation of inflammatory bowel disease [PDF]

, 2016
Floris Imhann, Arnau Vich Vila, Marc Jan Bonder, Jingyuan Fu, Dirk Gevers, Marijn C. Visschedijk, Lieke M. Spekhorst, Rudi Alberts, Lude Franke, Hendrik M. van Dullemen, Rinze W. F. ter Steege, Curtis Huttenhower, Gerard Dijkstra, Ramnik J. Xavier, Eleonora A. Festen, Cisca Wijmenga, Alexandra Zhernakova, Rinse K. Weersma   +17 more
openalex   +1 more source

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

Molecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath, Irene A. George, Srikanth S. Manda, Prasanth Ariyannur, Ekta R. Dhawale, Raja Sekhar Kommu, Rajan Datar, Darshana Patil, Vinita Trivedi, Manisha Singh, Kumar Prabhash, Sewanti Limaye, Richa Chauhan, Prashant Kumar   +13 more
wiley   +1 more source

Atlas of the clinical genetics of human dilated cardiomyopathy

, 2014
Jan Haas, Karen Frese, Barbara Peil, Wanda Kloos, Andreas Keller, Rouven Nietsch, Feng Zhu, Sabine Müller, Elham Kayvanpour, Britta Vogel, Farbod Sedaghat‐Hamedani, Wei-Keat Lim, Xiaohong Zhao, Dmitriy Fradkin, Doreen Köhler, Simon Fischer, Jennifer Franke, Sabine Marquart, Ioana Barb, Daniel Tian Li, Ali Amr, Philipp Ehlermann, Derliz Mereles, Tanja Weis, Sarah Hassel, Andreas Kremer, Vanessa King, Emil Wirsz, Richard Isnard, Michel Komajda, Alessandra Serio, Maurizia Grasso, Petros Syrris, Eleanor Wicks, Vincent Plagnol, Luís R. Lopes, Tenna Gadgaard, Hans Eiskjær, Mads Emil Jørgensen, Diego García-Giustiniani, Martín Ortiz-Genga, María G. Crespo‐Leiro, Rondal H. Lekanne Dit Deprez, Imke Christiaans, Ingrid A van Rijsingen, Arthur A. Wilde, Anders Waldenström, Martino Bolognesi, Riccardo Bellazzi, Stellan Mörner, Justo Lorenzo Bermejo, Lorenzo Monserrat, Eric Villard, Jens Mogensen, Yigal M. Pinto, Philippe Charron, Perry Elliott, Eloisa Arbustini, Hugo A. Katus, Benjamin Meder   +59 more
openalex   +2 more sources

Molecular genetics of solid tumours: translating research into clinical practice. What we could do now: breast cancer [PDF]

, 2001
Sunil R. Lakhani
openalex   +1 more source

Sebaceous Carcinoma Epidemiology and Genetics: Emerging Concepts and Clinical Implications for Screening, Prevention, and Treatment [PDF]

, 2020
Michael R. Sargen, Gabriel J. Starrett, Eric A. Engels, Elizabeth K. Cahoon, Margaret A. Tucker, Alisa M. Goldstein   +5 more
openalex   +1 more source

YAP1::TFE3 mediates endothelial‐to‐mesenchymal plasticity in epithelioid hemangioendothelioma

Molecular Oncology, EarlyView.
The YAP1::TFE3 fusion protein drives endothelial‐to‐mesenchymal transition (EndMT) plasticity, resulting in the loss of endothelial characteristics and gain of mesenchymal‐like properties, including resistance to anoikis, increased migratory capacity, and loss of contact growth inhibition in endothelial cells.
Ant Murphy, Samuel Hartzler, Paula A. Vargas Carranza, Shyaman Jayasundara, Madison E. Yates, Nimod D. Janson, Bozhi Liu, Annaleigh Benton, Majid Kazemian, Jason A. Hanna   +9 more
wiley   +1 more source

Clinical Tumor Sequencing: An Incidental Casualty of the American College of Medical Genetics and Genomics Recommendations for Reporting of Incidental Findings

, 2014
D. Williams Parsons, Angshumoy Roy, Sharon E. Plon, Sukla Roychowdhury, Arul M. Chinnaiyan   +4 more
openalex   +1 more source