Results 151 to 160 of about 688,262 (355)

Pediatric critical illness endotypes reveal distinct outcomes and immune pathways shared across cause of illness

iScience
Summary: Characterization of shared patterns of immune responses in critical illnesses, known as “endotypes,” may have therapeutic significance. Using unsupervised k-means clustering of genome-wide gene expression profiling, we derived, validated, and ...
Michael J. Carter, Joshua Hageman, Yael Feinstein, Jethro Herberg, Dominic Habgood-Coote, Victoria Wright, Samuel Nichols, Nazima Pathan, Naomi Edmonds, Philip D. Cowie, Katie Burnham, Alexander Mentzer, Julian Knight, Michael Levin, Myrsini Kaforou, Simon Nadel, Mark J. Peters, Padmanabhan Ramnarayan   +17 more
doaj   +1 more source

Clinical genetics

, 2000
http://dx.doi.org/10.1136/bmj.287.6398 ...
Burn, John
core  

Identification and prioritization of quality indicators in clinical genetics: An international survey

, 2009
The range and demand for clinical genetic services will continue to grow, and now is an ideal time to assess current service quality. Based on the previous work of quality professional organizations such as the Institute of Medicine (IOM) and The Joint ...
Zellerino, BC, Williams, MS, Milligan, SA, Brooks, R, Gray, Jonathon   +4 more
core   +1 more source

Perspective of clinical genetics.

Journal of Nippon Medical School, 1999
Watanabe, Atushi, Migita, Makoto, Watanabe, Yuko, Shimada, Takashi   +3 more
openaire   +3 more sources

Are You AI's Favorite? EU Legal Implications of Biased AI Systems in Clinical Genetics and Genomics

, 2021
Anastasiya Kiseleva, Paul Quinn
openalex   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

The role of genetics and genomics in clinical psychiatry

, 2018
The enormous successes in the genetics and genomics of many diseases have provided the basis for the advancement of precision medicine. Thus, the detection of genetic variants associated with neuropsychiatric disorders, as well as treatment outcome, has ...
Hoehe, Margret R, Morris-Rosendahl, Deborah J   +1 more
core   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source