Results 81 to 90 of about 10,016,032 (374)

Widening the spectrum of players affected by genetic changes in Wilms tumor relapse

iScience
Summary: Few studies investigated the genetics of relapsed Wilms tumor (WT), suggesting the SIX1 gene, the microRNA processing genes, and the MYCN network as possibly involved in a relevant percentage of relapses. We investigated 28 relapsing WT patients
Sara Ciceri, Alessia Bertolotti, Annalisa Serra, Giovanna Gattuso, Luna Boschetti, Maria Capasso, Cecilia Cecchi, Stefania Sorrentino, Paola Quarello, Chiara Maura Ciniselli, Paolo Verderio, Loris De Cecco, Giacomo Manenti, Francesca Diomedi Camassei, Paola Collini, Filippo Spreafico, Daniela Perotti   +16 more
doaj   +1 more source

IL6/IL6R genetic diversity and plasma IL6 levels in bipolar disorder: An Indo-French study

Heliyon, 2019
Reports of association of genetic variants of IL6 and its receptor (IL6R) with psychiatric disorders are inconsistent, and there are few population-based studies thus far in bipolar disorder (BD).
Aparna Sundaresh, José Oliveira, Raj Kumar Chinnadurai, Ravi Philip Rajkumar, Lylia Hani, Rajagopal Krishnamoorthy, Marion Leboyer, Vir Singh Negi, Ryad Tamouza   +8 more
doaj   +1 more source

Current State of Compulsory Basic and Clinical Courses in Genetics for Medical Students at Medical Faculties in Balkan Countries With Slavic Languages

Frontiers in Genetics, 2022
Introduction: In this study we aimed to perform the first research on the current state of compulsory basic and clinical courses in genetics for medical students offered at medical faculties in six Balkan countries with Slavic languages (Bosnia and ...
Nina Pereza, Nina Pereza, Rifet Terzić, Dijana Plaseska-Karanfilska, Olivera Miljanović, Olivera Miljanović, Ivana Novaković, Željka Poslon, Željka Poslon, Saša Ostojić, Saša Ostojić, Borut Peterlin   +11 more
doaj   +1 more source

Multi-trait analysis characterizes the genetics of thyroid function and identifies causal associations with clinical implications

Nature Communications
Thyroid dysfunction is involved in many diseases. Here, the authors provide insights into the genetics and biological pathways influencing important thyroid function parameters, showing potential causal effects on many clinical outcomes.
R. Sterenborg, I. Steinbrenner, Yong Li, Melissa Bujnis, Tatsuhiko Naito, E. Marouli, T. Galesloot, Oladapo Babajide, L. Andreasen, A. Astrup, B. Åsvold, S. Bandinelli, M. Beekman, J. Beilby, J. Bork-Jensen, Thibaud S. Boutin, J. Brody, Suzanne J Brown, B. Brumpton, Purdey J Campbell, A. Cappola, Graziano Ceresini, L. Chaker, D. Chasman, M. P. Concas, Rodrigo Coutinho de Almeida, Simone M Cross, Francesco Cucca, I. Deary, A. D. Kjaergaard, J. E. Echouffo Tcheugui, Christina Ellervik, J. Eriksson, L. Ferrucci, Jan Freudenberg, C. Fuchsberger, C. Gieger, Franco Giulianini, Martin Gögele, Sarah E. Graham, N. Grarup, I. Gunjača, T. Hansen, Barbara N. Harding, Sarah E. Harris, S. Haunsø, C. Hayward, Jennie Hui, Till Ittermann, J. Jukema, E. Kajantie, J. Kim Kanters, L. Kårhus, L. Kiemeney, M. Kloppenburg, Brigitte Kühnel, J. Lahti, C.J.M. Langenberg, B. Lapauw, Graham P. Leese, Shuo Li, D. Liewald, A. Linneberg, Jesus V. T. Lominchar, J. Luan, Nicholas G. Martin, A. Matana, Marcel E Meima, T. Meitinger, I. Meulenbelt, Braxton D. Mitchell, L. Møllehave, Samia Mora, S. Naitza, Matthias Nauck, R. Netea-Maier, R. Noordam, Casia Nursyifa, Yukinori Okada, Stefano Onano, A. Papadopoulou, Colin N. A. Palmer, C. Pattaro, Oluf Pedersen, A. Peters, Maik Pietzner, O. Polašek, P. Pramstaller, B. Psaty, A. Punda, Debashree Ray, P. Redmond, J. Richards, Paul M Ridker, Tom C. Russ, Kathleen A. Ryan, M. S. Olesen, U. Schultheiss, Elizabeth Selvin, M. Siddiqui, C. Sidore, P. Slagboom, T. I. Sørensen, E. Soto-Pedre, Timothy D Spector, B. Spedicati, Sundararajan Srinivasan, J. Starr, D. Stott, Toshiko Tanaka, V. Torlak, S. Trompet, Johanna Tuhkanen, A. Uitterlinden, Erik Ben Akker, T. Eynde, M. Klauw, D. Heemst, C. Verroken, W. Visser, D. Vojinovic, H. Völzke, M. Waldenberger, John P Walsh, N. Wareham, Stefan Weiss, C. Willer, Scott G Wilson, B. Wolffenbuttel, H. Wouters, M. J. Wright, Qiong Yang, T. Zemunik, Wei Zhou, G. Zhu, Sebastian Zöllner, Johannes W Smit, Robin P Peeters, A. Köttgen, A. Teumer, M. Medici, Ghs DiscovEHR, Regeneron Genetics Center   +142 more
semanticscholar   +1 more source

Origin of life: β‐sheet amyloid conformers as the primordial functional polymers on the early Earth and their role in the emergence of complex dynamic networks

FEBS Letters, EarlyView.
The amyloid world hypothesis of the origin‐of‐life posits that the first functional polymers on the early Earth were structurally stable cross‐β‐sheet‐based peptide amyloids capable of Darwinian‐like evolution. Peptide amyloids display self‐replication and information transfer, as well as catalytic, adaptive, and evolutive properties.
Carl Peter J. Maury
wiley   +1 more source

Estimating the number of diseases – the concept of rare, ultra-rare, and hyper-rare

iScience, 2022
Summary: At the dawn of the personalized medicine era, the number of rare diseases has been estimated at 10,000. By considering the influence of environmental factors together with genetic variations and our improved diagnostic capabilities, an ...
C. I. Edvard Smith, Peter Bergman, Daniel W. Hagey   +2 more
doaj   +1 more source

The epithelial barrier theory proposes a comprehensive explanation for the origins of allergic and other chronic noncommunicable diseases

FEBS Letters, EarlyView.
Exposure to common noxious agents (1), including allergens, pollutants, and micro‐nanoplastics, can cause epithelial barrier damage (2) in our body's protective linings. This may trigger an immune response to our microbiome (3). The epithelial barrier theory explains how this process can lead to chronic noncommunicable diseases (4) affecting organs ...
Can Zeyneloglu, Huseyn Babayev, Ismail Ogulur, Sena Ardicli, Yagiz Pat, Duygu Yazici, Bingjie Zhao, Lihong Chang, Xiaoqing Liu, Paolo D'Avino, Manru Li, Ceren Biçer, Fatma Hacer Kurtoğlu Babayev, Raja Dhir, Kari C. Nadeau, Marie‐Charlotte Brüggen, Mubeccel Akdis, Cezmi A. Akdis   +17 more
wiley   +1 more source

Ethical Issues in Contemporary Clinical Genetics

Mayo Clinic Proceedings: Innovations, Quality & Outcomes, 2018
As genetic sequencing capabilities become more powerful and costs decline, the reach of genomics is expanding beyond research laboratories to the wards, outpatient clinics, and, with the marketing of direct-to-consumer testing services, patients’ homes ...
Genna Braverman, MD, Zachary E. Shapiro, JD, MSc, Jonathan A. Bernstein, MD, PhD   +2 more
doaj   +1 more source

METHODS OF MODERN GENETICS

Байкальский медицинский журнал, 2023
Modern genetics uses a number of methods that are its tools in understanding the essence of human hereditary pathology. Genetic methods are usually used together.
Elena Anatolyevna Tkachuk, Igor Zhanovich Seminsky   +1 more
doaj   +1 more source

Goodbye flat lymphoma biology

FEBS Letters, EarlyView.
Three‐dimensional (3D) biological systems have become key tools in lymphoma research, offering reliable in vitro and ex vivo platforms to explore pathogenesis and support precision medicine. This review highlights current 3D non‐Hodgkin lymphoma models, detailing their features, advantages, and limitations, and provides a broad perspective on future ...
Carla Faria, Cèlia Dobaño‐López, Patricia Pérez‐Galán, Christine Bezombes   +3 more
wiley   +1 more source