Results 101 to 110 of about 688,262 (355)

19. MALE BREAST CANCER: AETIOLOGY, GENETICS AND CLINICAL MANAGEMENT [PDF]

, 2002
MD Tischkowitz, S V Hodgson, Fentiman Is
openalex   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Correction to: Physician Knowledge of Human Genetic Variation, Beliefs About Race and Genetics, and Use of Race in Clinical Decision-making [PDF]

, 2019
Sherrill L. Sellers, Brooke A. Cunningham, Vence L. Bonham   +2 more
openalex   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Clinical studies on submicroscopic subtelomeric rearrangements: a checklist.

, 2001
BACKGROUND: Submicroscopic subtelomeric chromosome defects have been found in 7.4% of children with moderate to severe mental retardation and in 0.5% of children with mild retardation. Effective clinical preselection is essential because of the technical
Malcolm, S, Super, M, Knight, S.J., White, S.M., Splitt, M, Flint, J, McKeown, C., Malcolm, S., de Vries, BB, Hurst, JA, Niermeijer, MF, Trainer, A, Quarrell, O.W., White, SM, Knight, Samantha, Super, M., Quarrell, O, de Vries, B B A, Winter, R, Trainer, AH, Winter, RM, Young, ID, Young, I, Regan, R, Trainer, A.H., Knight, SJ, Vries, L.B.A. de, Young, I.D., Flint, Jonathan, Niermeijer, Martinus, Flint, J., Winter, R.M., Niermeijer, M, Homfray, T, Hurst, J, Quarrell, OW, Vries, LBA, Homfray, T., Splitt, M., White, S, Hurst, J.A., Knight, SJL, Quarrell, OWJ, Knight, S, McKeown, C, Regan, R., Niermeijer, M.F.   +46 more
core   +1 more source

ABC of clinical genetics. Prenatal diagnosis. [PDF]

, 1989
Helen Kingston
openalex   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Blood cell traits and venous thromboembolism in East Asians: Observational and genetic evidence

iScience
Summary: Previous studies have indicated that various blood cell traits are associated with a higher risk of venous thromboembolism (VTE). However, the causal relationship remains uncertain.
Haobo Li, Mengjie Duo, Zhu Zhang, Haoyi Weng, Dong Liu, Yu Zhang, Linfeng Xi, Bingzhang Zou, Huiwen Li, Gang Chen, Xianbo Zuo, Kaoru Ito, Wanmu Xie, Peiran Yang, Chen Wang, Zhenguo Zhai   +15 more
doaj   +1 more source

Digital innovation for cancer risk assessment allows large-scale service redevelopment of regional cancer genetics service delivery. [PDF]

Family-history assessment can identify individuals above population-risk for cancer to enable targeted Screening, Prevention and Early Detection (SPED).
Elms, M, Snape, K., Forman, A., Hanson, H., Youngs, A, Short, J., Youngs, A., Kohut, K., Snape, K, Hlaing, M. T., Forman, A, Short, J, Elms, M., Hlaing, MT, Kohut, K, Hanson, H   +15 more
core   +1 more source