Results 81 to 90 of about 6,322,056 (300)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Base editing and nanoparticle transfection of airway cell types essential for treatment of cystic fibrosis

JCI Insight
Cystic fibrosis (CF) is a life-limiting genetic disorder caused by deleterious variants in the CFTR gene that results in altered mucus impairing the airway epithelia.
Erin W. Kavanagh, Anya T. Joynt, Audrey R. Pion, Alice C. Eastman, Alianna I. Parr, Katherine L. Starego, Manav Jain, Sydney R. Shannon, Edwin J. Yoo, Gregory A. Newby, Stephany Y. Tzeng, Neeraj Sharma, Jordan J. Green, Garry R. Cutting   +13 more
doaj   +1 more source

Identifying knowledge deficiencies in genetics education among medical students and interns in Saudi Arabia- A cross-sectional study

BMC Medical Education
Background Understanding genetics is crucial for medical students, particularly in Saudi Arabia, where genetic disorders are prevalent owing to high rates of consanguineous marriages.
Abeer F. Zakariyah, Sadin A. Alamri, Manal M. Alzahrani, Aseel A. Alamri, Muhammad A. Khan, Mehenaz A. Hanbazazh   +5 more
doaj   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

The challenges and opportunities of offering and integrating training in clinical molecular genetics and clinical cytogenetics: A survey of LGG Fellowship Program Directors [PDF]

Purpose: The specialty of Laboratory Genetics and Genomics (LGG) was created in 2017 in an effort to reflect the increasing convergence in technologies and approaches between clinical molecular genetics and clinical cytogenetics.
Elena A. Repnikova, Vance, Gail, Yang Cao, Del Gaudio, Daniela, Luo, Minjie, Booker, Jessica, Shao, Lina, Teresa A. Smolarek, Deignan, Joshua L., Williams, Eli, Repnikova, Elena, Jessica K. Booker, Repnikova, Elena A., Vnencak-Jones, Cindy L, Li, Shibo, Rizwan C. Naeem, Leung, Marco L., Van Ziffle, Jessica, Hufnagel, Robert B, Gail H. Vance, Vimla Aggarwal, Deak, Kristen L., Pollard, Laura M, Naeem, Rizwan C, Bellissimo, Daniel B, Williams, Eli S, Deak, Kristen, Hufnagel, Robert B., Smolarek, Teresa, Hufnagel, Robert, Shaw, Brandon, Minjie Luo, Hoppman, Nicole L, Cindy L. Vnencak-Jones, Hoppman, Nicole, Daniela Del Gaudio, Cao, Yang, Liu, Pengfei, Stephen R. Moore, Moore, Stephen R., Leung, Marco L, Funke, Birgit, Colleen Jackson-Cook, Vanessa Horner, Mason-Suares, Heather, Moore, Stephen, Shaw, Brandon M, Shibo Li, Kristy R. Crooks, Naeem, Rizwan, Mao, Minjie Luo Rong, Lina Shao, Mikhail, Fady, Vance, Gail H., Vnencak-Jones, Cindy, Pollard, Laura, Heather Mason-Suares, Bale, Allen E., Bellissimo, Daniel B., Kristen L. Deak, Laura M. Pollard, Birgit Funke, Bellissimo, Daniel, Fady M. Mikhail, Elizabeth Spiteri, Daniel B. Bellissimo, Rong Mao, Spiteri, Elizabeth, Koduru, Prasad, Deignan, Joshua, Brandon M. Shaw, Shaw, Brandon M., Eli S. Williams, Repnikova, Elena A, Bale, Allen, Vnencak-Jones, Cindy L., Allen E. Bale, Vance, Gail H, Leung, Marco, Prasad Koduru, Booker, Jessica K, Jessica Van Ziffle, Crooks, Kristy R., Pengfei Liu, Crooks, Kristy R, Marco L. Leung, Jackson-Cook, Colleen, Mikhail, Fady M., Bale, Allen E, Robert B. Hufnagel, Aggarwal, Vimla, Joshua L. Deignan, Mikhail, Fady M, Deak, Kristen L, Nicole L. Hoppman, Smolarek, Teresa A, Booker, Jessica K., Moore, Stephen R, Deignan, Joshua L, Pollard, Laura M., Williams, Eli S., Crooks, Kristy, Smolarek, Teresa A., Shashirekha Shetty, Hoppman, Nicole L., Shetty, Shashirekha, Horner, Vanessa, Naeem, Rizwan C., Mao, Rong   +108 more
core   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Tell me once, tell me soon: parents’ preferences for clinical genetics services for congenital heart disease [PDF]

, 2018
© 2018, American College of Medical Genetics and Genomics. Purpose: As the molecular basis of congenital heart disease (CHD) comes into sharper focus, cardiac genetics services are likely to play an increasingly important role.
Viney, R, Kasparian, NA, Gary F. Sholler, Richard De Abreu Lourenco, Sholler, GF, Edwin P.E. Kirk, Winlaw, DS, De Abreu Lourenco, R, David S. Winlaw, Rosalie Viney, Kirk, EPE, Nadine A. Kasparian   +11 more
core   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source