Results 1 to 10 of about 40,187 (197)

Depression patient-derived cortical neurons reveal potential biomarkers for antidepressant response [PDF]

European Psychiatry, 2021
Introduction Major depressive disorder is highly prevalent worldwide and has been affecting an increasing number of people each year. Current first line antidepressants show merely 37% remission, and physicians are forced to use a trial-and-error ...
Y. Avior, S. Ron, D. Kroitorou, E. Nitzan, B. Corneo, D. Laifenfeld, T. Cohen Solal   +6 more
doaj   +2 more sources

Acceleration of CRISPR/Cas9-Mediated Editing at Multiple Sites in the Saccharomyces cerevisiae Genome [PDF]

Methods and Protocols, 2023
The application of the CRISPR/Cas9-based genome editing technique to the yeast Saccharomyces cerevisiae has made it possible to simultaneously modify several sites, particularly to integrate several expression cassettes. The existing methods provide high
Alexey D. Karpukhin, Fanis A. Sabirzyanov, Vsevolod A. Serebrianyi   +2 more
doaj   +2 more sources

Patient iPSC-derived neurons reveal mechanisms underlying antidepressant response: a potential diagnostic tool [PDF]

European Psychiatry, 2023
Introduction Depression is a leading cause of disability worldwide despite dozens of approved antidepressants. There are currently no clear guidelines to assist the physician in their choice of drug, with existing tools limited to pharmacogenetics that ...
S. Shohat Koren, D. Kroitorou, C. Albeldas, A. Kugel, N. Askari, T. Cohen Solal, D. Laifenfeld   +6 more
doaj   +2 more sources

Revealing a New Family of D-2-Hydroxyglutarate Dehydrogenases in Escherichia coli and Pantoea ananatis Encoded by ydiJ

Microorganisms, 2022
In E. coli and P. ananatis, L-serine biosynthesis is initiated by the action of D-3-phosphoglycerate dehydrogenase (SerA), which converts D-3-phosphoglycerate into 3-phosphohydroxypyruvate.
Victor V. Samsonov, Anna A. Kuznetsova, Julia G. Rostova, Svetlana A. Samsonova, Mikhail K. Ziyatdinov, Michael Y. Kiriukhin   +5 more
doaj   +1 more source

The Escherichia coli Amino Acid Uptake Protein CycA: Regulation of Its Synthesis and Practical Application in l-Isoleucine Production

Microorganisms, 2022
Amino acid transport systems perform important physiological functions; their role should certainly be considered in microbial production of amino acids.
Christine Hook, Natalya Eremina, Petr Zaytsev, Daria Varlamova, Nataliya Stoynova   +4 more
doaj   +1 more source

Engineering of Escherichia coli Glyceraldehyde-3-Phosphate Dehydrogenase with Dual NAD⁺/NADP⁺ Cofactor Specificity for Improving Amino Acid Production

Microorganisms, 2022
Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is a key enzyme in the central metabolism of microbial cells. GAPDHs differ in cofactor specificity and use NAD+, NADP+, or both cofactors, reducing them to NADH and NADPH, respectively.
Ekaterina A. Slivinskaya, Natalia S. Plekhanova, Irina B. Altman, Tatiana A. Yampolskaya   +3 more
doaj   +1 more source

H⁺-Translocating Membrane-Bound Pyrophosphatase from Rhodospirillum rubrum Fuels Escherichia coli Cells via an Alternative Pathway for Energy Generation

Microorganisms, 2023
Inorganic pyrophosphatases (PPases) catalyze an essential reaction, namely, the hydrolysis of PPi, which is formed in large quantities as a side product of numerous cellular reactions.
Evgeniya A. Malykh, Liubov I. Golubeva, Ekaterina S. Kovaleva, Mikhail S. Shupletsov, Elena V. Rodina, Sergey V. Mashko, Nataliya V. Stoynova   +6 more
doaj   +1 more source

Comparative Analysis of Catabolic and Anabolic Dehydroshikimate Dehydratases for 3,4-DHBA Production in Escherichia coli

Microorganisms, 2022
The production of 3,4-dihydroxybenzoic acid (3,4-DHBA or protocatechuate) is a relevant task owing to 3,4-DHBA’s pharmaceutical properties and its use as a precursor for subsequent synthesis of high value-added chemicals.
Ekaterina A. Shmonova, Ekaterina A. Savrasova, Elizaveta N. Fedorova, Vera G. Doroshenko   +3 more
doaj   +1 more source

PROSES IMPLEMENTASI BIOINFORMATIKA PADA DIGITALISASI DATA GENETIKA MANUSIA

Simetris: Jurnal Teknik Mesin, Elektro dan Ilmu Komputer, 2023
Perkembangan ilmu biologi menjadi pesat khususnya genetika yang  mengakibatkan lonjakan berbagai eksperimen data genetika manusia sebagai pembawa informasi genetik untuk analisis pewarisan sifat dan duplikasi, serta untuk kegiatan forensik.
Herman Herman, Sunardi Sunardi, Tri Stiyo Famuji   +2 more
doaj   +1 more source

The Application of UTY and SRY Molecular Markers for Determination of Unknown Sex Samples in Bali Cattle

Jurnal Ilmu Dasar, 2020
An investigation involving large number of animals is often resulting incomplete or in accurate information such as animal parentage, or misidentify on sex due to unlabeled sex samples.
Indriawati Indriawati, Slamet Diah Volkandari, Endang Tri Margawati   +2 more
doaj   +1 more source