Results 161 to 170 of about 25,462 (209)

Cardiovascular Effects of the Phytoestrogen Genistein

Current Medicinal Chemistry-Cardiovascular & Hematological Agents, 2004
Phytoestrogenic molecules have received a great deal of attention over the last few years because of their potentially preventive roles against a few of today's most prevalent chronic diseases, namely cardiovascular diseases, osteoporosis and hormone related cancers.
ALTAVILLA, Domenica, CRISAFULLI A, MARINI, Herbert Ryan, ESPOSITO M, D'ANNA, Rosario, CORRADO, Francesco, BITTO, ALESSANDRA, SQUADRITO, Francesco   +7 more
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Determination of plasma genistein fatty acid esters following administration of genistein or genistein 4′7-O-dioleate in monkeys

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2005
Soy-derived isoflavone phytoestrogens, such as genistein (4',5,7-trihydroxyisoflavone), have been shown to protect low-density lipoprotein from oxidation. In addition, human plasma was previously shown to be capable of converting genistein into lipophilic fatty acid esters that accumulate in lipoproteins in vitro.
Maija, Badeau, Matti J, Tikkanen, Susan E, Appt, Herman, Adlercreutz, Thomas B, Clarkson, Antti, Hoikkala, Kristiina, Wähälä, Tomi S, Mikkola   +7 more
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Genistein as an anti-inflammatory agent

Inflammation Research, 2003
The aim of this study was to investigate the impact of the isoflavone genistein on in vivo cell-mediated responses. In addition, we wanted to study the influence of genistein on collagen induced arthritis (CIA) in mice.Delayed type hypersensitivity reaction (DTH) to oxazolone and the inflammatory response to olive oil were measured in mice treated with
M, Verdrengh, I M, Jonsson, R, Holmdahl, A, Tarkowski   +3 more
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Reactions of Genistein with Alkylperoxyl Radicals

Chemical Research in Toxicology, 2000
Antioxidant actions of the soy isoflavone genistein are believed to contribute to its overall chemopreventive activity. However, the mechanisms of its antioxidant reactions remain unknown. The objective of this study was to characterize the reaction products of genistein (5,7,4'-trihydroxyisoflavone) with peroxyl radicals generated by thermolysis of 2 ...
A, Arora, S, Valcic, S, Cornejo, M G, Nair, B N, Timmermann, D C, Liebler   +5 more
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Direct action of genistein on CFTR

Pfl�gers Archiv European Journal of Physiology, 1997
Human cystic fibrosis transmembrane conductance regulator (CFTR) chloride channels were expressed in oocytes from Xenopus laevis after injection of CFTR cRNA and studied with the two-electrode voltage-clamp and the giant patch techniques. The tyrosine kinase inhibitor genistein alone activated a small chloride current in whole oocytes expressing CFTR ...
Weinreich, F., Wood, P., Riordan, J., Nagel, G.   +3 more
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PLASMA PHARMACOKINETICS OF GENISTEIN IN MICE

International Journal of Oncology, 1995
Genistein (GEN) has recently generated considerable interest as a potential agent for the prevention and treatment of cancer. The present investigation was undertaken to determine if the concentrations of drug shown to inhibit the growth of human tumor cell lines by 50% in vitro (IC50=2-27 mu g/ml) can be achieved and sustained systemically in mice. We
J, Supko, L, Malspeis
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Genetic toxicity studies with genistein

Food and Chemical Toxicology, 2006
Genistein is a phytoestrogen that occurs naturally in the diet especially in soybeans and soy-based foods. Genistein and related phytoestrogens are of interest as chemopreventive agents for a variety of diseases and cancers based on epidemiologic evidence of reduced cancer rates in populations with a high intake of soy.
R, Michael McClain, Erich, Wolz, Alberto, Davidovich, Jochen, Bausch   +3 more
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The conversion of genistein to equol in the fowl

Biochimica et Biophysica Acta (BBA) - General Subjects, 1964
Abstract The possibility that equol in the urine of the domestic fowl may represent a conversion product of genistein has been investigated. Genistein was randomly tritiated by the Wilzbach process and purified by repeated crystallization and paper chromatography. The purified material was injected intramuscularly into a non-laying hen. The urine for
M N, CAYEN, A L, CARTER, R H, COMMON
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Radical scavenging properties of genistein

Free Radical Biology and Medicine, 2003
The reactivity of genistein toward reactive radical species has been investigated by means of pulse radiolysis. The values of rate constants, respectively 2.3 x 10(10) M(-1)s(-1) and 1.3 x 10(10) M(-1)s(-1) for the reaction with hydroxyl radical at pH 8.3 and 3.0, are close to diffusion limit indicating that genistein is a potent hydroxyl radical ...
Jacek, Zielonka, Jerzy, Gebicki, Grzegorz, Grynkiewicz   +2 more
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Pharmacological postconditioning with the phytoestrogen genistein

Journal of Molecular and Cellular Cardiology, 2007
Estrogens are known to activate the phosphatidyl-inosityl 3-kinase (PI3K)/Akt pathway, which is central in the cardioprotection afforded by ischemic postconditioning. Therefore, our goal was to investigate whether a phytoestrogen, genistein, could induce a pharmacological postconditioning and to investigate potential mechanisms.
Tissier, Renaud, Waintraub, X., Couvreur, N., Gervais, M., Bruneval, P., Mandet, C., Zini, R., Enriquez, B., Bruneval, A., Ghaleh, B.   +9 more
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