Results 71 to 80 of about 66,106 (160)
ABSTRACT Species lacking distinct secondary sex characteristics, such as differences in size or morphology, are often thought to experience lower levels of sex‐specific selection in comparison to highly sexually dimorphic organisms. However, monomorphism in classic visible traits could be a result of genetic or physiological constraints that prevent ...
Nicole M. Tosto+4 more
wiley +1 more source
Demystifying “Hyaline Angiopathy” of Pulse Granuloma in Oral and Extraoral Surgical Pathology
ABSTRACT Background and Objectives Pulse granuloma (PG), or giant cell hyaline angiopathy, is an immune‐mediated reaction often following the implantation of plant‐derived food particles. PGs are primarily found in the oral cavity and gastrointestinal tract and may represent a histopathological pitfall, being mistaken for other granulomatous conditions
Felipe Fornias Sperandio+3 more
wiley +1 more source
In the present work with mouse models, we demonstrate that a novel compound, NEO400, is able to profoundly protect skin against damage caused by UV radiation (UVR) when it is applied to skin post‐UVR exposure. In comparison, Aloe vera or linoleic acid are unable to achieve a similar level of protection.
Stephen Swenson+6 more
wiley +1 more source
Germ cell and other tumors in individuals with differences in sex development
Abstract Approximately one in 3500 to one in 5100 live‐born infants have atypical external genital development, known as differences in sex development (DSD). In 2005, an expert consensus conference thoroughly reviewed aspects of health care for individuals with DSD.
Selma Feldman Witchel+1 more
wiley +1 more source
Abstract Hyaluronan (HA), a large extracellular matrix glycosaminoglycan, is associated with malignant features in several human cancers. The accumulation of HA in renal cell carcinomas (RCC) correlates with unfavorable outcomes, higher tumor grade, and more advanced disease stages.
Otto Jokelainen+5 more
wiley +1 more source
Developmental Disturbances in Animal Models of Autism Spectrum Disorder
ABSTRACT Although the early signs of autism spectrum disorder (ASD) are widely studied, the significant ambiguity and heterogeneity in symptoms require the comparison of available models, approaches, and the search for common denominators and key indicators.
Kristof Laszlo+3 more
wiley +1 more source
ABSTRACT Background Adenoid cystic carcinoma (ACC) is an aggressive therapy‐resistant head and neck cancer with a high frequency of local recurrences and distant metastases. Activation of the MYB gene, encoding an oncogenic master transcription factor, is the key genomic hallmark of ACC and a potential therapeutic target. Here, we have investigated the
Fredrik Jäwert+5 more
wiley +1 more source
The Interplay of Cross‐Organ Immune Regulation in Inflammation and Cancer
Organs interact dynamically through immune regulation, influencing systemic immune responses and disease progression. We review molecular and cellular mechanisms of cross‐organ immune regulation in inflammation and cancer, focusing on gut, liver, and brain interactions with other organs.
Jie Dou+6 more
wiley +1 more source
Canine ovarian gonadoblastoma (GB) (with SALL4, OCT‐4, E‐cadherin, α‐inhibin, AE1/AE3, and WT‐1 immunoreactivity) and two mammary carcinomas have been described in a genetically normal female Spitz. The scarcity of GB in dogs, aberrant WT‐1 expression in the germ cell component, and lack of the AMELY gene are the most remarkable features of the present
Diba Golchin+4 more
wiley +1 more source
Phenotype and gene signature of testicular tumors in 129.MOLF‐Chr19 mice resemble human teratomas
Abstract Background Testicular germ cell tumor (TGCT) is the most common type of tumor in young men. Type II germ cell tumors including postpubertal‐type teratomas are derived from the germ cell neoplasia in situ (GCNIS), whereas prepubertal‐type teratomas arise independently of the GCNIS.
Fabian A. Gayer+4 more
wiley +1 more source