Results 21 to 30 of about 34,011 (232)

HDAC4 regulates apoptosis in Acan‐CreERT2;HDAC4d/d mice with osteoarthritis by downregulating ATF4

FEBS Open Bio, EarlyView.
Using the AcanCreERT2;HDAC4fl/fl genetic mouse model, we further investigated the role of histone deacetylase 4 (HDAC4) in chondrocyte apoptosis. We found that knocking down HDAC4 may be associated with chondrocyte apoptosis by upregulating the activating transcription factor 4 (ATF4)/CAAT/enhancer binding protein homologous (CHOP) signaling pathway ...
Jingrui Huang, Yukun Xu, Yujia Li, Yiming Pang, Xueting Ding, Raorao Zhou, Dan Liang, Xianda Che, Yuanyu Zhang, Chunfang Wang, Wenjin Li, Pengcui Li   +11 more
wiley   +1 more source

What do Portuguese people die of? [PDF]

, 2018
Nowadays, in developed countries as Portugal, deaths are essentially concentrated at old and very old ages, but it is still rather important to identify main causes of death (CODs).
Ribeiro, Filipe
core  

Evaluation of daily residual pancreatic tumor motion for deep‐inspiration breath‐hold radiotherapy

Journal of Applied Clinical Medical Physics, EarlyView.
Abstract Purpose Breath‐hold techniques are widely used in radiation therapy to minimize respiratory‐induced tumor or organ‐at‐risk motion. However, residual motion persists, necessitating a reliable daily evaluation method. Methods At our institution, fiducial markers serve as surrogates for target localization in pancreatic cancer treatment.
Weihua Mao, Binbin Wu, Kai Ding, Sarah Han‐Oh, Amol Narang   +4 more
wiley   +1 more source

A comparative analysis of deep learning architectures with data augmentation and multichannel input for locoregional breast cancer radiotherapy

Journal of Applied Clinical Medical Physics, EarlyView.
Abstract Purpose Studies on deep learning dose prediction increasingly focus on 3D models with multiple input channels and data augmentation, which increases the training time and thus also the environmental burden and hampers the ease of re‐training. Here we compare 2D and 3D U‐Net models with clinical accepted plans to evaluate the appropriateness of
Rosalie Klarenberg, Nienke L. M. Bakx, Coen W. Hurkmans   +2 more
wiley   +1 more source

Radiographic Atlas of the Genitourinary System [PDF]

, 1966
Saul Boyarsky
  +4 more sources

Artificial Receptor in Synthetic Cells Performs Transmembrane Activation of Proteolysis

Advanced Biology, EarlyView.
Transmembrane signaling is the hallmark of living cells and is among the highest challenges for the design of synthetic cells. Herein, an artificial receptor based on the chemistry of self‐immolative linkers is used to communicate information across the lipid bilayer, for transmembrane activation of enzymatic activity. Abstract The design of artificial,
Ane Bretschneider Søgaard, Kaja Borup Løvschall, Mireia Casanovas Montasell, Clara Bakkegaard Cramer, Pere Monge Marcet, Andreas Bøtker Pedersen, Josefine Hammer Jakobsen, Alexander N. Zelikin   +7 more
wiley   +1 more source

Preventive Effect of Metformin in Radiation‐Induced Xerostomia

Advanced Biology, EarlyView.
Head and neck cancer patients who received radiotherapy complain of severe dry mouth due to damage to the salivary glands. Metformin is an antidiabetic drug, but its radio‐protective effect has been reported. It is confirmed that metformin protects the salivary glands from radiation and provides evidence for the use of metformin in cancer treatment in ...
Sungryeal Kim, Jeong‐Mi Kim, Eun‐Jeong Jeon, Seo‐Young Park, Jin‐Mi Park, Jeong‐Seok Choi   +5 more
wiley   +1 more source

RhoA and Rac1 as Mechanotransduction Mediators in Colorectal Cancer

Advanced Biology, EarlyView.
Analysing RhoA and Rac1 protein levels in Colorectal cancer (CRC) samples under mechanical strain highlights their potential as diagnostic markers. Monitoring their activity could offer valuable insights into how cancer spreads, paving the way for new approaches to better understand and diagnose colorectal cancer.
Sharda Yadav, Sanjaya KC, Mark A. T. Blaskovich, Cu‐tai Lu, Alfred K Lam, Nam‐Trung Nguyen   +5 more
wiley   +1 more source

Renal cell carcinoma: a nomogram for the CT imaging-inclusive prediction of indolent, non-clear cell renal cortical tumours [PDF]

, 2016
Aim To develop a nomogram from clinical and computed tomography (CT) data for pre-treatment identification of indolent renal cortical tumours. Patients and methods A total of 1201 consecutive patients underwent dedicated contrast-enhanced CT prior to ...
Asnis-Alibozek, Cardone, Hindman, Karlo, Karlo, Karlo, Kim, Kovacs, Lane, Lowrance, Moch, Raj, Sasiwimonphan, Truong, Vargas, Young   +15 more
core   +1 more source

Development of Ternary Magnesium Alloys for Laser Powder Bed Fusion: Optimizing Oxide Layer Thickness

Advanced Engineering Materials, EarlyView.
Additive manufacturing of magnesium alloys by laser is difficult because the melting point of the oxide layer is much higher than the evaporation temperature of the metal underneath. Making the oxide layer thinner can solve this problem. Alloying magnesium with strontium makes the oxide layer thinner, especially at 0.5 wt%.
Elmar Jonas Breitbach, Stefan Julmi, Sabine Behrens, Tatiana Blank, Arvid Abel, Nicole Emminghaus, Ludger Overmeyer, Christian Klose, Hans Jürgen Maier   +8 more
wiley   +1 more source