Results 51 to 60 of about 353,350 (233)

Failure of phylogeny inferred from multilocus sequence typing to represent bacterial phylogeny

Scientific Reports, 2017
Although multilocus sequence typing (MLST) is highly discriminatory and useful for outbreak investigations and epidemiological surveillance, it has always been controversial whether clustering and phylogeny inferred from the MLST gene loci can represent ...
Alan K. L. Tsang, Hwei Huih Lee, Siu-Ming Yiu, Susanna K. P. Lau, Patrick C. Y. Woo   +4 more
doaj   +1 more source

The Evolution of Bacterial Genome Architecture

Frontiers in Genetics, 2017
The genome architecture of bacteria and eukaryotes evolves in opposite directions when subject to genetic drift, a difference that can be ascribed to the fact that bacteria exhibit a mutational bias that deletes superfluous sequences, whereas eukaryotes ...
Louis-Marie Bobay, Howard Ochman
doaj   +1 more source

Bacterial evolution: Jittery genomes [PDF]

Current Biology, 1999
Recent studies of long-term experimental populations of bacteria have revealed the actual progression of evolutionary change and how rates of phenotypic evolution can be decoupled from rates of genomic evolution.
openaire   +2 more sources

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Accurately assembling nanopore sequencing data of highly pathogenic bacteria

BMC Genomics
Background Bacterial genome exploration and outbreak analysis rely heavily on robust whole-genome sequencing and bioinformatics analysis. Widely-used genomic methods, such as genotyping and detection of genetic markers demand high sequencing accuracy and
Christine Thomas, Hanka Brangsch, Valentina Galeone, Martin Hölzer, Manja Marz, Jörg Linde   +5 more
doaj   +1 more source

A global resource for genomic predictions of antimicrobial resistance and surveillance of Salmonella Typhi at pathogenwatch

Nature Communications, 2021
Whole genome sequencing data are increasingly becoming routinely available but generating actionable insights is challenging. Here, the authors describe Pathogenwatch, a web tool for genomic surveillance of S.
Silvia Argimón, Corin A. Yeats, Richard J. Goater, Khalil Abudahab, Benjamin Taylor, Anthony Underwood, Leonor Sánchez-Busó, Vanessa K. Wong, Zoe A. Dyson, Satheesh Nair, Se Eun Park, Florian Marks, Andrew J. Page, Jacqueline A. Keane, Stephen Baker, Kathryn E. Holt, Gordon Dougan, David M. Aanensen   +17 more
doaj   +1 more source

The anti‐CRISPR protein AcrIE8.1 inhibits the type I‐E CRISPR‐Cas system by directly binding to the Cascade subunit Cas11

FEBS Letters, EarlyView.
In this study, we present the structure of AcrIE8.1, a previously uncharacterized anti‐CRISPR protein that inhibits the type I‐E CRISPR‐Cas system. Through a combination of structural and biochemical analyses, we demonstrate that AcrIE8.1 directly binds to the Cas11 subunit of the Cascade complex to inhibit the CRISPR‐Cas system.
Young Woo Kang, Hyun Ho Park
wiley   +1 more source

The influence of the accessory genome on bacterial pathogen evolution [PDF]

, 2011
Bacterial pathogens exhibit significant variation in their genomic content of virulence factors. This reflects the abundance of strategies pathogens evolved to infect host organisms by suppressing host immunity.
Abu-Ali GS, Adiba S, Alfano JR, Arnold DL, Arnold DL, Arnold DL, Asadulghani M, Baharoglu Z, Baquero F, Barash I, Blondel CJ, Blondel CJ, Brüssow H, Cambray G, Chen J, Chen Y, Choi J, Colinon C, Croucher NJ, Dawes FE, De Gelder L, Diard M, Dillon SC, Douard G, Doyle M, Elsaied H, Fondi M, Freeman VJ, Gartemann KH, Gillings MR, Godfrey SAC, Govind R, Greenberg JT, Grillot-Courvalin C, Groisman EA, Guerin E, Hacker J, Hacker J, Halary S, Hassan F, Hazen TH, Hegstad K, Heinemann JA, Heringa S, Hochhut B, Holden MT, Huang L, Imamovic L, Jackson RW, Jackson RW, Jenner C, Joss M, Jové T, Kearney B, Kers JA, Kiiru JN, Koenig JE, Koenig JE, Krauland MG, Landgraf A, Larsson P, Leplae Rl, León G, Lipps HJ, Lloyd AL, Loftie-Eaton W, Lovell HC, Lovell HC, Manning SD, Marchetti M, Matz C, Maurelli AT, Mazel D, Michael CA, Michael CA, Morris CE, Morris CE, Moura A, Naas T, Nadarasah G, Naka H, Nawaz M, Ogura Y, Paauw A, Partridge SR, Pitman A, Poirel L, Poirel L, Ramirez MS, Rankin DJ, Rezzonico F, Rivas LA, Rodriguez-Martinez JM, Rohmer L, Rosewarne CP, Sajjad A, Salanoubat M, Salzberg SL, Seth-Smith H, Shaheen BW, Siguier P, Siguier P, Smillie C, Smith AB, Song H, Sota M, Steinberg KM, Sundin GW, Sundin GW, Tao L, Treangen TJ, van der Meer JR, van der Veen EL, van Essen-Zandbergen A, Wagner A, Waldor MK, Wiesner M, Woodford N, Yang H, Zhou Z, Zupan J   +120 more
core   +2 more sources

An intracellular transporter mitigates the CO2‐induced decline in iron content in Arabidopsis shoots

FEBS Letters, EarlyView.
This study identifies a gene encoding a transmembrane protein, MIC, which contributes to the reduction of shoot Fe content observed in plants under elevated CO2. MIC is a putative Fe transporter localized to the Golgi and endosomal compartments. Its post‐translational regulation in roots may represent a potential target for improving plant nutrition ...
Timothy Mozzanino, Meijie Li, Cécile Fizames, Mattia Adamo, Laurence Lejay, Christian Dubos, Matthieu Platre, Antoine Martin   +7 more
wiley   +1 more source

The Landscape of Realized Homologous Recombination in Pathogenic Bacteria [PDF]

, 2015
Recombination enhances the adaptive potential of organisms by allowing genetic variants to be tested on multiple genomic backgrounds. Its distribution in the genome can provide insight into the evolutionary forces that underlie traits, such as the ...
Didelot, X, Falush, D, Jolley, KA, Kobayashi, I, Maiden, MCJ, Sheppard, SK, Yahara, K   +6 more
core   +2 more sources