Results 71 to 80 of about 124,479 (257)

Leptin May Promote Eosinophilic CRSwNP Progression by Enhancing Eosinophil Chemotaxis and Angiogenesis Under a Type 2 Inflammatory Milieu

open access: yesInternational Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Chronic rhinosinusitis with nasal polyp (CRSwNP) is a heterogeneous Type 2 inflammatory disease characterized by enhanced eosinophilic infiltration. Both innate and adaptive immunity are involved in the onset and progression of CRSwNP.
Yuki Sonoda   +4 more
wiley   +1 more source

Microbial‐Metabolite Signatures Are Associated With Glucocorticoid Responsiveness in Chronic Rhinosinusitis With Nasal Polyps

open access: yesInternational Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Patients with chronic rhinosinusitis with nasal polyps (CRSwNP) exhibit heterogeneous responses to oral glucocorticoids (GCs), but the biological basis of this variability remains unclear. Objective To identify gut microbiome‒plasma metabolomic signatures associated with GC responsiveness in CRSwNP patients and to compare their ...
Ying‐Ying Zhang   +7 more
wiley   +1 more source

Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses

open access: yesCommunications Biology
Thermophily is a trait scattered across the fungal tree of life, with its highest prevalence within three fungal families (Chaetomiaceae, Thermoascaceae, and Trichocomaceae), as well as some members of the phylum Mucoromycota. We examined 37 thermophilic
Andrei S. Steindorff   +29 more
doaj   +1 more source

Draft genome sequence data of Cercospora kikuchii, a causal agent of Cercospora leaf blight and purple seed stain of soybeans

open access: yesData in Brief, 2019
Cercospora kikuchii (Tak. Matsumoto & Tomoy.) M.W. Gardner 1927 is an ascomycete fungal pathogen that causes Cercospora leaf blight and purple seed stain on soybean. Here, we report the first draft genome sequence and assembly of this pathogen.
Francisco J. Sautua   +8 more
doaj   +1 more source

Evolutionary, Functional and Mechanistic Characterisation of Microbial Terpene Synthase‐Like Genes From Springtails

open access: yesAngewandte Chemie International Edition, EarlyView.
A genome analysis revealed the presence of many bacterial‐type terpene synthases in springtails. Four enzymes from Sinella curviseta were functionally characterised, resulting in the isolation of several compounds including sinellene ether, the first diterpene ether identified from a terpene synthase that represents a novel skeleton.
Min Wang   +5 more
wiley   +1 more source

Draft genome sequence of Aspergillus flavus isolate TERIBR1, a highly tolerant fungus to chromium stress

open access: yesBMC Research Notes, 2019
Objectives Aspergillus flavus isolate TERIBR1 was isolated from tannery sludge highly contaminated with chromium. During characterization process, it exhibited capability to adapt and grow in fungal growth media amended with chromium concentration as ...
Pushplata Prasad Singh   +3 more
doaj   +1 more source

Fungal Genomics

open access: yes, 2020
In the past two decades, genomics has developed into a formidable tool to study various aspects of fungi. New sequencing technologies have considerably driven down the costs, making genome sequencing available to a large group of researchers. However, gene prediction, functional analysis, and comparative genomics remain challenging.
openaire   +2 more sources

Population genomics of Vitis pseudoreticulata reveals the genetic basis of fungal resistance in grapevine

open access: yesHorticultural Plant Journal
Grapevine cultivation is facing significant challenges from fungal diseases. Wild Vitis species exhibit extraordinary fungal resistance, offering valuable genetic resources for grapevine improvement, yet their genetic basis of fungal resistance remains ...
Zhen Zhang   +18 more
doaj   +1 more source

Discovery of an Antiviral Electron Transfer Process to Create Catalytically Self‐Sufficient Viral Restriction Factors

open access: yesAngewandte Chemie International Edition, EarlyView.
CYB5R3 is identified as a putative electron‐transfer partner of viperin (RSAD2), explaining why ER localisation is required for antiviral activity. Its utilisation enabled the engineering of immune‐silent, catalytically self‐sufficient antiviral restriction factor enzymes (iCAREs) that produce an antiviral nucleoside triphosphate analogue (ANTA ...
Mengdi Wu   +16 more
wiley   +1 more source

Disentangling the importance of microbiological and physico-chemical properties of Ethiopian field soils for the Striga seed bank and sorghum infestation

open access: yesEnvironmental Microbiome
Background Striga hermonthica (Striga) is a parasitic weed that severely affects sorghum yield in sub-Saharan Africa. Recent studies highlighted the soil microbiome’s potential to suppress Striga through interference with specific stages in its life ...
Tamera Taylor   +22 more
doaj   +1 more source

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