Results 91 to 100 of about 16,403 (216)

Genome-wide analyses reveal the IRE1a-XBP1 pathway promotes T helper cell differentiation by resolving secretory stress and accelerating proliferation

Genome Medicine, 2018
Background The IRE1a-XBP1 pathway is a conserved adaptive mediator of the unfolded protein response. The pathway is indispensable for the development of secretory cells by facilitating protein folding and enhancing secretory capacity.
Jhuma Pramanik, Xi Chen, Gozde Kar, Johan Henriksson, Tomás Gomes, Jong-Eun Park, Kedar Natarajan, Kerstin B. Meyer, Zhichao Miao, Andrew N. J. McKenzie, Bidesh Mahata, Sarah A. Teichmann   +11 more
doaj   +1 more source

Advancing Tuberculosis Chemotherapy: Targeted Nanomedicines for the Mycobacterium TB Granuloma

Small, Volume 21, Issue 49, December 10, 2025.
This graphical abstract illustrates nanosystems used for targeted drug delivery into tuberculosis granulomas. It shows how targeting is influenced by size, pH, redox sensitivity, and surface charge. Various nanoparticles are incorporated with drugs to enhance penetration, stability, and release.
Shreya Ranjith Singh, Maya Mellisa Makatini, Thashree Marimuthu, Yahya Essop Choonara   +3 more
wiley   +1 more source

Comparative transcriptomics of stickleback immune gene responses upon infection by two helminth parasites, Diplostomum pseudospathaceum and Schistocephalus solidus [PDF]

, 2016
Immune systems of vertebrates are much more diverse than previously thought, in particular at the base of the vertebrate clade. RNA-seq was used to describe in detail the transcriptomic response of stickleback hosts to infection by two helminth parasites,
Bornberg-Bauer, Erich, Haase, David, Kalbe, Martin, Reusch, Thorsten B.H., Rieger, Jennifer K., Scharsack, Jörn P., Schmidt-Drewello, Alexander, Stoll, Monika, Witten, Anika   +8 more
core   +1 more source

Genomic Analysis of Hair Sheep From West/Central Africa Reveals Unique Genetic Diversity and Ancestral Links to Breed Formation in the Caribbean

Molecular Ecology, Volume 34, Issue 24, December 2025.
ABSTRACT Cameroon Blackbelly sheep are a domestic breed of hair sheep from West/Central Africa. They are popular with small‐holder farmers in Cameroon as they are highly resilient to local environmental challenges and are prolific a‐seasonal breeders.
Pamela Wiener, Juliane Friedrich, Melissa M. Marr, Gustave Simo, Vincent N. Tanya, Keith T. Ballingall, Pavel Flegontov, Benjamin D. Rosen, Guillaume Sallé, Gordon Spangler, Curtis P. Van Tassell, Mazdak Salavati, Félix Meutchieye, Emily L. Clark   +13 more
wiley   +1 more source

Evolution of Th2 responses : Characterization of IL-4/13 in sea bass (Dicentrarchus labrax L.) and studies of expression and biological activity [PDF]

, 2017
Acknowledgements This research was funded by the European Commission under the 7th Framework Programme for Research and Technological Development (FP7) of the European Union (Grant Agreement 311993 TARGETFISH). T.W.
A Antczak, A Bhattacharjee, A Munitz, AE Lockyer, E Wangkahart, EJ Song, F Buonocore, F Takizawa, G Biswas, G Scapigliati, H Nielsen, J Zhu, J Zou, JE Allen, JH Li, JW Hodgkinson, K Bao, K Tamura, L-y Zhu, LM Braden, M Howard, M Ohtani, M Tine, M Wills-Karp, MG Reese, MM Costa, MO Huising, N Nunez Ortiz, PJ Lupardus, RC Edgar, RL Coffman, S Almeria, S Kumar, S McCormick, SP Gadani, T Hage, T Maehr, T Wang, T Wang, T Wang, T Wang, T Yamaguchi, T Yamaguchi, TA Wynn, TA Wynn   +44 more
core   +1 more source

The European Union One Health 2024 Zoonoses Report

EFSA Journal, Volume 23, Issue 12, December 2025.
Abstract This report by the European Food Safety Authority and the European Centre for Disease Prevention and Control presents the results of zoonoses monitoring and surveillance activities carried out in 2024 in 27 Member States (MSs), the United Kingdom (Northern Ireland) and eight non‐MSs, according to the Zoonoses Directive 2003/99/EC.
European Food Safety Authority (EFSA) | European Centre for Disease Prevention and Control (ECDC)
wiley   +1 more source

Definitive host influences the proteomic profile of excretory/secretory products of the trematode Echinostoma caproni [PDF]

, 2016
Detailed gel images of the differential spots identified by mass spectrometry and database search. Magnification of the 2D gel-areas corresponding to the 19 differentially expressed spots identified by mass spectrometry and database search.
Alba Cortés, Carla Muñoz-Antolí, J. Guillermo Esteban, Javier Sotillo, María Trelis, Rafael Toledo   +5 more
core   +5 more sources

Report on the 2nd MObility for Vesicle research in Europe (MOVE) symposium—2024

FEBS Open Bio, Volume 15, Issue 11, Page 1726-1737, November 2025.
The 2nd MObility for Vesicle research in Europe (MOVE) Symposium in Belgrade brought over 280 attendees from 28 countries to advance extracellular vesicle (EV) research. Featuring keynotes, presentations, and industry sessions, it covered EV biogenesis, biomarkers, therapies, and manufacturing.
Dorival Mendes Rodrigues‐Junior, Michaela Kocholata, Marilena E. Lekka, Olga Janouskova, Moran Yadid, Maja Kosanovic   +5 more
wiley   +1 more source

Profiling G protein-coupled receptors of Fasciola hepatica identifies orphan rhodopsins unique to phylum Platyhelminthes

International Journal for Parasitology: Drugs and Drug Resistance, 2018
G protein-coupled receptors (GPCRs) are established drug targets. Despite their considerable appeal as targets for next-generation anthelmintics, poor understanding of their diversity and function in parasitic helminths has thwarted progress towards GPCR-
Paul McVeigh, Erin McCammick, Paul McCusker, Duncan Wells, Jane Hodgkinson, Steve Paterson, Angela Mousley, Nikki J. Marks, Aaron G. Maule   +8 more
doaj   +1 more source

Diversity in parasitic nematode genomes: the microRNAs of Brugia pahangi and Haemonchus contortus are largely novel [PDF]

, 2012
<b>BACKGROUND:</b> MicroRNAs (miRNAs) play key roles in regulating post-transcriptional gene expression and are essential for development in the free-living nematode Caenorhabditis elegans and in higher organisms.
Berriman, M., Britton, C., Devaney, E., Gilleard, J.S., Hunt, M., Weir, W., Winter, A.D.   +6 more
core   +4 more sources