Results 101 to 110 of about 16,403 (216)

Editorial: Novel Frontiers in Helminth Genomics [PDF]

Frontiers in Genetics, 2020
Jose F. Tort, Makedonka Mitreva, Klaus R. Brehm, Gabriel Rinaldi   +3 more
openaire   +3 more sources

CRISPR/Cas genome editing, functional genomics, and diagnostics for parasitic helminths

International Journal for Parasitology
Functional genomics using CRISPR (Clustered Regulatory Interspaced Short Palindromic Repeats)/Cas (CRISPR-associated endonuclease)-based approaches has revolutionized biomedical sciences. Gene editing is also widespread in parasitology generally and its use is increasing in studies on helminths including flatworm and roundworm parasites.
Koike, Akito, Brindley, Paul J.
openaire   +2 more sources

Evidence of selection as a cause for racial disparities in fibroproliferative disease.

PLoS ONE, 2017
Fibroproliferative diseases are common complex traits featuring scarring and overgrowth of connective tissue which vary widely in presentation because they affect many organ systems.
Jacklyn N Hellwege, Eric S Torstenson, Shirley B Russell, Todd L Edwards, Digna R Velez Edwards   +4 more
doaj   +1 more source

HelmCoP: An Online Resource for Helminth Functional Genomics and Drug and Vaccine Targets Prioritization

PLoS ONE, 2011
A vast majority of the burden from neglected tropical diseases result from helminth infections (nematodes and platyhelminthes). Parasitic helminthes infect over 2 billion, exerting a high collective burden that rivals high-mortality conditions such as AIDS or malaria, and cause devastation to crops and livestock.
Abubucker, Sahar, Martin, John, Taylor, Christina M., Mitreva, Makedonka   +3 more
openaire   +6 more sources

Repurposing of anticancer drugs: in vitro and in vivo activities against Schistosoma mansoni

Parasites & Vectors, 2015
Background Drug discovery for the neglected tropical disease schistosomiasis has a high priority. Anticancer drugs, especially protein kinase inhibitors, might serve as a starting point for drug discovery owing to the importance of protein kinases in ...
Noemi Cowan, Jennifer Keiser
doaj   +1 more source

WormBase: A modern Model Organism Information Resource [PDF]

, 2020
WormBase (https://wormbase.org/) is a mature Model Organism Information Resource supporting researchers using the nematode Caenorhabditis elegans as a model system for studies across a broad range of basic biological processes.
et al,, Harris, Todd W, Schedl, Tim
core   +1 more source

Schistosoma mansoni Infection-Induced Transcriptional Changes in Hepatic Macrophage Metabolism Correlate With an Athero-Protective Phenotype

Frontiers in Immunology, 2018
Hepatic macrophages play an essential role in the granulomatous response to infection with the parasitic helminth Schistosoma mansoni, but the transcriptional changes that underlie this effect are poorly understood.
Diana Cortes-Selva, Andrew F. Elvington, Andrew F. Elvington, Andrew Ready, Bartek Rajwa, Edward J. Pearce, Gwendalyn J. Randolph, Keke C. Fairfax, Keke C. Fairfax   +8 more
doaj   +1 more source

Helminth parasite proteomics: from experimental models to human infections [PDF]

, 2012
Schistosomiasis is a major human helminth infection endemic in developing countries. Urogenital schistosomiasis, caused by S. haematobium, is the most prevalent human schistosome disease in sub-Saharan Africa.
Anderson, FRANCISCA MUTAPI, Grzych, Kwan-Lim, Lopez, Zhou   +5 more
core   +2 more sources

The Schistosoma mansoni phylome: using evolutionary genomics to gain insight into a parasite’s biology

BMC Genomics, 2012
Background Schistosoma mansoni is one of the causative agents of schistosomiasis, a neglected tropical disease that affects about 237 million people worldwide.
Silva Larissa, Marcet-Houben Marina, Nahum Laila, Zerlotini Adhemar, Gabaldón Toni, Oliveira Guilherme   +5 more
doaj   +1 more source

Diversification of the Caenorhabditis heat shock response by Helitron transposable elements. [PDF]

, 2019
Heat Shock Factor 1 (HSF-1) is a key regulator of the heat shock response (HSR). Upon heat shock, HSF-1 binds well-conserved motifs, called Heat Shock Elements (HSEs), and drives expression of genes important for cellular protection during this stress ...
Ahringer, Altschul, Ashe, Bailey, Bourque, Brunquell, Casper, Cavrak, Christians, Chuong, Chuong, Contrino, Cook, Cook, Cutter, Esnault, Feschotte, Fierst, Fuentes, Gonsalves, Grabundzija, Grant, Guertin, Gupta, Halfon, Ho, Howe, Howe, Huang, Huang, Hubley, Ito, Jedlicka, Jiang, Johnstone, Jordan, Kanzaki, Kapitonov, Kapitonov, Kent, Kojima, Labbadia, Langmead, Lee, Li, Li, Li, Liu, Love, Mahat, Maman, Mao, Mark, Matys, McClintock, Mendillo, Mortazavi, Narasimhan, Narasimhan, Patro, Perisic, Pontis, R Development Core Team, Rausch, Santos, Schreiner, Shirayama, Slos, Slotkin, Solís, Stevens, Sun, Sundaram, Sundaram, Tajima, Takaki, Thomas, Thomas, Thomas, Todd, Verster, Vihervaara, Weirauch, Wood, Zhang   +84 more
core   +2 more sources