Results 111 to 120 of about 16,403 (216)

Cystatin from the helminth Ascaris lumbricoides upregulates mevalonate and cholesterol biosynthesis pathways and immunomodulatory genes in human monocyte-derived dendritic cells

Frontiers in Immunology
BackgroundAscaris lumbricoides cystatin (Al-CPI) prevents the development of allergic airway inflammation and dextran-induced colitis in mice models. It has been suggested that helminth-derived cystatins inhibit cathepsins in dendritic cells (DC), but ...
Nathalie Acevedo, Ana Lozano, Josefina Zakzuk, Kevin Llinás-Caballero, David Brodin, Peter Nejsum, Andrew R. Williams, Luis Caraballo   +7 more
doaj   +1 more source

Impact of Experimental Hookworm Infection on the Human Gut Microbiota [PDF]

, 2014
The interactions between gastrointestinal parasitic helminths and commensal bacteria are likely to play a pivotal role in the establishment of host-parasite cross-talk, ultimately shaping the development of the intestinal immune system.
Alex Loukas, Broadhurst, Caporaso, Cinzia Cantacessi, Cooper, Croese, Croese, Daveson, Gaze, Javier Sotillo, John Croese, Kumar, Leisa McCann, Li, Lutz Krause, Makedonka Mitreva, Martha Zakrzewski, Matthew J. Nolan, Muyzer, Paul Giacomin, Round, Sepehri, Summers, Walk, Yazdanbakhsh   +24 more
core   +3 more sources

The genetic basis of adaptive evolution in parasitic environment from the Angiostrongylus cantonensis genome.

PLoS Neglected Tropical Diseases, 2019
Angiostrongylus cantonensis (rat lungworm) is the etiological agent of angiostrongyliasis, mainly causing eosinophilic meningitis or meningoencephalitis in human. Although the biology of A. cantonensis is relatively well known, little is understood about
Lian Xu, Meng Xu, Xi Sun, Junyang Xu, Xin Zeng, Dai Shan, Dongjuan Yuan, Ping He, Weiming He, Yulan Yang, Shiqi Luo, Jie Wei, Xiaoying Wu, Zhen Liu, Xiaomin Xu, Zhensheng Dong, Langui Song, Beibei Zhang, Zilong Yu, Lifu Wang, Chi Zhang, Xiaodong Fang, Qiang Gao, Zhiyue Lv, Zhongdao Wu   +24 more
doaj   +1 more source

Biogeographical ancestry is associated with socioenvironmental conditions and infections in a Latin American urban population

SSM: Population Health, 2018
Racial inequalities are observed for different diseases and are mainly caused by differences in socioeconomic status between ethnoracial groups. Genetic factors have also been implicated, and recently, several studies have investigated the association ...
Thiago Magalhães da Silva, Rosemeire L. Fiaccone, Fernanda S.G. Kehdy, Eduardo Tarazona-Santos, Laura C. Rodrigues, Gustavo N.O. Costa, Camila A. Figueiredo, Neuza Maria Alcantara-Neves, Maurício L. Barreto   +8 more
doaj   +1 more source

Ascaris phylogeny based on multiple whole mtDNA genomes [PDF]

, 2016
Ascaris lumbricoides and A. suum are two parasitic nematodes infecting humans and pigs, respectively. There has been considerable debate as to whether Ascaris in the two hosts should be considered a single or two separate species.
Andersen, Lee O, Beston, Martha, Gasser, Robin B, Hawash, Mohamed B F, Nejsum, Peter, Stothard, Russell   +5 more
core   +3 more sources

Nematode control in 'green' ruminant production systems [PDF]

, 2004
Collectively, nematode parasites of domestic ruminants continue to pose the greatest disease problem in grazing livestock systems worldwide, despite the powerful and extensive chemotherapeutic arsenal available for their control.
Thamsborg, Stig M., Waller, Peter J.
core   +1 more source

Spatio-temporal diversity and genetic architecture of pyrantel resistance in Cylicocyclus nassatus, the most abundant horse parasite

Peer Community Journal
Cyathostomins are a complex of 50 intestinal parasite species infecting horses and wild equids. The massive administration of modern anthelmintic drugs has increased their relative abundance in horse helminth communities and selected drug-resistant ...
Sallé, Guillaume, Courtot, Élise, Cabau, Cédric, Parrinello, Hugues, Serreau, Delphine, Reigner, Fabrice, Gesbert, Amandine, Jacquinot, Lauriane, Lenhof, Océane, Aimé, Annabelle, Picandet, Valérie, Kuzmina, Tetiana, Holovachov, Oleksandr, Bellaw, Jennifer, Nielsen, Martin K., von Samson-Himmelstjerna, Georg, Valière, Sophie, Gislard, Marie, Lluch, Jérôme, Kuchly, Claire, Klopp, Christophe   +20 more
doaj   +1 more source

From parasite genomes to one healthy world: Are we having fun yet? [PDF]

, 2009
In 1990, the Human Genome Sequencing Project was established. This laid the ground work for an explosion of sequence data that has since followed. As a result of this effort, the first complete genome of an animal, Caenorhabditis elegans was published in
Gasbarre, Louis C., Zarlenga, Dante
core   +1 more source

Functional annotation and identification of novel drug targets from uncharacterized proteome of Trichuris trichiura

Journal of Infection in Developing Countries
Introduction: Trichuris trichiura, a soil-transmitted helminth, resides in the large intestine of humans, causing an asymptomatic disease known as trichuriasis.
Kanchan Rauthan, Saranya Joshi, Lokesh Kumar, Sudhir Kumar   +3 more
doaj   +1 more source

Helminth genome analysis: the current status of the filarial and schistosome genome projects. Filarial Genome Project. Schistosome Genome Project.

Parasitology, 1999
Genome projects for the parasitic helminths Brugia malayi (a representative filarial nematode) and Schistosoma were initiated in 1995 by the World Health Organization with the ultimate objectives of identifying new vaccine candidates and drug targets and of developing low resolution genome maps. Because no genetic maps are available, and very few genes
S A, Williams, D A, Johnston
openaire   +1 more source