Results 181 to 190 of about 11,509,666 (312)

Exploring the multifaceted Dbf4-dependent kinase from temporal, spatial, and substrate repertoire perspectives. [PDF]

Commun Biol
Galanti L, Pfander B.
europepmc   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Human Gut Phageome Analysis Uncovers Thousands of Highly Modular Endolysins. [PDF]

Microbiologyopen
Niloy RK, Jewel NA, Karim D, Rolin MH, Khan T, Akter A, Mondal SI.   +6 more
europepmc   +1 more source

MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis

FEBS Open Bio, EarlyView.
MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss, Ao Li, Eduardo H. Gilglioni, Mayank Bansal, Sumeet Pal Singh, Latifa Bakiri, Alessandra K. Cardozo, Esteban N. Gurzov   +7 more
wiley   +1 more source

The human genome and medicine

Anales de Pediatría (English Edition), 2018
Francesc Palau, Alfredo García-Alix
openaire   +3 more sources

Spatial organization and dynamics of genome replication: from forks to foci. [PDF]

Nucleic Acids Res
Pradhan SK, Arroyo M, Pabba MK, Leonhardt H, Cardoso MC.   +4 more
europepmc   +1 more source

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source

Characterizing cytosine methylation of polymorphic transposable element insertions using the human pangenome resources. [PDF]

Genome Res
Zhuo X, Tomlinson C, Belter EA, Kuntala PK, Saintilnord WN, Jiang J, Lindsay T, Macias-Velasco JF, Fulton RS, Wang T, Human Pangenome Reference Consortium.   +10 more
europepmc   +1 more source

Identification of (20R)‐protopanaxadiol from Panax ginseng as a novel anti‐SARS‐CoV‐2 compound

FEBS Open Bio, EarlyView.
We established a noninfectious BAC‐based SARS‐CoV‐2 replicon that enables antiviral screening under BSL‐2 conditions. Using this platform, we screened 373 food‐derived compounds and identified (20R)‐protopanaxadiol from Panax ginseng as a novel inhibitor of SARS‐CoV‐2 RNA replication, highlighting the value of safe replicon systems for antiviral ...
Midori Takeda, Natsue Maezono, Rina Uchikoshi, Nobuyuki Kato, Masanori Ikeda   +4 more
wiley   +1 more source

Mitochondrial genome microhomology-mediated editing by donor DNA delivery into mitochondria in human cells. [PDF]

Mol Ther Nucleic Acids
Maximov VV, Shebanov N, Nikitchina N, Rapoport R, Maor Y, Tarassov I, Pines O, Entelis N.   +7 more
europepmc   +1 more source