Results 151 to 160 of about 363,946 (316)

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Integrative multi-omics analysis widens annotation and functional insights into long non-coding RNAs of Arabidopsis thaliana

Biology Direct
Background Long non-coding RNAs (lncRNAs) play key roles in regulating plant growth, development, and stress responses. Despite their increasing identification in plant transcriptomes, a systematic characterization of lncRNAs is still lacking, leaving a ...
AT Vivek, Harikumar Kiran, Namrata Sahu, Garima Kalakoti, Shailesh Kumar   +4 more
doaj   +1 more source

Molecular dissection of quantitative variation in fiber elongation between Gossypium hirsutum and Gossypium barbadense in reciprocal near-isogenic lines

Frontiers in Plant Science
In reciprocal interspecific near-isogenic lines developed by crossing elite cultivars Acala Maxxa (Gossypium hirsutum) and Pima S6 (G. barbadense) representing the two major domesticated species of cotton, we identified genomic locations underpinning an ...
Jeevan Adhikari, Deepak Vitrakoti, Wiriyanat Ployaram, Sameer Khanal, Rahul Chandnani, Jinesh Patel, Tariq Shehzad, Peng Chee, Andrew H. Paterson   +8 more
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Comparative BAC end sequence analysis of tomato and potato reveals overrepresentation of specific gene families in potato

, 2008
Background Tomato (Solanum lycopersicon) and potato (S. tuberosum) are two economically important crop species, the genomes of which are currently being sequenced.
Visser Richard GF, Giovannoni James J, Stiekema, W., Datema, E., Ham, R.C.H.J., van, Datema Erwin, Mueller, L.A., van Ham Roeland CHJ, Visser, R.G.F., Giovannoni, J.J., Buels Robert, Mueller Lukas A, Stiekema Willem J, Buels, R.   +13 more
core   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Physical Mapping of the Genome of Arabidopsis thaliana by Fingerprinting of Yeast Artifical Chromosome Clones

, 1992
1
남홍길, Kim,D.U., Kim,Y.S, Knag, H.G
core  

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Measuring the loss of duplicated genes in plant genomes assembled by means of short reads.

, 2015
Introduction The assembly of a genome is a complex task, whose hardest step is the resolution of repeats. As these regions are usually considered of minor concern for the description of the features of the genome, they are often poorly characterized in ...
VEZZI, ALESSANDRO, DE PASCALE, FABIO, MARTINI, PAOLO   +2 more
core   +1 more source

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source