New compound sets identified from high throughput phenotypic screening against three kinetoplastid parasites:an open resource [PDF]
, 2015 Using whole-cell phenotypic assays, the GlaxoSmithKline high-throughput screening (HTS) diversity set of 1.8 million compounds was screened against the three kinetoplastids most relevant to human disease, i.e.
Alonso-Padilla, Julio +20 more
core +3 more sources
Experimental evolution of Legionella pneumophila in mouse macrophages leads to strains with altered determinants of environmental survival. [PDF]
PLoS Pathogens, 2012 The Gram-negative bacterium, Legionella pneumophila, is a protozoan parasite and accidental intracellular pathogen of humans. We propose a model in which cycling through multiple protozoan hosts in the environment holds L.
Alexander W Ensminger +3 more
doaj +1 more source
The FEBS Journal, EarlyView.Protein import into mitochondria relies on TIM complexes and the membrane potential. Trypanosoma brucei has a unique TIM complex, and the role of one subunit, TbTim20, has remained unclear. Here, we show that TbTim20 is essential in cells lacking mitochondrial DNA. The importance of TbTim20 increases as the membrane potential decreases.
Corinne von Känel +8 more
wiley +1 more source
Bioaugmentation mitigates the impact of estrogen on coliform-grazing protozoa in slow sand filters [PDF]
, 2016 Exposure to endocrine-disrupting chemicals (EDCs), such as estrogens, is a growing issue for human and animal health as they have been shown to cause reproductive and developmental abnormalities in wildlife and plants and have been linked to male ...
Collins, Gavin +3 more
core +10 more sources
Memorias do Instituto Oswaldo Cruz, 2011 Trypanosoma cruzi, a protozoan parasite that causes Chagas disease, exhibits unique mechanisms for gene expression such as constitutive polycistronic transcription of protein-coding genes, RNA editing and trans-splicing.
Patricia R Araújo, Santuza M Teixeira
doaj +1 more source
Repeat-Driven Generation of Antigenic Diversity in a Major Human Pathogen, Trypanosoma cruzi
Frontiers in Cellular and Infection Microbiology, 2021 Trypanosoma cruzi, a zoonotic kinetoplastid protozoan parasite, is the causative agent of American trypanosomiasis (Chagas disease). Having a very plastic, repetitive and complex genome, the parasite displays a highly diverse repertoire of surface ...
Carlos Talavera-López +27 more
doaj +1 more source
Exploring the Histone Acetylation Cycle in the Protozoan Model Tetrahymena thermophila
Frontiers in Cell and Developmental Biology, 2020 The eukaryotic histone acetylation cycle is composed of three classes of proteins, histone acetyltransferases (HATs) that add acetyl groups to lysine amino acids, bromodomain (BRD) containing proteins that are one of the most characterized of several ...
S. Wahab +4 more
semanticscholar +1 more source
The structural, functional, and therapeutic potential of metacaspases in fungi and protozoa
The FEBS Journal, EarlyView.Metacaspases are Ca2+‐dependent cysteine proteases whose structural characteristics, particularly calcium binding and autocatalytic processing, govern their activation and biological functions. These enzymes differ among microorganisms and regulate their cell cycles, making them excellent targets for drug development.
Ane C. M. Duarte +9 more
wiley +1 more source
Genome-wide analysis of 30 -untranslated regions supports the existence of post-transcriptional regulons controlling gene expression in trypanosomes [PDF]
, 2013 In eukaryotic cells, a group of messenger ribonucleic acids (mRNAs) encoding functionally interrelated proteins together with the trans-acting factors that coordinately modulate their expression is termed a post-transcriptional regulon, due to their ...
Agüero, Fernan Gonzalo +3 more
core +3 more sources
Benzoxaboroles Are Inhibitors of the η‐Class Carbonic Anhydrase From Plasmodium falciparum
Archiv der Pharmazie, Volume 359, Issue 2, February 2026.Benzoxaborole‐based inhibitors demonstrate potent, low‐micromolar inhibition of the essential malaria target PfaCA and are effective in vitro suppression of P. falciparum. Molecular docking confirms target engagement via zinc coordination, establishing this chemotype as a promising scaffold for the development of next‐generation antimalarials ...
Alessandro Bonardi +9 more
wiley +1 more source