Results 211 to 220 of about 1,052,313 (231)

Genomics, pathogenesis and control of infection with protozoan parasites

Trends in Parasitology, 2002
Abstract The XXVIII Annual Meeting of Basic Research on Chagas Disease and XVII Annual Meeting of the Brazilian Society of Protozoology were held 5–7 November, 2001, in Caxambu, Minas Gerais, Brazil.
Santuza M.R Teixeira, Leda Q Vieira, Ricardo T Gazzinelli   +2 more
openaire   +1 more source

Protozoan Genomes: Karyotype Analysis, Chromosome Structure, and Chromosome Specific Libraries

2003
Protozoa represent a diverse group of single-celled eukaryotes, many of which have parasitic life styles, infecting hundreds of millions of people. Unique aspects of their biology relate to their distinct evolutionary position and their complex life cycles, frequently involving different hosts.
L H, Van der Ploeg, K M, Gottesdiener, S H, Korman, M, Weiden, S L, Blancq   +4 more
openaire   +2 more sources

Amplification and sequencing of genomic DNA fragments encoding cysteine proteases from protozoan parasites

Molecular and Biochemical Parasitology, 1990
Cysteine protease gene fragments from three protozoan parasites Trypanosoma cruzi, Trypanosoma brucei, and Entamoeba histolytica were amplified by the polymerase chain reaction (PCR) from genomic DNA using degenerate oligonucleotide primers. The primers used for the amplification were designed based upon amino acid sequences flanking the active site ...
A E, Eakin, J, Bouvier, J A, Sakanari, C S, Craik, J H, McKerrow   +4 more
openaire   +2 more sources

Analysis of the genomes of protozoan parasites using PFGE

1995
Abstract Pulsed field gel electrophoresis (PFGE) has played a major role in developing our current knowledge of the genomes of a number of protozoan parasites as the genomes are small and the chromosomes usually fall within a usable size range. The studies on malaria and trypanosomatids described here demonstrate the applicability of the
David J Kemp, Roberto Cappai
openaire   +1 more source

Metalloaminopeptidases of the Protozoan Parasite Plasmodium falciparum as Targets for the Discovery of Novel Antimalarial Drugs.

Journal of Medicinal Chemistry, 2021
Malaria poses a significant threat to approximately half of the world's population with an annual death toll close to half a million. The emergence of resistance to front-line antimalarials in the most lethal human parasite species, Plasmodium falciparum
Belinda Mills, R. Isaac, R. Foster
semanticscholar   +1 more source

Genomics and Genetic Manipulation of Protozoan Parasites Affecting Farm Animals

2017
In this chapter we present a brief but state-of-the-art account of the genomics and current gene manipulation methods that can be used to improve our understanding of the genetics and the biology of an arbitrary group of 17 protozoan parasites responsible for diseases that affect animals worldwide, including babesiosis, toxoplasmosis, theileriosis ...
Carlos E. Suarez, Heba F. Alzan, Brian M. Cooke   +2 more
openaire   +1 more source

Many task computing for orthologous genes identification in protozoan genomes using Hydra

Concurrency and Computation: Practice and Experience, 2011
SUMMARYOne of the main advantages of using a scientific workflow management system (SWfMS) is to orchestrate data flows among scientific activities and register provenance of the whole workflow execution. Nevertheless, the execution control of distributed activities in high performance computing environments by SWfMS presents challenges such as ...
Fábio Coutinho, Eduardo Ogasawara, Daniel de Oliveira, Vanessa Braganholo, Alexandre A.B. Lima, Alberto M.R. Dávila, Marta Mattoso   +6 more
openaire   +1 more source

Post genomic analysis of permeases from the amino acid/auxin family in protozoan parasites

Biochemical and Biophysical Research Communications, 2004
The "amino acid/auxin permeases" is probably the most represented family of transporters in the Trypanosoma cruzi genome. Using a high-throughput searching routine and preliminary data from the T. cruzi genome project, more than 15,000 sequences were iteratively assembled into contigs, and 60 open reading frames corresponding to different putative ...
León A, Bouvier, Ariel M, Silber, Camila, Galvão Lopes, Gaspar E, Canepa, Mariana R, Miranda, Renata R, Tonelli, Walter, Colli, Maria Júlia M, Alves, Claudio A, Pereira   +8 more
openaire   +2 more sources

Are Carbonic Anhydrases Suitable Targets to Fight Protozoan Parasitic Diseases?

Current Medicinal Chemistry, 2019
Protozoans belonging to Plasmodium, Leishmania and Trypanosoma genera provoke widespread parasitic diseases with few treatment options and many of the clinically used drugs experiencing an extensive drug resistance phenomenon.
Katia D'Ambrosio, C. Supuran, G. De Simone   +2 more
semanticscholar   +1 more source

PROTOGIM: a novel tool to search motifs and domains in hypothetical proteins of protozoan genomes

Parasitology Research, 2005
Whole sequencing of protozoan trypanosomatid genomes revealed the presence of several predicted unknown genes coding for hypothetical proteins. Pairwise, alignment-based, computational methods available online are unable to identify the function of these sequences.
Igor S, Cestari, Nicolaas J, Haver, Adriano, Barbosa-Silva, Marcel I, Ramirez   +3 more
openaire   +2 more sources