Results 191 to 200 of about 669,373 (262)

Viral diversity in urban feline swab samples recovered using metagenomics. [PDF]

Microbiol Resour Announc
Kwon T, Youtsey B, Ruth N, Fair JM, Gleasner CD, Shakya M, Marghoob A, Bartlow AW.   +7 more
europepmc   +1 more source

STAT6 Activation Exacerbates Ferroptosis in Airway Epithelium by Inhibiting PRKN‐Mediated Mitophagy in Pulmonary Fibrosis

Advanced Science, EarlyView.
This study uncovers STAT6‐driven pulmonary fibrosis (PF) via suppression of PRKN‐mediated airway epithelial mitophagy, triggering mitochondrial dysfunction and ferroptosis. Rifabutin is identified as a potent STAT6 inhibitor that effectively reverses fibrotic progression. These findings reveal the STAT6‐PRKN axis as a pathogenic regulator and provide a
Youjing Yang, Guangbin Huang, Tao Zhang, Yi Ling, Junyu Jiang, Dingyuan Du, Yu Ma, Shasha Tao   +7 more
wiley   +1 more source

Epidemiology and Pathogenicity Analysis Based on Partial Recombinant PRRSV Strains in China. [PDF]

Transbound Emerg Dis
You S, Li L, Wang J, Luo L, Song J, Ju H, Yu L, Li G, Cui J.   +8 more
europepmc   +1 more source

Human Schlafen 14 Cleavage of Short Double‐Stranded RNAs Underpins its Antiviral Activity

Advanced Science, EarlyView.
SLFN14 is associated with human diseases. SLFN14 is found to cleave RNAs containing short duplexes. The cryo‐EM structures of SLFN14 and SLFN14‐hairpin RNA complex reveal that SLFN14 assembles into a ring‐like dimer; two RNase domains form an RNA‐binding groove accommodating a hairpin RNA.
Mengyun Li, Dapeng Sun, Wei Hao, Hua Fu, Yueli Zhang, Zhijian Li, Bo Qin, Yumei Wang, Sheng Cui   +8 more
wiley   +1 more source

Molecular characterization of human respiratory syncytial virus in Mexico (season 2023-2024) through whole-genome sequencing. [PDF]

Sci Rep
Rivera-Toledo E, Mejıa-Nepomuceno F, Mendoza-Ramırez E, Vera-Jimenez A, Becerril-Vargas E, Ahumada-Topete VH, Castillejos-Lopez M, Perez-Orozco FB, Benitez G, Salazar-Lezama MÁ, Cadeza-Aguilar JD, Garcia-Colin E, Garrido-Galindo C, Regalado-Pineda J, Collins JP, Lu XJ, Wickiser JK, Vazquez-Perez JA.   +17 more
europepmc   +1 more source

The TET3/GATA6 Axis Drives Lipid Metabolism and Therapeutic Vulnerabilities in Pancreatic Ductal Adenocarcinoma

Advanced Science, EarlyView.
The DNA demethylase TET3 drives lipid metabolic reprogramming in pancreatic ductal adenocarcinoma via a non‐catalytic mechanism. TET3 recruits histone deacetylases to repress GATA6, sustaining lipogenic enzyme expression and ferroptosis resistance.
Shuai Liu, Shaobo Kang, Na Lin, Wenqi Zhang, Shiwen Wang, Yuqing Ren, Xiaofan Ding, Jianxiu Yu, Ruiyu Xie   +8 more
wiley   +1 more source

"Snip, snip, cure"? Philosophical, legal and biomedical perspectives on novel somatic genomic therapies. [PDF]

Med Health Care Philos
Risse J, Pietrek L, Cantz T, Krzemien M, Schnalke J, Eggenschwiler R, Heinemann T, Dederer HG.   +7 more
europepmc   +1 more source

A Prion‐Like Domain in EBV EBNA1 Promotes Phase Separation and Enables SRRM1 Splicing

Advanced Science, EarlyView.
This study discoveries that EBV EBNA1 behaves as a prion‐like protein, verified using cell‐based assays and the Saccharomyces cerevisiae Sup35p prion identification system. The prion‐like domain of EBNA1 drives liquid–liquid phase separation. EBNA1 interacts with the splicing factor SRSF1 to regulate the expression of the SRRM1 splicing isoforms ...
Xiaoyue Zhang, Zhengshuo Li, Run Zheng, Xiang Zheng, Jia Wang, Can Liu, Yangge Wu, Yuqing Wen, Chunlin Ou, Songqing Fan, Chenxiao Xu, Junrui Tian, Qun Yan, Hao Nan, Xiaodong Xu, Hui Wang, Qiu Peng, Jian Ma   +17 more
wiley   +1 more source

Viral Enhancers Orchestrate Kaposi's Sarcoma-Associated Herpesvirus Transcription. [PDF]

J Med Virol
Chowdhury NR, Shamay M.
europepmc   +1 more source