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Viral genome organizer: a system for analyzing complete viral genomes
Virus Research, 2000The viral genome organizer (VGO) is designed to simplify the characterization and annotation of complete viral genomes (particularly those of large poxviruses) and to help researchers discover new genes and detect gene fragmentation. VGO is based on Genotator [Harris, N.L., 1997. Genome Res.
C, Upton +4 more
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A Model for Viral Genome Packing
Multiscale Modeling & Simulation, 2006A method is developed to simulate the process of double‐stranded (ds) DNA packing in viral capsids. The dsDNA is modeled as a discrete single‐stranded homopolymer with an all‐elastic potential that is parameterized only by the experimentally measured rise per base pair (bp) and the persistence length of free dsDNA in physiological conditions.
C. Rebecca Locker, Stephen C. Harvey
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Nature, 1975
DNA transcripts of infectious RNA viruses were found to be integrated in the DNA of chronically-infected tissue cultures. DNA sequences homologous to RNA of measles virus were found in tissues affected with systemic lupus erythemotosus. These data open up a new class of virus-cell interaction that may be a result of cooperation between infectious and
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DNA transcripts of infectious RNA viruses were found to be integrated in the DNA of chronically-infected tissue cultures. DNA sequences homologous to RNA of measles virus were found in tissues affected with systemic lupus erythemotosus. These data open up a new class of virus-cell interaction that may be a result of cooperation between infectious and
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Computer, 2012
The advent of low-cost, large-scale DNA synthesis, coupled with advanced algorithmic tools, opens the door to a host of exciting new biotechnology applications, including vaccines.
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The advent of low-cost, large-scale DNA synthesis, coupled with advanced algorithmic tools, opens the door to a host of exciting new biotechnology applications, including vaccines.
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Fingerprinting of single viral genomes
Analytical Biochemistry, 2005We demonstrate the use of technology developed for optical mapping to acquire DNA fingerprints from single genomes for the purpose of discrimination and identification of bacteria and viruses. Single genome fingerprinting (SGF) provides not only the size but also the order of the restriction fragments, which adds another dimension to the information ...
Matthew M, Ferris +3 more
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Viral carcinogenesis and genomic instability
2006Oncogenes encoded by human tumor viruses play integral roles in the viral conquest of the host cell by subverting crucial and relatively non-redundant regulatory circuits that regulate cellular proliferation, differentiation, apoptosis and life span. Human tumor virus oncoproteins can also disrupt pathways that are necessary for the maintenance of the ...
Karl, Münger +5 more
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The viral genome in transformed cells
Proceedings of the Royal Society of London. Series B. Biological Sciences, 1971Abstract Polyoma and SV 40-transformed cells carry multiple copies of the entire genome in their chromosomes; the viral DNA sequences appear to be covalently integrated into the host cell’s DNA but it is not known whether they are clustered in a reiterated tandem sequence or whether they are distributed singly or in clusters ...
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The Epstein-Barr virus (EBV) genetic map underpins all our understanding of the virus biology and its role in disease. EBV was the first large DNA virus to be fully sequenced and this has been followed by many years of detailed mapping of viral genes and other genetic elements. The genetic map of EBV is based on the reference NC_007605 virus genome but
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2009
Genome replication strategies.- Model of Picornavirus RNA Replication.- Coronavirus Genome Replication.- Flaviviruses.- Hepatitis C Virus Genome Replication.- Brome Mosaic Virus RNA Replication and Transcription.- Retroviruses.- Hepadnaviral Genomic Replication.- Rhabdoviruses.- Orthomyxovirus Genome Transcription and Replication.- Arenaviruses: Genome
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Genome replication strategies.- Model of Picornavirus RNA Replication.- Coronavirus Genome Replication.- Flaviviruses.- Hepatitis C Virus Genome Replication.- Brome Mosaic Virus RNA Replication and Transcription.- Retroviruses.- Hepadnaviral Genomic Replication.- Rhabdoviruses.- Orthomyxovirus Genome Transcription and Replication.- Arenaviruses: Genome
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