Genetic diversity and dynamics of plum pox virus populations in the alternative host American plum. [PDF]
Collum TD, Stone AL, Rogers EE.
europepmc +1 more source
Notch2 Directs aTreg Cell Fate toward Immunoregulation or Inflammatory Pyroptosis
Schematic illustration showing that the Notch2 intracellular domain (NICD2) facilitates pyroptosis resistance in activated Tregs through the RREB1/Foxo1 signaling pathway. In addition, Notch2‐mediated pyroptosis resistance in activated Tregs promotes immunoregulatory capacity, thereby attenuating Th2‐driven inflammatory responses in allergic rhinitis ...
Yue‐Long Qiao +10 more
wiley +1 more source
ViMIC 2.0: an updated database of human disease-related viral mutations, integration sites, and multi-omics data. [PDF]
Huang C +11 more
europepmc +1 more source
Precision Editing of NLRS Improves Effector Recognition for Enhanced Disease Resistance
Precision engineering of plant NLR immune receptors enables rational design of enhanced pathogen resistance through mismatched pairing, domain swapping, and targeted mutagenesis. These approaches achieve multi‐fold expansion in recognition breadth while minimizing autoimmunity risks and fitness penalties.
Vinit Kumar +7 more
wiley +1 more source
Discovering the complete enhancer map of human herpesviruses using a natural language processing model. [PDF]
Roy Chowdhury N +3 more
europepmc +1 more source
Lipid Droplet‐Localized Spindle Apparatus Coiled‐Coil Protein 1 Regulates Lipid Droplet Distribution
SPDL1‐L, a long isoform of SPDL1, is identified as a bona fide lipid droplet‐associated protein that acts as a dynein adaptor to drive perinuclear clustering of lipid droplets. By linking lipid droplets to the microtubule network, SPDL1‐L extends the function of SPDL1 beyond mitosis and contributes to lipid droplet organization and nuclear remodeling ...
Honggang Su +10 more
wiley +1 more source
Comprehensive genome analysis uncovers the diversity of jumbo phages in the pig gut microbiome. [PDF]
Wei C, Chen Z.
europepmc +1 more source
Chikungunya in 2025: Comprehensive Insights into Virology, Diagnostics, Vaccines, and Antiviral Therapies. [PDF]
Zheng Z +8 more
europepmc +1 more source

