Results 271 to 280 of about 2,398,369 (345)

Calicivirus assembly and stability are mediated by the N-terminal domain of the capsid protein with the involvement of the viral genome. [PDF]

PLoS Pathog
Novoa G, Mata CP, Mertens J, Zamora-Ceballos M, Martínez-Romero JM, Fontana J, Carrascosa JL, Bárcena J, Castón JR.   +8 more
europepmc   +1 more source

Morphine Tolerance Gated through EZH2‐Mediated Suppression of Trpc5 in Spinal GABAergic Interneurons in Male Mice

Advanced Science, EarlyView.
Chronic morphine suppresses Trpc5 in spinal GABAergic interneurons via EZH2‐mediated histone modification, reducing Ca2+ influx and GABA release. TRPC5 activation enhances morphine analgesia, while EZH2 inhibition restores efficacy and reverses tolerance.
Li Wan, Mengyao Zhang, Haiyue Guo, Yan Xu, Chenjie Xu, Fan Hu, Yinbing Pan, Xian Wang, Wentao Liu, Chun‐Yi Jiang   +9 more
wiley   +1 more source

Metagenome-assembled complete genome of <i>Bohxovirus</i>, a virulent bacteriophage involved in the prediction of hospital-acquired pneumonia in intubated critically ill patients. [PDF]

Microbiol Resour Announc
Anani H, Destras G, Regue H, Bulteau S, Bressollette-Bodin C, Roquilly A, Josset L.   +6 more
europepmc   +1 more source

Three‐Year Follow‐Up of Neoadjuvant Tislelizumab with Chemotherapy in Locally Advanced Gastric and Gastroesophageal Junction Adenocarcinoma: Revealing Cancer‐Associated Fibroblast Heterogeneity Corresponding to PD‐1 Blockade Efficacy

Advanced Science, EarlyView.
Heterogeneous cancer‐associated fibroblasts orchestrate dual immune microenvironments in LAGC. Abstract The potential for immunotherapy in patients with locally advanced gastric cancer (LAGC) is recently confirmed. To report the 3‐year follow‐up data are aimed from a novel clinical trial. This is a prospective single‐arm phase II trial.
Yao Lin, Xiong Sun, Chengguo Li, Ming Yang, Ke Wu, Ke Liu, Anshu Li, Xiaoming Shuai, Kailin Cai, Zheng Wang, Guobin Wang, Peng Zhang, Jianfeng Shen, Kaixiong Tao, Yuping Yin   +14 more
wiley   +1 more source

Genome sequence of fowlpox virus from a field outbreak in Bangladesh. [PDF]

Microbiol Resour Announc
Mozumder A, Akter S, Mia R, Hasan SMN, Das A, Tasmin J, Mondal ABMHR, Rahman MS, Bhuiyan MIU, Akter S, Saha S, Hossain MG.   +11 more
europepmc   +1 more source

Single‐Cell RNA Sequencing of Thyroid Tissues Reveals Pathogenesis of Graves' Disease

Advanced Science, EarlyView.
Using single‐cell RNA sequencing and TCR profiling, this study constructed an immune cell atlas in thyroid tissue of Graves’ disease (GD), revealing dominant IFN‐γ‐secreting CD4+ T cells, expanded Tph and CD11c+ B cells, and enriched T/NK cells. Notably, GD thyroid follicular cells (TFCs) activated γδ T cells, which recruited cDC1 cells, suggesting a ...
Xiaoyi Zhou, Jia Cong, Rongguang Peng, Dichen Yang, Chenchen Dong, Jing Xie, Jiqi Yan, Jie Kuang, Fubin Li, Leng Siew Yeap, Xiaoyan Xie, Haolong Yin, Rulai Han, Liyun Shen, Yulin Zhou, Guang Ning, Shu Wang, Weiqing Wang, Lei Ye   +18 more
wiley   +1 more source

ZPR1 Is Dispensable for HPV R-Loop Resolution but Regulates Host R-Loop Dynamics. [PDF]

Viruses
Moffitt R, Brooks S, Androphy EJ, DeSmet M.   +3 more
europepmc   +1 more source

The DMHGABA Neurons Play a Crucial Role in The Regulation of Cold‐Induced White Adipose Browning through DMH to LPO Projection

Advanced Science, EarlyView.
GABAergic neurons in the dorsomedial hypothalamus (DMHGABA neurons) act as a key neuronal population controlling cold exposure‐induced white adipose tissue browning. DMHGABA neurons regulate the browning through DMH to the lateral preoptic area (LPO) projection.
Zhijie Su, Yujia Hou, Bingwei Wang, Qian Zhou, Wen Yang, Bingbing Guo, Chenyu Zhang, Miao Zhao, Xiaoning Yang, Jiarui Liu, Xiangyang Xie, Lihua Qin, Weiguang Zhang, Wei L. Shen, Ruimao Zheng   +14 more
wiley   +1 more source

Expression of Viral Genomes

, 2002
openaire   +1 more source

A Marseillevirus isolate from the Brazilian wetlands. [PDF]

Arch Virol
Rodrigues MFDR, Arias NEC, Machado TB, Carvalho JVRP, Júnior JPA, Rosa LH, Alcantara LCJ, Rodrigues RAL, Queiroz VF, Abrahão JS.   +9 more
europepmc   +1 more source