Results 161 to 170 of about 3,155,630 (345)

Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis

Nature Genetics, 2007
J. Rioux, J. Rioux, R. Xavier, K. Taylor, M. Silverberg, P. Goyette, A. Huett, Todd Green, Petric Kuballa, M. Barmada, L. Datta, Y. Shugart, A. Griffiths, S. Targan, A. Ippoliti, E. Bernard, L. Mei, Dan L. Nicolae, M. Regueiro, L. P. Schumm, A. Steinhart, J. Rotter, R. Duerr, Judy H. Cho, M. J. Daly, M. J. Daly, S. Brant   +26 more
semanticscholar   +1 more source

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

Molecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck, Nele De Meulenaere, Thomas Vanpoucke, Joe Ibrahim, Dieter Peeters, Suresh Krishan Yogeswaran, Wen Wen, Paul Van Schil, Jeroen M. H. Hendriks, Jo Raskin, Jan van Meerbeeck, Guy Van Camp, Ken Op de Beeck   +12 more
wiley   +1 more source

Additional file 13 of Genome-wide association study identifies favorable SNP alleles and candidate genes for frost tolerance in pea

, 2020
Sana Beji, Véronique Fontaine, Rosemonde Devaux, Martine Thomas, Sandra Silvia Negro, Nasser Bahrman, Mathieu Siol, Grégoire Aubert, Judith Burstin, Jean‐Louis Hilbert, Bruno Delbreil, Isabelle Lejeune-Hénaut   +11 more
openalex   +1 more source

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease

Nature Genetics, 2009
J. Lambert, S. Heath, G. Even, D. Campion, K. Sleegers, M. Hiltunen, O. Combarros, D. Zélénika, M. Bullido, B. Tavernier, L. Letenneur, K. Bettens, C. Berr, F. Pasquier, N. Fievet, P. Barberger‐Gateau, S. Engelborghs, P. Deyn, I. Mateo, A. Franck, S. Helisalmi, E. Porcellini, O. Hanon, M. Pancorbo, C. Lendon, C. Dufouil, C. Jaillard, T. Léveillard, V. Álvarez, P. Bosco, M. Mancuso, F. Panza, B. Nacmias, P. Bossù, P. Piccardi, G. Annoni, D. Seripa, D. Galimberti, D. Hannequin, F. Licastro, H. Soininen, K. Ritchie, H. Blanché, J. Dartigues, C. Tzourio, I. Gut, C. Broeckhoven, A. Alpérovitch, M. Lathrop, P. Amouyel   +49 more
semanticscholar   +1 more source

Monitoring of circulating tumor DNA allows early detection of disease relapse in patients with operable breast cancer

Molecular Oncology, EarlyView.
Monitoring circulating tumor DNA (ctDNA) in patients with operable breast cancer can reveal disease relapse earlier than radiology in a subset of patients. The failure to detect ctDNA in some patients with recurrent disease suggests that ctDNA could serve as a supplement to other monitoring approaches.
Kristin Løge Aanestad, Marie Austdal, Oddmund Nordgård, Gunnar Mellgren, Satu Oltedal, Marie L. Austbø, Ylva H. Vignes, Thomas Helland, Kristin Jonsdottir, Tone H. Lende, Emilius A. M. Janssen, Bjørnar Gilje, Kjersti Tjensvoll, PBCB study group, Gunnar Mellgren, Tone Hoel Lende, Anette Heie, Kristin Viste, Anita Røyneberg Alvheim, Emiel AM Janssen, Kristin Jonsdottir, Ann Cathrine Kroksveen, Thomas Helland, Einar Gudlaugsson, Oddmund Nordgård, Satu Oltedal, Kristin Løge Aanestad, Jan Terje Kvaløy, Kirsten Lode, Kari Britt Hagen, Marie Austdal, Ylva H. Vignes, Siri Tungland Sola, Nina Egeland Amundsen, Finn Magnus Eliassen, Emeritus Ernst A Lien   +35 more
wiley   +1 more source

Assessing the Causal Impact of Social Isolation on Angina Risk: Evidence from a Two-Sample Mendelian Randomization Study

Journal of Multidisciplinary Healthcare
Shenghua Yan,1,* Feifei Gu,2,* Bei Tian1,2 1Shanghai University of Traditional Chinese Medicine (SHUTCM), Shanghai, 201203, People’s Republic of China; 2Department of Nursing, Shanghai Pudong New Area Zhoupu Hospital (Shanghai Health Medical ...
Yan S, Gu F, Tian B
doaj  

Large-scale genome-wide association study in a Japanese population identifies novel susceptibility loci across different diseases

Nature Genetics, 2020
K. Ishigaki, M. Akiyama, M. Kanai, A. Takahashi, Eiryo Kawakami, Hiroki Sugishita, S. Sakaue, N. Matoba, Siew-Kee Low, Y. Okada, C. Terao, Tiffany Amariuta, S. Gazal, Y. Kochi, M. Horikoshi, Ken Suzuki, K. Ito, S. Koyama, K. Ozaki, S. Niida, Yasushi Sakata, Yasuhiko Sakata, T. Kohno, K. Shiraishi, Y. Momozawa, M. Hirata, K. Matsuda, M. Ikeda, N. Iwata, S. Ikegawa, I. Kou, Toshihiro Tanaka, H. Nakagawa, A. Suzuki, T. Hirota, M. Tamari, K. Chayama, D. Miki, Masaki Mori, S. Nagayama, Y. Daigo, Y. Miki, T. Katagiri, O. Ogawa, W. Obara, Hidemi Ito, Teruhiko Yoshida, I. Imoto, Takashi Takahashi, C. Tanikawa, Takao Suzuki, N. Sinozaki, S. Minami, H. Yamaguchi, S. Asai, Yasuo Takahashi, K. Yamaji, Kazuhisa Takahashi, T. Fujioka, R. Takata, H. Yanai, A. Masumoto, Y. Koretsune, H. Kutsumi, M. Higashiyama, S. Murayama, N. Minegishi, Kichiya Suzuki, K. Tanno, A. Shimizu, T. Yamaji, M. Iwasaki, N. Sawada, H. Uemura, Keitaro Tanaka, M. Naito, Makoto Sasaki, K. Wakai, S. Tsugane, Masayuki Yamamoto, Kazuhiko Yamamoto, Y. Murakami, Yusuke Nakamura, S. Raychaudhuri, J. Inazawa, T. Yamauchi, T. Kadowaki, M. Kubo, Y. Kamatani   +88 more
semanticscholar   +1 more source