Results 161 to 170 of about 3,091,688 (344)
Novel Genetic Locus Implicated for HIV-1 Acquisition with Putative Regulatory Links to HIV Replication and Infectivity: A Genome-Wide Association Study
, 2015 Eric O. Johnson, Dana B. Hancock, Nathan Gaddis, Joshua L. Levy, Grier P. Page, Scott P. Novak, Cristie Glasheen, Nancy L. Saccone, John P. Rice, Michael Moreau, Kimberly F. Doheny, Jane Romm, Andrew I. Brooks, Bradley E. Aouizerat, Laura J. Bierut, Alex H. Kral +15 moreopenalex +2 more sourcesModeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids
Molecular Oncology, EarlyView.This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal +8 morewiley +1 more sourceGenome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis
Nature Genetics, 2007 J. Rioux, J. Rioux, R. Xavier, K. Taylor, M. Silverberg, P. Goyette, A. Huett, Todd Green, Petric Kuballa, M. Barmada, L. Datta, Y. Shugart, A. Griffiths, S. Targan, A. Ippoliti, E. Bernard, L. Mei, Dan L. Nicolae, M. Regueiro, L. P. Schumm, A. Steinhart, J. Rotter, R. Duerr, Judy H. Cho, M. J. Daly, M. J. Daly, S. Brant +26 moresemanticscholar +1 more sourceLarge-scale genome-wide association study in a Japanese population identifies novel susceptibility loci across different diseases
Nature Genetics, 2020 K. Ishigaki, M. Akiyama, M. Kanai, A. Takahashi, Eiryo Kawakami, Hiroki Sugishita, S. Sakaue, N. Matoba, Siew-Kee Low, Y. Okada, C. Terao, Tiffany Amariuta, S. Gazal, Y. Kochi, M. Horikoshi, Ken Suzuki, K. Ito, S. Koyama, K. Ozaki, S. Niida, Y. Sakata, Y. Sakata, T. Kohno, K. Shiraishi, Y. Momozawa, M. Hirata, K. Matsuda, M. Ikeda, N. Iwata, S. Ikegawa, I. Kou, Toshihiro Tanaka, H. Nakagawa, A. Suzuki, T. Hirota, M. Tamari, K. Chayama, D. Miki, Masaki Mori, S. Nagayama, Y. Daigo, Y. Miki, T. Katagiri, O. Ogawa, W. Obara, Hidemi Ito, Teruhiko Yoshida, I. Imoto, Takashi Takahashi, C. Tanikawa, Takao Suzuki, N. Sinozaki, S. Minami, H. Yamaguchi, S. Asai, Yasuo Takahashi, K. Yamaji, Kazuhisa Takahashi, T. Fujioka, R. Takata, H. Yanai, A. Masumoto, Y. Koretsune, H. Kutsumi, M. Higashiyama, S. Murayama, N. Minegishi, Kichiya Suzuki, K. Tanno, A. Shimizu, T. Yamaji, M. Iwasaki, N. Sawada, H. Uemura, Keitaro Tanaka, M. Naito, Makoto Sasaki, K. Wakai, S. Tsugane, Masayuki Yamamoto, Kazuhiko Yamamoto, Y. Murakami, Yusuke Nakamura, S. Raychaudhuri, J. Inazawa, T. Yamauchi, T. Kadowaki, M. Kubo, Y. Kamatani +88 moresemanticscholar +1 more sourceMulti‐omic profiling of squamous cell lung cancer identifies metabolites and related genes associated with squamous cell carcinoma
Molecular Oncology, EarlyView.Using multi‐omic characterization, we aimed to identify key regulators specific to squamous cell lung carcinoma (SqCC). SqCC‐specific differentially expressed genes were integrated with metabolics data. High expression of the creatine transporter SLC6A8, along with elevated creatine levels, appeared to be a distinct metabolic feature of SqCC.Johan Staaf, Daniel Ehinger, Hans Brunnström, Mats Jönsson, Frida Rosengren, Marija Kotevska, Anna Karlsson, Mattias Aine, Christian Frezza, Maria Planck, Elsa Arbajian +10 morewiley +1 more sourceInhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine
Molecular Oncology, EarlyView.The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge +18 morewiley +1 more sourcePatient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity
Molecular Oncology, EarlyView.This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert +16 morewiley +1 more source
