Results 171 to 180 of about 437,516 (199)

Uncovering G Protein‐Coupled Receptors: Novel Targets and Biomarkers for Predicting Glioma Prognosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Low‐grade gliomas (LGG) exhibit significant heterogeneity and recurrence risk. G protein‐coupled receptors (GPCR) contribute to glioma malignant progression, but their prognostic value remains unclear. This work attempts to formulate a GPCR‐based outcome‐predicting model for LGG. Methods Based on TCGA LGG data, the enrichment scores
Jun Yang, Dongxu Zhang, Dongyuan Liu, Da Lin, Hao Wang   +4 more
wiley   +1 more source

A Genome-Wide Association Study Reveals Desmoglein-2 Predominance in Japanese Arrhythmogenic Cardiomyopathy. [PDF]

J Arrhythm
Ishikawa T, Sonehara K, Sonoda K, Hayashi K, Kato K, Nagase S, Kusano K, Aiba T, Horie M, Ohno S, Okada Y, Makita N.   +11 more
europepmc   +1 more source

Prominent Movement Disorders in RNU2‐2‐Related Spliceosomopathy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Pediatric movement disorders often overlap with neurodevelopmental diseases, suggesting shared molecular mechanisms. Variants in small nuclear RNA (snRNA) genes encoding spliceosome components have recently been associated with neurodevelopmental disorders, termed “RNUopathies.” We analyzed genome sequencing data from 14 patients with ...
Magdalena Krygier, Ugo Sorrentino, Matias Wagner, Marta Zawadzka, Anna Lemska, Maria Mazurkiewicz‐Bełdzińska, Michael Zech   +6 more
wiley   +1 more source

A Genome-Wide Association Study of Hidradenitis Suppurativa from the VA's Million Veteran Program.

Dermatology
Wendland ZD, Teerlink CC, Pridgen KM, Lo S, Sayed C, van Straalen KR, Tcheandjieu C, Tsao PS, Chang KM, Li Y, Mohlke KL, Sun Q, Lynch JA, Goldfarb N.   +13 more
europepmc   +1 more source

A pilot genome-wide association study of collagen deposition in collagenous colitis. [PDF]

Gastroenterol Rep (Oxf)
Di Lorenzo B, Zheng T, Rieder F, Colombel JF, Peter I, Kupcinskas J, Ohlsson B, Ferrer Cassado C, Zabana Y, Münch A, Jančiauskas D, Gordon IO, D'Amato M, Roda G.   +13 more
europepmc   +1 more source

Cognitive and Neuroimaging Divergence Between Juvenile and Adult FUS Amyotrophic Lateral Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder characterized by progressive motor neuron degeneration. Fused in sarcoma (FUS)‐associated juvenile ALS (jALS) represents a distinct and aggressive subgroup with rapid deterioration and poor prognosis.
Alexandra V. Jürs, Marcel Naumann, Annaliis Lehto, Hanna Schön, Jens Kurth, Johannes Prudlo, Andreas Hermann, Elisabeth Kasper   +7 more
wiley   +1 more source

Multi-ancestry genome-wide association study in all of Us for primary open-angle glaucoma. [PDF]

Sci Rep
Tavakoli K, Huang BB, Mirmira T, Ma N, Weinreb RN, Baxter SL.   +5 more
europepmc   +1 more source

Human Pegivirus Encephalitis With Brain Detection and Response to Sofosbuvir Ledipasvir

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Human pegivirus (HPgV‐1) has been associated with severe encephalomyelitis in immunocompromised patients. Its neurological spectrum remains poorly defined. We report a slowly progressive encephalitis in a person living with well‐controlled HIV, characterized by white matter abnormalities and inflammatory cerebrospinal fluid (CSF). HPgV RNA was
Antoine Moulignier, Françoise Heran, Francis Lallemand, Pierre Bourdillon   +3 more
wiley   +1 more source

Genome-wide association study reveals the genetic architecture of drought tolerance in maize using yield-based resistance indices and transcriptomic evidence. [PDF]

Plant Genome
Li H, Hu X, Zhang P, Zhao Y, Song Y, Zhang Z, Bu H, Chang J.   +7 more
europepmc   +1 more source

The Multiple Sclerosis Severity Allele rs10191329A and Cognitive Function: A UK Biobank Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT The genome‐wide association study of Multiple Sclerosis severity linked the genetic variant rs10191329A to long‐term disability and implicated brain resilience as a determinant of outcome. We hypothesised that rs10191329A might influence cognition in other neurological diseases and healthy controls.
Ioanna Zimianiti, Sheena Waters, Adil Harroud, Pernilla Stridh, Ruth Dobson, Benjamin M. Jacobs   +5 more
wiley   +1 more source