Results 191 to 200 of about 851,678 (251)

Noncoding Genome‐Wide Association Studies Variant for Obesity: Inroads Into MechanismAn Overview From the AHA's Council on Functional Genomics and Translational Biology

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2016
Connie Wu, Pankaj Arora
doaj   +1 more source

Genome-wide association study of salt tolerance in sorghum during germination. [PDF]

Front Plant Sci
Wang L, Xing Z, Zhou J, Jiang M, Fan Q, Yang G, Li L, Wang Y, Habyarimana E, Wang Y, Hu D, Wang YH.   +11 more
europepmc   +1 more source

RNA Sequencing Resolves Cryptic Pathogenic Variants in Mitochondrial Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Mitochondrial diseases are the most common inherited metabolic disorders, characterized by pronounced clinical and genetic heterogeneity that complicates molecular diagnosis. Although DNA‐based sequencing approaches have become standard in genetic testing, up to half of patients remain without a definitive diagnosis.
Zhimei Liu, Xin Duan, Fatemeh Peymani, Jia Wang, Chengjia Bao, Chaolong Xu, Ying Zou, Zixuan Zhang, Yunxi Zhang, Tongyue Li, Martin Pavlov, Junling Wang, Minhan Song, Tianyu Song, Xiaodi Han, Mingxi Sun, Danmin Shen, Ruoyu Duan, Huafang Jiang, Manting Xu, Holger Prokisch, Fang Fang   +21 more
wiley   +1 more source

Validation of a Genetic Risk Score Combined With Clinical Variables for Predicting Pulmonary Fibrosis in Early Rheumatoid Arthritis

Arthritis Care &Research, EarlyView.
Objective Pulmonary fibrosis (PF) is a severe extra‐articular manifestation of rheumatoid arthritis (RA). This study aimed to externally validate a genetic risk score (GRS) and a combined risk score (CRS) for predicting the risk of RA‐associated PF in an independent cohort of patients with early RA.
Mikael Brink, Austin Wheeler, Bryant R. England, Solbritt Rantapää‐Dahlqvist   +3 more
wiley   +1 more source

Genome-wide association study of molecular markers related to keel length in a specialized strain of yellow feathered broilers. [PDF]

Poult Sci
Tu YJ, Liu YF, Zhang M, Ju XJ, Shan YJ, Ji GG, Shu JT.   +6 more
europepmc   +1 more source

Artificial Intelligence in Systemic Sclerosis: Clinical applications, challenges, and future directions

Arthritis Care &Research, Accepted Article.
Systemic sclerosis (SSc) is a rare autoimmune disease defined by immune dysregulation, vasculopathy, and progressive fibrosis of the skin and internal organs. Despite advances in care, major complications such as interstitial lung disease (ILD) and myocardial involvement remain the leading causes of morbidity and mortality.
Cristiana Sieiro Santos, José Miguel Sequí‐Sabater, Diego Benavent   +2 more
wiley   +1 more source

Identification of candidate genes for heat tolerance in rice by genome-wide association study and transcriptome sequencing. [PDF]

BMC Plant Biol
Zhou Y, Li K, Tang C, Zhu M, Bao Y, Zhang W, Li P, Lv W, Zhang M, Wang C, Zhang D, Shi Y.   +11 more
europepmc   +1 more source

Nanoindentation Criteria for Combinatorial Thin Film Libraries

Advanced Engineering Materials, EarlyView.
Thin‐film material libraries are compositional spreads used for screening composition‐structure‐property relationships. Nanoindentation is often used to characterize mechanical behavior across these systems, however variations in methodology are widespread.
Andre Bohn, Adie Alwen, Andrea M. Hodge
wiley   +1 more source

A genome-wide association study identifies EYA2 as a contributing gene for diabetic retinopathy in type 2 diabetes. [PDF]

Commun Med (Lond)
Cai T, Pan Q, Tao Y, Nangia C, Rajendrakumar AL, Ye Y, Dottorini T, Haque M, Palmer CN, Shao Y, Meng W.   +10 more
europepmc   +1 more source

Lipid Nanoparticles for the Delivery of CRISPR/Cas9 Machinery to Enable Site‐Specific Integration of CFTR and Mutation‐Agnostic Disease Rescue

Advanced Functional Materials, EarlyView.
Lipid nanoparticles (LNPs) are optimized to co‐deliver Cas9‐encoding messenger RNA (mRNA), a single guide RNA (sgRNA) targeting the endogenous cystic fibrosis transmembrane conductance regulator (CFTR) gene, and homologous linear double‐stranded donor DNA (ldsDNA) templates encoding CFTR.
Ruth A. Foley, Paul G. Ayoub, Vrishti Sinha, Colin Juett, Alicia Sanoyca, Emily C. Duggan, Lindsay E. Lathrop, Priyanka Bhatt, Kevin Coote, Beate Illek, Brigitte N. Gomperts, Donald B. Kohn, Steven J. Jonas   +12 more
wiley   +1 more source