Results 231 to 240 of about 3,091,688 (344)

Figure 3 from Region-Based Analyses of Existing Genome-Wide Association Studies Identifies Novel Potential Genetic Susceptibility Regions for Glioma

Karen Alpen, Robert J. MacInnis, Claire M. Vajdic, John Lai, James G. Dowty, Eng‐Siew Koh, Elizabeth Hovey, Rosemary Harrup, Tuong L. Nguyen, Shuai Li, David Joseph, Geza Benke, Pierre‐Antoine Dugué, Melissa C. Southey, Graham G. Giles, Anna K. Nowak, Katharine J. Drummond, Daniel F. Schmidt, John L. Hopper, Miroslaw K. Kapuscinski, Enes Makalic   +20 more
openalex   +1 more source

Genome-wide association study reveals candidate loci for resistance to anthracnose in blueberry. [PDF]

G3 (Bethesda)
Ghimire L, Adunola P, Harmon PF, Azevedo CF, Schultz TJ, Leme B, Enciso-Rodriguez F, Benevenuto J, Ferrão LFV, Munoz PR.   +9 more
europepmc   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Genome-wide association study of lung function decline in adults with and without asthma [PDF]

, 2012
Medea Imboden, Emmanuelle Bouzigon, Ivan Curjuric, Adaikalavan Ramasamy, Ashish Kumar, Dana B. Hancock, Jemma B. Wilk, Judith M. Vonk, Gian Andri Thun, Valérie Siroux, Rachel Nadif, Florent Monier, Juan R. González, Matthias Wjst, Joachim Heinrich, Laura R. Loehr, Nora Franceschini, Kari E. North, Janine Altmüller, Gerard H. Koppelman, Stefano Guerra, Florian Kronenberg, Mark Lathrop, Miriam F. Moffatt, George O'connor, David P. Strachan, Dirkje S. Postma, Stephanie J. London, Christian Schindler, Manolis Kogevinas, F. Kauffmann, Deborah Jarvis, Florence Démenais, Nicole Probst‐Hensch   +33 more
openalex   +1 more source

Genome-Wide Association Study of Varenicline-Aided Smoking Cessation. [PDF]

Nicotine Tob Res
Coley K, Wang Q, Packer R, John C, Abner E, Reis K, Estonian Biobank Research Team, Bedair KF, Srinivasan S, Paciga S, Hyde C, Free RC, Reeve NF, Shepherd DJ, Esko T, Palmer C, Pearson E, Malarstig A, Tobin MD, Batini C.   +19 more
europepmc   +1 more source

New from NPG: Genome-wide association study identifies five new schizophrenia loci

Nature Network Boston, 2011
M. Swami
semanticscholar   +1 more source

A subset of MMR‐proficient colon cancers responds to neoadjuvant immunotherapy

Molecular Oncology, EarlyView.
Tan et al. reveal that a distinct subset of early‐stage pMMR colon cancers can respond to neoadjuvant immunotherapy. In the NICHE‐2 trial, responders (26%) were characterized by chromosomal instability, TP53 mutations, and proliferative cell‐cycle programs, whereas nonresponders showed metabolic and stromal reprogramming with TGF‐β‐driven ...
Eleonora Piumatti, Giovanni Germano, Pietro Paolo Vitiello, Alberto Bardelli   +3 more
wiley   +1 more source

The brief resilience scale: a genome-wide association study in the UK Biobank. [PDF]

BMC Med
Cornelis MC, Caldwell JA, Vu THT, Hennigar SR, Berryman CE, Lieberman HR.   +5 more
europepmc   +1 more source

Protein O‐glycosylation in the Bacteroidota phylum

FEBS Open Bio, EarlyView.
Species of the Bacteroidota phylum exhibit a unique O‐glycosylation system. It modifies noncytoplasmic proteins on a specific amino acid motif with a shared glycan core but a species‐specific outer glycan. A locus of multiple glycosyltransferases responsible for the synthesis of the outer glycan has been identified.
Lonneke Hoffmanns, Dennis Svedberg, André Mateus   +2 more
wiley   +1 more source

Systematic biological prioritization after a genome-wide association study: an application to nicotine dependence [PDF]

, 2008
Scott F. Saccone, Nancy L. Saccone, Gary E. Swan, Pamela A. F. Madden, Alison Goate, John P. Rice, Laura J. Bierut   +6 more
openalex   +1 more source