Results 241 to 250 of about 42,684,660 (287)

Cognitive and Neuroimaging Divergence Between Juvenile and Adult FUS Amyotrophic Lateral Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder characterized by progressive motor neuron degeneration. Fused in sarcoma (FUS)‐associated juvenile ALS (jALS) represents a distinct and aggressive subgroup with rapid deterioration and poor prognosis.
Alexandra V. Jürs, Marcel Naumann, Annaliis Lehto, Hanna Schön, Jens Kurth, Johannes Prudlo, Andreas Hermann, Elisabeth Kasper   +7 more
wiley   +1 more source

Identifying candidate genes for trichome traits in grapevine through a genome-wide association study. [PDF]

BMC Genomics
Yang Z, Zhou Y, Hu L, Zheng Q, Fang C, Zhou S, Yu C, Xu Y, Huang L, Jiang T, Wu Y.   +10 more
europepmc   +1 more source

A Unified Unsupervised Framework for Genome-Wide Association Studies in Heterogeneous Populations [PDF]

Xiong Shen, Zhenshuang Tang, Yong Liao, Zhiyuan Lin, Huajun Zhou, Haohao Zhang, Yangfan Liu, Dong Yin, Yue Wang, Yuan Quan, Zheng Zhuqing, Xiong Xiong, Yuhua Fu, Shuhong Zhao, Xinyun Li, Lilin Yin, Xiaolei Liu   +16 more
openalex   +1 more source

Bi‐ and Mono‐Allelic RFC1 Expansion in a North American Cohort With Idiopathic Axonal Neuropathy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective RFC1 biallelic repeat expansion is increasingly recognized as a cause of chronic idiopathic axonal polyneuropathy (CIAP), but it remains challenging to know who to test. This study aims to determine the prevalence of biallelic and monoallelic RFC1 expansions and their corresponding neuropathy phenotypes in CIAP patients and identify ...
Amro M. Stino, Lavanya Muthukumar, Evan L. Reynolds, Peter Todd, Sinem Ovunc, Sheng Chih Jin, Zitian Tang, Simone Thomas, PNRR Study Group, Ahmet Höke, Brian C. Callaghan, Sarah Berth, Vinay Chaudhry, David Cornblath, Leana Doherty, Lindsey Hayes, Hristelina Ilieva, Thomas Lloyd, Mohammad Khoshnoodi, Brett McCray, Brett Morrison, Bipasha Mukherjee‐Clavin, Lyle Ostrow, Michael Polydefkis, Ricardo Roda, Charlotte Sumner   +25 more
wiley   +1 more source

Genetic Susceptibility to NSAID-Related Gastrointestinal Adverse Events in Korean Patients: An Exploratory Genome-Wide Association Study. [PDF]

J Clin Med
Kim JH, Gil JY, Min KH, Kim HJ, Yang S, Chang SY, Cho BK, Kim HA, Kim W, Kim J, Choi IA, Song N, Han JM, Lee KE.   +13 more
europepmc   +1 more source

Genome-wide association study identifies 10 risk loci for intracerebral hemorrhage in 2,024,474 individuals primarily of European and East Asian ancestries

Guiyou Liu, Shiyang Wu, Ping Zhu, Shan Gao, Fengzhen Liu, Shuyuan Hu, Zhifa Han, Changhong Ren, Yijie He, Mingxin Wang, Qi Yao, Daojing Li, Wenbo Zhao, Sijie Li, Xunming Ji   +14 more
openalex   +1 more source

Blood RNA Biomarker Signatures for Early Diagnosis and Prognosis in Ischemic and Hemorrhagic Stroke: The IBIS‐CT1 Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To evaluate the expression of nine blood RNA biomarkers in a clinical trial based on genes previously identified in an experimental monkey model of stroke for diagnosis feasibility and prognostication. Methods IBIS‐CT1 was a prospective longitudinal study enrolling patients with ischemic stroke (IS) or intracerebral hemorrhage (ICH ...
Salomé Retailleau, Marie Bruguet, Irina Viakhireva‐Dovganyuk, François‐Mathias Merrien, Denis Marechal, Aurore Jourdain, Philippe Goas, Jordan Coris, Julien Asselineau, Maëlys Consigny, Gérald Le Gac, Serge Timsit   +11 more
wiley   +1 more source

Genome-wide association study of periodontitis severity and progression. [PDF]

J Periodontol
Teles F, Chandrasekaran G, Martin L, Shrestha P, Moss K, Patel M, Kallan MJ, Furquim C, Cucchiara AJ, Beck JD, North KE, Glessner J, Divaris K.   +12 more
europepmc   +1 more source

Integrated PANoptosis Profiling Identifies Immunosuppressive Subtypes and a Prognostic Signature With Functional Validation of MLKL in Glioblastoma

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective The prognosis of glioblastoma (GBM) remains highly unfavorable, largely due to high tumor heterogeneity and an immunosuppressive microenvironment. However, the functional role of PANoptosis in this context is poorly understood. Methods Patients were stratified via K‐means clustering. A risk score model was constructed using prognosis‐
Langfei Tian, Minghui Zhao, Yuanbo Hu, Kaiyue Wang, Haiguang Liu, Zetong Bai, Kebin Zheng   +6 more
wiley   +1 more source